Use of PEO-PBO block copolymers in ophthalmic compositions

Patent metadata

Field	Value
Publication number	US-10584307-B2
Application number	US-201715398761-A
Country	US
Kind code	B2
Filing date	Jan 5, 2017
Priority date	Dec 11, 2006
Publication date	Mar 10, 2020
Grant date	Mar 10, 2020

Abstract

The use of poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses. Such compounds are also useful for cleaning purposes. The use of the compounds as surfactants in various types of compositions for treating contact lenses therefore represents a preferred embodiment of the present invention.

First claim

We claim:

1. A contact lens product, comprising a package; and a packaging solution for storing a silicone hydrogel contact lens, wherein the packaging solution comprises 0.001 w/v % to about 1 w/v % of at least one poly(oxyethylene)-poly(oxybutylene) block copolymer having a molecular weight in the range of 500 to 100,000 Daltons, and having an osmolality of 200 to 400 milliosmoles/kilogram.

2. The contact lens product according to claim 1 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer is of the formula (EO) m (BO) n , wherein EO is oxyethylene and BO is oxybutylene, and wherein m is an integer having an average value of 10 to 1000 and n is an integer having an average value of 5 to 1000.

3. The contact lens product according to claim 2 , wherein m is greater than n.

4. The contact lens product according to claim 3 , wherein the ratio of m to n is in the range of about 2:1 to about 6:1.

5. The contact lens product according to claim 4 , wherein the ratio of m to n is in the range of about 3:1 to about 6:1.

6. The contact lens product according to claim 5 , wherein the average value of m is 45 and the average value of n is 10.

7. The contact lens product according to claim 1 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer has a molecular weight in the range of 1,000 to 50,000 Daltons.

8. The contact lens product according to claim 7 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer has a molecular weight in the range of 2,000 to 10,000 Daltons.

9. The contact lens product according to claim 1 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer is of the formula

Wherein R is selected from the group consisting of hydrogen, methyl, ethyl, propyl and butyl; m is an integer having an average value of 10 to 1000; and n is an integer having an average value of 5 to 1000.

10. The contact lens product according to claim 9 , wherein R is methyl; m has an average value of 45; and n has an average value of 10.

Assignees

• Alcon Res Ltd
• Alcon Inc

Inventors

• Ketelson Howard Allen
• Mcqueen Nathaniel D

Classifications

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P27/02

  Ophthalmic agents · CPC title

• A61F2/1691

  Packages or dispensers for intraocular lenses (for contact lenses A45C11/005) · CPC title

• C11D3/3707

  Polyethers, e.g. polyalkyleneoxides · CPC title

• C11D1/008

  Polymeric surface-active agents · CPC title