Polymer comprising a plurality of phenothiazine groups and methods of making the same

Patent metadata

Field	Value
Publication number	US-9505884-B2
Application number	US-201514963908-A
Country	US
Kind code	B2
Filing date	Dec 9, 2015
Priority date	May 28, 2010
Publication date	Nov 29, 2016
Grant date	Nov 29, 2016

Abstract

A non-leaching mediator may include a polymer having a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone. The plurality of phenothiazine groups may include at least one of a phenothiazine group having the general formula (IV):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and a phenothiazine group having the general formula (V):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.

First claim

What is claimed is:

1. A polymer comprising the general formula (VIII):

and salts thereof;
where R′ is an organic group,
m is 0 or 1,
n is about 9, and
x and y independently are an integer from 1 to 10,000.

2. The polymer of claim 1 , wherein the sum of x and y is from 10 to 10,000.

3. The polymer of claim 2 , wherein the sum of x and y is from 20 to 1,000.

4. The polymer of claim 1 , wherein x and y independently are an integer from 1 to 70.

5. The polymer of claim 4 , wherein x and y independently are an integer from 2 to 20.

6. The polymer of claim 4 , wherein x and y independently are an integer from 10 to 30.

7. The polymer of claim 1 , wherein m is 1 and R′ is an aliphatic group.

8. The polymer of claim 7 , wherein R′ is an alkyl group having from 1 to 10 carbons atoms.

9. The polymer of claim 7 , wherein R′ is an aryl group.

10. An electrochemical test sensor including a mediator, the mediator including a polymer comprising the general formula (VIII):

and salts thereof;
where R′ is an organic group,
m is 0 or 1,
n is about 9, and
x and y independently are an integer from 1 to 10,000.

11. The test sensor of claim 10 , wherein the sum of x and y is from 10 to 10,000.

12. The test sensor of claim 11 , wherein the sum of x and y is from 20 to 1,000.

13. The test sensor of claim 10 , wherein x and y independently are an integer from 1 to 70.

14. The test sensor of claim 13 , wherein x and y independently are an integer from 2 to 20.

15. The test sensor of claim 13 , wherein x and y independently are an integer from 10 to 30.

16. The test sensor of claim 10 , wherein m is 1 and R′ is an aliphatic group.

17. The test sensor of claim 16 , wherein R′ is an alky group having from 1 to 10 carbons atoms.

18. The test sensor of claim 16 , wherein R′ is an alkyl group.

19. The test sensor of claim 10 further including glucose oxidase.

20. The test sensor of claim 10 further including glucose dehydrogenase.

Assignees

• Ascensia Diabetes Care Holdings Ag

Inventors

• Fei Jiangfeng
• Chiang William
• Kerrigan Frank
• Green Stuart
• Robson Craig
• Easterfield Howard

Classifications

• C08G59/4007

  Curing agents not provided for by the groups C08G59/42 - C08G59/66 · CPC title

• C12Q1/004

  mediator-assisted · CPC title

• C08G73/024 Primary

  Polyamines containing oxygen in the form of ether bonds in the main chain · CPC title

• C08F8/34 Primary

  Introducing sulfur atoms or sulfur-containing groups · CPC title

• A61K49/0004

  Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions · CPC title