Bioeffective krill oil compositions

Patent metadata

Field	Value
Publication number	US-10543237-B2
Application number	US-201816023146-A
Country	US
Kind code	B2
Filing date	Jun 29, 2018
Priority date	Mar 28, 2007
Publication date	Jan 28, 2020
Grant date	Jan 28, 2020

Abstract

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO 2 or CO 2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO 2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

First claim

The invention claimed is:

1. A method of increasing muscle mass in a subject comprising administering to the subject an effective amount of a krill oil composition under conditions such that muscle mass is increased, the krill oil composition comprising from 3% to 10% ether phospholipids w/w of said krill oil; from about 27% to 50% non-ether phospholipids w/w of said krill oil so that the amount of total phospholipids in the composition is from about 30% to 60% w/w of said krill oil; from about 20% to 50% triglycerides w/w of said krill oil, and astaxanthin esters in amount of greater than about 100 mg/kg of said krill oil.

2. The method of claim 1 , wherein the subject is a human subject.

3. The method of claim 1 , wherein protein catabolism is decreased in the subject.

4. The method of claim 1 , wherein the effective amount of krill oil is a daily dose of from 0.2 to 10 grams/day.

5. The method of claim 1 , wherein the effective amount of krill oil is provided in a soft gel capsule.

6. A method of increasing muscle mass in a human subject comprising administering to the human subject from 0.2 to 10 grams/day of a krill oil composition under conditions such that muscle mass is increased, the krill oil composition comprising from 3% to 10% ether phospholipids w/w of said krill oil; from about 27% to 50% non-ether phospholipids w/w of said krill oil so that the amount of total phospholipids in the composition is from about 30% to 60% w/w of said krill oil; from about 20% to 50% triglycerides w/w of said krill oil, and astaxanthin esters in amount of greater than about 100 mg/kg of said krill oil.

Assignees

• Aker Biomarine Antarctic As

Inventors

• Bruheim Inge
• Tilseth Snorre
• Mancinelli Daniele

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K9/4858

  Organic compounds · CPC title

• A61K31/122

  having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin · CPC title

• A23L33/115

  Fatty acids or derivatives thereof; Fats or oils · CPC title