Polymer comprising a plurality of phenothiazine groups and methods of making the same

Patent metadata

Field	Value
Publication number	US-9944725-B2
Application number	US-201615334814-A
Country	US
Kind code	B2
Filing date	Oct 26, 2016
Priority date	May 28, 2010
Publication date	Apr 17, 2018
Grant date	Apr 17, 2018

Abstract

A non-leaching mediator may include a polymer having a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone. The plurality of phenothiazine groups may include at least one of a phenothiazine group having the general formula (IV):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and a phenothiazine group having the general formula (V):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.

First claim

What is claimed is:

1. A polymer, comprising the general formula (VII):

and salts thereof;
where n is about 9,
x and y independently are an integer from 1 to 10,000, and
z is an integer from 0 to 10,000.

2. The polymer of claim 1 , wherein the mole fraction of x and y is from 0.05 to 0.9.

3. A method of making the polymer of claim 1 , comprising:
forming the polymer from
poly(diallylmethylamine), and
a mixture of 2-(8-(ω-haloalkyl)-3H-phenothiazin-3-ylideneamino)benzene-1,4-disulfonic acid and 2-(2-(ω-haloalkyl)-3H-phenothiazin-3-ylideneamino)benzene-1,4-disulfonic acid.

4. The method of claim 3 , further comprising:
forming the mixture of 2-(8-(ω-haloalkyl)-3H-phenothiazin-3-ylideneamino)-benzene-1,4-disulfonic acid and 2-(2-(ω-haloalkyl)-3H-phenothiazin-3-ylideneamino)-benzene-1,4-disulfonic acid.

5. The polymer of claim 2 , wherein the mole fraction of x and y is from 0.07 to 0.7.

6. The polymer of claim 5 , wherein the mole fraction of x and y is from 0.1 to 0.5.

7. The polymer of claim 1 , wherein the sum of x, y and z is from 10 to 10,000.

8. The polymer of claim 7 , wherein the sum of x, y and z is from 20 to 1,000.

9. The polymer of claim 1 , wherein x and y independently are an integer from 1 to 70.

10. The polymer of claim 9 , wherein x and y independently are an integer from 2 to 20.

11. The polymer of claim 10 , wherein x and y independently are an integer from 10 to 30.

12. An electrochemical test sensor comprising a working electrode, a counter electrode and a mediator, the mediator including a polymer comprising the general formula (VII):

and salts thereof;
where n is about 9,
x and y independently are an integer from 1 to 10,000, and
z is an integer from 0 to 10,000.

13. The test sensor of claim 12 , wherein the mole fraction of x and y is from 0.05 to 0.9.

14. The test sensor of claim 13 , wherein the mole fraction of x and y is from 0.07 to 0.7.

15. The test sensor of claim 14 , wherein the mole fraction of x and y is from 0.1 to 0.5.

16. The test sensor of claim 12 , wherein the sum of x, y and z is from 10 to 10,000.

17. The test sensor of claim 16 , wherein the sum of x, y and z is from 20 to 1,000.

18. The test sensor of claim 12 , wherein x and y independently are an integer from 1 to 70.

19. The test sensor of claim 18 , wherein x and y independently are an integer from 2 to 20.

20. The test sensor of claim 19 , wherein x and y independently are an integer from 10 to 30.

21. The test sensor of claim 12 further including glucose oxidase.

22. The test sensor of claim 12 further including glucose dehydrogenase.

Assignees

• Ascensia Diabetes Care Holdings Ag

Inventors

• Fei Jiangfeng
• Chiang William
• Kerrigan Frank
• Green Stuart
• Robson Craig
• Easterfield Howard

Classifications

• C08F8/34 Primary

  Introducing sulfur atoms or sulfur-containing groups · CPC title

• C12Q1/004

  mediator-assisted · CPC title

• G01N27/3272

  Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels (optical biosensors G01N33/52) · CPC title

• C07D279/08

  condensed with carbocyclic rings or ring systems · CPC title

• C08G75/24

  Polysulfonates · CPC title