Biomedical patches with aligned fibers

Patent metadata

Field	Value
Publication number	US-10888409-B2
Application number	US-202016795057-A
Country	US
Kind code	B2
Filing date	Feb 19, 2020
Priority date	Jun 17, 2010
Publication date	Jan 12, 2021
Grant date	Jan 12, 2021

Abstract

A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.

First claim

What is claimed is:

1. A three-dimensional electrospun nanofiber synthetic skin graft for use in repairing tissue for wound care, the three-dimensional electrospun nanofiber synthetic skin graft comprising:
a flexible electrospun fiber network, the flexible electrospun fiber network comprising:
a first set of electrospun fibers comprising a first bioresorbable polymer, wherein the first bioresorbable polymer comprises polyglycolic acid; and
a second set of electrospun fibers comprising a second bioresorbable polymer, wherein the second bioresorbable polymer comprises caprolactone,
wherein the first bioresorbable polymer comprises a different composition from the second bioresorbable polymer;

the flexible electrospun fiber network further comprising a surface, wherein the surface comprises a surface pattern with nanoscale features,
wherein a first portion of the flexible electrospun fiber network of a particular size comprises a higher number of fibers than a second portion of the flexible electrospun fiber network of the particular size, wherein the first portion comprising the higher number of fibers comprises a first spatial variation between fibers that is lower than a second spatial variation between fibers in the second portion comprising a lower number of fibers;
wherein the three-dimensional electrospun nanofiber synthetic skin graft is sufficiently flexible to facilitate application of the three-dimensional electrospun nanofiber synthetic skin graft to uneven surfaces of the tissue,
wherein the three-dimensional electrospun nanofiber synthetic skin graft is sufficiently flexible to enable movement of the three-dimensional electrospun nanofiber synthetic skin graft by the tissue, and
wherein the first set of electrospun fibers and the second set of electrospun fibers are configured to degrade after application to the tissue.

2. The three-dimensional electrospun nanofiber synthetic skin graft of claim 1 , wherein the surface pattern is formed by depositing the first set of electrospun fibers and the second set of electrospun fibers on a mask positioned between a conductive collector and a spinneret.

3. The three-dimensional electrospun nanofiber synthetic skin graft of claim 1 , wherein the surface pattern is formed by depositing the first set of electrospun fibers and the second set of electrospun fibers directly without a mask on one or more electrodes of a conductive collector, wherein at least one of the conductive collector or the one or more electrodes form a pattern.

4. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the pattern of the conductive collector is formed by a plurality of electrodes of the conductive collector.

5. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the pattern of the conductive collector comprises an inverse pattern of the surface pattern of the flexible electrospun fiber network.

6. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the deposited electrospun fiber network comprises one or more fibers having a diameter of 1-1000 nanometers.

7. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein each fiber of the deposited electrospun fiber network comprises a diameter less than 5 microns.

8. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the surface of the flexible electrospun fiber network is adapted to be in contact with the tissue, the first portion and the second portion of the flexible electrospun fiber network forming a part of the surface of the flexible electrospun fiber network.

9. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the surface pattern comprises a topographical pattern.

10. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the surface pattern comprises a repeating pattern.

11. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the surface pattern comprises a plurality of depressions.

12. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the surface pattern comprises a plurality of wells.

13. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the surface pattern comprises a plurality of concave surfaces.

14. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the surface pattern comprises a plurality of convex surfaces.

15. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein at least one of the first set of electrospun fibers or at least one of the second set of electrospun fibers are radially aligned.

16. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the flexible electrospun fiber network comprises a single layer.

17. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the flexible electrospun fiber network comprises multiple layers.

18. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the first set of electrospun fibers and the second set of electrospun fibers are deposited into a single layer.

19. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the first set of electrospun fibers and the second set of electrospun fibers are deposited into different layers.

20. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the first set of electrospun fibers and the second set of electrospun fibers are adapted to degrade within three months.

21. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the first set of electrospun fibers and the second set of electrospun fibers are deposited simultaneously.

22. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the first set of electrospun fibers and the second set of electrospun fibers are deposited in an alternating manner.

23. The three-dimensional electrospun nanofiber synthetic skin graft of claim 3 , wherein the flexible electrospun fiber network further comprises:
one or more fibers comprising a substantially straight portion; and
one or more fibers comprising a substantially curvilinear portion.

24. The three-dimensional electrospun nanofiber synthetic skin graft of claim 23 , wherein the substantially straight portion comprises a length of at least 100 μm.

25. A three-dimensional electrospun nanofiber skin substitute for use in repairing tissue, the three-dimensional electrospun nanofiber skin substitute comprising:
a flexible electrospun fiber network, the flexible electrospun fiber network comprising:
a first set of electrospun fibers comprising a first bioresorbable polymer; and
a second set of electrospun fibers comprising a second bioresorbable polymer,
wherein the first bioresorbable polymer comprises a different composition from the second bioresorbable polymer;

the flexible electrospun fiber network further comprising a surface adapted to be in contact with the tissue, wherein the surface comprises a repeating surface pattern, wherein the repeating surface pattern is formed by depositing the first set of electrospun fibers and the second set of electrospun fibers directly on a conductive collector comprising a pattern, the con

Assignees

• Univ Washington

Inventors

• Macewan Matthew R
• Xie Jingwei
• Ray Zack
• Xia Younan

Classifications

• D04H1/728

  by electro-spinning {(electro-spinning methods and apparatus D01D5/0007)} · CPC title

• D04H1/74

  the fibres being orientated, e.g. in parallel {(anisotropic fleeces)} · CPC title

• D01D5/00 Primary

  Formation of filaments, threads, or the like · CPC title

• A61F13/00

  Bandages or dressings (radioactive dressings {A61N5/1029}); Absorbent pads · CPC title

• A61F2/105

  Skin implants, e.g. artificial skin · CPC title