Bioeffective krill oil compositions

Patent metadata

Field	Value
Publication number	US-9320765-B2
Application number	US-201314020155-A
Country	US
Kind code	B2
Filing date	Sep 6, 2013
Priority date	Mar 28, 2007
Publication date	Apr 26, 2016
Grant date	Apr 26, 2016

Abstract

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO 2 or CO 2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO 2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

First claim

The invention claimed is:

1. A krill oil composition comprising Euphausia superba krill oil suitable for oral administration, said krill oil comprising greater than about 3% ether phospholipids w/w of said krill oil; from about 27% to 50% non-ether phospholipids w/w of said krill oil so that the amount of total phospholipids in the composition is from about 30% to 60% w/w of said krill oil; from about 20% to 50% triglycerides w/w of said krill oil, and astaxanthin esters in amount of greater than about 100 mg/kg of said krill oil.

2. The krill oil composition of claim 1 , wherein said krill oil contains greater than about 200 mg/kg astaxanthin esters.

3. The krill oil composition of claim 1 , wherein said krill oil contains greater than about 300 mg/kg astaxanthin esters.

4. The krill oil composition of claim 1 , wherein said krill oil contains greater than about 400 mg/kg astaxanthin esters.

5. The krill oil composition of claim 1 , wherein said krill oil comprises from about 20% to 35% omega-3 fatty acids as a percentage of total fatty acids in said composition.

6. The krill oil composition of claim 5 , wherein from about 70% to 95% of said omega-3 fatty acids are attached to said phospholipids.

7. The krill oil composition of claim 1 , wherein said krill oil is contained in a soft gel capsule.

8. The krill oil composition of claim 1 , wherein said krill oil composition comprises a plant phytonutrient.

9. The krill oil composition of claim 1 , wherein said krill oil comprises greater than about 4% w/w ether phospholipids.

10. The krill oil composition of claim 9 , wherein said krill oil comprises greater than about 200 mg/kg astaxanthin esters.

11. The krill oil composition of claim 9 , wherein said krill oil comprises greater than about 300 mg/kg astaxanthin esters.

12. The krill oil composition of claim 10 , wherein said krill oil comprises from about 20% to 35% omega-3 fatty acids as a percentage of total fatty acids in said composition.

13. The krill oil composition of claim 12 , wherein from about 70% to 95% of said omega-3 fatty acids are attached to said phospholipids.

14. The krill oil composition of claim 10 , wherein said krill oil comprises greater than about 400 mg/kg astaxanthin esters.

15. The krill oil composition of claim 14 , wherein said krill oil comprises from about 20% to 35% omega-3 fatty acids as a percentage of total fatty acids in said composition.

16. The krill oil composition of claim 15 , wherein from about 70% to 95% of said omega-3 fatty acids are attached to said phospholipids.

17. The krill oil composition of claim 11 , wherein said krill oil composition comprises a plant phytonutrient.

18. The krill oil composition of claim 1 , wherein said krill oil comprises greater than about 5% w/w ether phospholipids.

19. The krill oil composition of claim 18 , wherein said krill oil comprises greater than about 200 mg/kg astaxanthin esters.

20. The krill oil composition of claim 18 , wherein said krill oil comprises greater than about 300 mg/kg astaxanthin esters.

21. The krill oil composition of claim 19 , wherein said krill oil comprises from about 20% to 35% omega-3 fatty acids as a percentage of total fatty acids in said composition.

22. The krill oil composition of claim 21 , wherein from about 70% to 95% of said omega-3 fatty acids are attached to said phospholipids.

23. The krill oil composition of claim 15 , wherein said krill oil comprises greater than about 400 mg/kg astaxanthin esters.

24. The krill oil composition of claim 19 , wherein said krill oil composition comprises a plant phytonutrient.

25. Encapsulated krill oil comprising:
a capsule containing a safe and effective amount of Euphausia superba krill oil, said krill oil comprising greater than about 3% ether phospholipids w/w of said krill oil; from about 27% to 50% non-ether phospholipids w/w of said krill oil so that the amount of total phospholipids in the composition is from about 30% to 60% w/w of said krill oil; from about 20% to 50% triglycerides w/w of said krill oil, and astaxanthin esters in amount of greater than about 100 mg/kg of said krill oil.

26. The encapsulated krill oil of claim 25 , wherein said krill oil in said capsules contains greater than about 200 mg/kg astaxanthin esters.

27. The encapsulated krill oil of claim 25 , wherein said krill oil in said capsules contains greater than about 300 mg/kg astaxanthin esters.

28. The encapsulated krill oil of claim 25 , wherein said krill oil in said capsules contains greater than about 400 mg/kg astaxanthin esters.

29. The encapsulated krill oil of claim 25 , wherein said krill oil in said capsules comprises from about 20% to 35% omega-3 fatty acids as a percentage of total fatty acids in said composition.

30. The encapsulated krill oil of claim 29 , wherein from about 70% to 95% of said omega-3 fatty acids are attached to said phospholipids.

31. The encapsulated krill oil of claim 25 , wherein said capsule is a soft gel capsule.

32. The encapsulated krill oil of claim 25 , wherein said capsule further contains a plant phytonutrient.

33. The encapsulated krill oil of claim 25 , wherein said krill oil in said capsules comprises greater than about 4% w/w ether phospholipids.

34. The encapsulated krill oil of claim 33 , wherein said krill oil in said capsules comprises greater than about 200 mg/kg astaxanthin esters.

35. The encapsulated krill oil of claim 33 , wherein said krill oil in said capsules comprises greater than about 300 mg/kg astaxanthin esters.

36. The encapsulated krill oil of claim 34 , wherein said krill oil in said capsules comprises from about 20% to 35% omega-3 fatty acids as a percentage of total fatty acids in said composition.

37. The encapsulated krill oil of claim 36 , wherein from about 70% to 95% of said omega-3 fatty acids are attached to said phospholipids.

38. The encapsulated krill oil of claim 34 , wherein said krill oil in said capsules comprises greater than about 400 mg/kg astaxanthin esters.

39. The encapsulated krill oil of claim 38 , wherein said krill oil in said capsules comprises from about 20% to 35% omega-3 fatty acids as a percentage of total fatty acids in said composition.

40. The encapsulated krill oil of claim 39 , wherein from about 70% to 95% of said omega-3 fatty acids are attached to said phospholipids.

41. The encapsulated krill oil of claim 34 , wherein said capsule further contains a plant phytonutrient.

42. The encapsulated krill oil of claim 25 , wherein said krill oil in said capsules comprises greater than about 5% w/w ether phospholipids.

43. The encapsulated krill oil of claim 42 , wherein said krill oil in said capsules comprises greater than about 200 mg/kg astaxanthin esters.

44. The encapsulated krill oil of claim 42 , wherein said krill oil in said capsules comprises greater than about 300 mg/kg astaxanthin esters.

45. The encapsulated krill oil of claim 43 , wherein said krill oil in said capsules comprises from about 20% to 35% omega-3 fatty acids as a percentage of total fatty acids in said composition

Assignees

• Aker Biomarine Antarctic As

Inventors

• Bruheim Inge
• Tilseth Snorre
• Mancinelli Daniele

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A61K9/4858

  Organic compounds · CPC title

• A61K31/122

  having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin · CPC title

• A61K9/4825

  Proteins, e.g. gelatin (gelatin capsule shells with substantial amounts of other macromolecular substances A61K9/4816) · CPC title

• A61K31/683

  Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols · CPC title