Polymer comprising a plurality of phenothiazine groups and methods of making the same

Patent metadata

Field	Value
Publication number	US-10947328-B2
Application number	US-202016859001-A
Country	US
Kind code	B2
Filing date	Apr 27, 2020
Priority date	May 28, 2010
Publication date	Mar 16, 2021
Grant date	Mar 16, 2021

Abstract

A non-leaching mediator may include a polymer having a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone. The plurality of phenothiazine groups may include at least one of a phenothiazine group having the general formula (IV):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and a phenothiazine group having the general formula (V):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.

First claim

What is claimed is:

1. An electrochemical test sensor comprising a working electrode, a counter electrode, an enzyme and a mediator, the mediator including a polymer, the polymer including one or more compounds having the general formula (IX) being reacted with a compound having a plurality of polymerizable groups, wherein the general formula (IX) is as follows:

and salts thereof, where n is about 9.

2. The electrochemical test sensor of claim 1 , wherein the compound having a plurality of polymerizable groups includes epoxide groups.

3. The electrochemical test sensor of claim 1 , wherein the compound having a plurality of polymerizable groups includes isocyanate groups.

4. The electrochemical test sensor of claim 1 , wherein the compound having a plurality of polymerizable groups includes carboxylic acid groups.

5. The electrochemical test sensor of claim 1 , wherein the compound having a plurality of polymerizable groups includes anhydride groups.

6. The electrochemical test sensor of claim 1 , wherein the one or more compounds having the general formula (IX) includes 2-(8-(ω-(bis(ω-hydroxyalkyl)amino)alkyl)-3H-phenothiazin-3-ylideneamino)benzene-1,4-di sulfonic acid.

7. The electrochemical test sensor of claim 1 wherein the enzyme is glucose oxidase.

8. The electrochemical test sensor of claim 1 wherein the enzyme is glucose dehydrogenase.

9. A non-leaching mediator, comprising:
a polymer including one or more compounds having the general formula (IX) being reacted with a compound having a plurality of polymerizable groups, wherein the general formula (IX) is as follows:

and salts thereof, where n is about 9.

10. The mediator of claim 9 , wherein the compound having a plurality of polymerizable groups includes epoxide groups.

11. The mediator of claim 9 , wherein the compound having a plurality of polymerizable groups includes isocyanate groups.

12. The mediator of claim 9 , wherein the compound having a plurality of polymerizable groups includes carboxylic acid groups.

13. The mediator of claim 9 , wherein the compound having a plurality of polymerizable groups includes anhydride groups.

14. The mediator of claim 9 , wherein the one or more compounds having the general formula (IX) includes 2-(8-(ω-(bis(ω-hydroxyalkyl)amino)alkyl)-3H-phenothiazin-3-ylideneamino)benzene-1,4-disulfonic acid.

15. An electrochemical test sensor comprising a working electrode, a counter electrode, an enzyme and a mediator, the mediator including a polymer, the polymer including one or more compounds having the general formula (X) being reacted with a compound having a plurality of polymerizable groups, wherein the general formula (X) is as follows:

and salts thereof, where n is about 9.

16. The electrochemical test sensor of claim 15 , wherein the compound having a plurality of polymerizable groups includes epoxide groups.

17. The electrochemical test sensor of claim 15 , wherein the compound having a plurality of polymerizable groups includes isocyanate groups.

18. The electrochemical test sensor of claim 15 , wherein the compound having a plurality of polymerizable groups includes carboxylic acid groups.

19. The electrochemical test sensor of claim 15 , wherein the compound having a plurality of polymerizable groups includes anhydride groups.

20. The electrochemical test sensor of claim 15 , wherein the one or more compounds having the general formula (IX) includes 2-(2-(ω-(bis(ω-hydroxyalkyl)amino)alkyl)-3H-phenothiazin-3-ylideneamino)benzene-1,4-disulfonic acid.

21. The electrochemical test sensor of claim 15 , wherein the enzyme is glucose oxidase.

22. The electrochemical test sensor of claim 15 , wherein the enzyme is glucose dehydrogenase.

Assignees

• Ascensia Diabetes Care Holdings Ag

Inventors

• Fei Jiangfeng
• Chiang William
• Kerrigan Frank
• Green Stuart
• Robson Craig
• Easterfield Howard

Classifications

• C08G59/4007

  Curing agents not provided for by the groups C08G59/42 - C08G59/66 · CPC title

• C07D279/08

  condensed with carbocyclic rings or ring systems · CPC title

• C12Q1/004

  mediator-assisted · CPC title

• C07D279/20

  with hydrogen atoms directly attached to the ring nitrogen atom · CPC title

• C07D417/14

  containing three or more hetero rings · CPC title