Polymer comprising a plurality of phenothiazine groups and methods of making the same

Patent metadata

Field	Value
Publication number	US-10662264-B2
Application number	US-201815915184-A
Country	US
Kind code	B2
Filing date	Mar 8, 2018
Priority date	May 28, 2010
Publication date	May 26, 2020
Grant date	May 26, 2020

Abstract

A non-leaching mediator may include a polymer having a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone. The plurality of phenothiazine groups may include at least one of a phenothiazine group having the general formula (IV):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and a phenothiazine group having the general formula (V):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.

First claim

What is claimed is:

1. An electrochemical test sensor comprising a working electrode, a counter electrode and a mediator, the mediator including a polymer, the polymer including a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone;
where the plurality of phenothiazine groups includes at least one of a phenothiazine group having the general formula (IV):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and
a phenothiazine group having the general formula (V):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.

2. The electrochemical test sensor of claim 1 , wherein the phenothiazine group is bonded to the polymeric backbone through a carbon-heteroatom bond.

3. The electrochemical test sensor of claim 1 , wherein the phenothiazine group is bonded to the polymeric backbone through a group selected from the group consisting of an ether group, an ester group, a carbonate group, a urea group, a urethane group, an amine group, an amide group, a thioether group, a thiourea group and a sulfonamide group.

4. The electrochemical test sensor of claim 3 , wherein the phenothiazine group is bonded to the polymeric backbone through a group selected from an ether group or an ester group.

5. The electrochemical test sensor of claim 3 , wherein the phenothiazine group is bonded to the polymeric backbone through a carbonate group.

6. The electrochemical test sensor of claim 3 , wherein the phenothiazine group is bonded to the polymeric backbone through a urea group or a urethane group.

7. The electrochemical test sensor of claim 3 , wherein the phenothiazine group is bonded to the polymeric backbone through an amine group or an amide group.

8. The electrochemical test sensor of claim 3 , wherein the phenothiazine group is bonded to the polymeric backbone through a thioether group or a thiourea group.

9. The electrochemical test sensor of claim 3 , wherein the phenothiazine group is bonded to the polymeric backbone through a sulfonamide group.

10. The electrochemical test sensor of claim 1 further including glucose oxidase.

11. The electrochemical test sensor of claim 1 further including glucose dehydrogenase.

12. An electrochemical test sensor comprising a working electrode, a counter electrode, glucose dehydrogenase, and a mediator, the mediator including a polymer, the polymer including a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone;
where the plurality of phenothiazine groups includes at least one of a phenothiazine group having the general formula (IV):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and
a phenothiazine group having the general formula (V):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded,
wherein the phenothiazine group is bonded to the polymeric backbone through a carbon-heteroatom bond.

13. An electrochemical test sensor comprising a working electrode, a counter electrode, glucose oxidase, and a mediator, the mediator including a polymer, the polymer including a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone;
where the plurality of phenothiazine groups includes at least one of a phenothiazine group having the general formula (IV):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and
a phenothiazine group having the general formula (V):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded,
wherein the phenothiazine group is bonded to the polymeric backbone through a carbon-heteroatom bond.

Assignees

• Ascensia Diabetes Care Holdings Ag

Inventors

• Fei Jiangfeng
• Chiang William
• Kerrigan Frank
• Green Stuart
• Robson Craig
• Easterfield Howard

Classifications

• C08F8/34 Primary

  Introducing sulfur atoms or sulfur-containing groups · CPC title

• C07D417/14

  containing three or more hetero rings · CPC title

• C08F8/30

  Introducing nitrogen atoms or nitrogen-containing groups · CPC title

• C07D279/20

  with hydrogen atoms directly attached to the ring nitrogen atom · CPC title

• A61K49/0004

  Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions · CPC title