Peroxide contact lens care solution

Patent metadata

Field	Value
Publication number	US-10130733-B2
Application number	US-201313835237-A
Country	US
Kind code	B2
Filing date	Mar 15, 2013
Priority date	Jun 18, 2010
Publication date	Nov 20, 2018
Grant date	Nov 20, 2018

Abstract

The invention is directed to a method of cleaning and disinfecting a contact lens. The method includes instructing a consumer to disinfect their contact lens comprising the following steps: remove a contact from an eye and position the lens in a lens assembly that includes a cap member; add a disinfection solution to the lens case such that the lens is submerged in the solution upon closure of the lens case with the cap member. The disinfection solution will comprise 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and a P-metal modulating compound. The presence of the P-metal modulating compound in the disinfection solution decreases the neutralization rate of the hydrogen peroxide. The disinfection system exhibits a pseudo first-order, half-life of hydrogen peroxide from 12 minutes to 30 minutes over an initial sixty minutes of neutralization following exposure of the disinfection solution to a catalyst comprising a P-metal. This reduction in rate of peroxide neutralization can provide a more effective solution for killing certain microorganisms and fungi.

First claim

We claim:

1. A method of cleaning and disinfecting a contact lens, the method comprising instructing a consumer to disinfect their contact lens comprising the following steps:
remove a contact lens from an eye and position the lens in a lens assembly that includes a cap member;
attach a catalytic element comprising a P-metal to the lens assembly; and
add a disinfection solution to a lens case, and insert the lens assembly with the attached catalytic element into the lens case such that the lens and catalytic element are submerged in the solution upon closure of the lens case with the cap member, said disinfection solution comprising 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and a P-metal modulating compound, wherein the molar ratio of the hydrogen peroxide to the P-metal modulating compound is from 3:1 to 100:1, and wherein the solution exhibits a pseudo first-order, half-life of hydrogen peroxide from 12 minutes to 30 minutes over an initial sixty minutes of neutralization following exposure of the disinfection solution to a catalyst comprising a P-metal.

2. The method of claim 1 wherein upon closure of the lens case with the cap member the disinfection solution exhibits a pseudo first-order, half-life of hydrogen peroxide over the initial sixty minutes of from 14 minutes to 22 minutes, and the concentration of hydrogen peroxide after six hours of neutralization is less than 150 ppm.

3. A method of cleaning and disinfecting a contact lens, the method comprising instructing a consumer to disinfect their contact lens comprising the following steps:
remove a contact lens from an eye and position the lens in a lens assembly that includes a cap member;
attach a catalytic element comprising a P-metal to the lens assembly; and
add a disinfection solution to a lens case, and insert the lens assembly with the attached catalytic element into the lens case such that the lens and catalytic element are submerged in the solution upon closure of the lens case with the cap member, said disinfection solution comprising 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and a P-metal modulating compound, wherein the molar ratio of the hydrogen peroxide to the P-metal modulating compound is from 3:1 to 100:1, and wherein upon closure of the lens case the solution exhibits a pseudo first-order, half-life of hydrogen peroxide over an initial sixty minutes of neutralization following exposure of the disinfection solution to a catalyst comprising a P-metal that is 1.25 times to 2 times greater with the P-metal modulating compound in the solution than in the absence of the P-metal modulating compound.

4. A method of cleaning and disinfecting a contact lens, the method comprising instructing a consumer to disinfect their contact lens comprising the following steps:
remove a contact lens from an eye and position the lens in a lens assembly that includes a cap member;
attach a catalytic element comprising a P-metal to the lens assembly; and
add a disinfection solution to a lens case, and insert the lens assembly with the attached catalytic element into the lens case such that the lens and catalytic element are submerged in the solution upon closure of the lens case with the cap member, said disinfection solution comprising 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and a P-metal modulating compound, wherein the molar ratio of the hydrogen peroxide to the P-metal modulating compound is from 3:1 to 100:1, and wherein the disinfection solution exhibits a hydrogen peroxide neutralization profile that is more effective against Candida albicans or Serratia marcescens by 0.5 log-kill or greater after an initial four hours of neutralization following exposure of the disinfection solution to a catalyst comprising a P-metal than an equivalent contact lens disinfection solution but without the P-metal modulating compound, said disinfection solution having an osmolality value of from 150 mOsmol/kg to 500 mOsmol/kg following neutralization of the hydrogen peroxide.

5. The method of claim 1 wherein the P-metal modulating compound is of general formula I

wherein R 1 is C 1 -C 6 alkyl, —(CH 2 )CH( + NH 3 )(CO 2 − ) and n is 1 or 2, or NHR 3 ; and R 3 is H or R 2 , and R 2 is H, OH or C 1 -C 6 alkyl.

6. The method of claim 1 wherein the P-metal modulating compound comprises one or two nitrogen atoms and one to six carbon atoms.

7. The method of claim 3 wherein the P-metal modulating compound is of general formula I

wherein R 1 is C 1 -C 6 alkyl, —(CH 2 )CH( + NH 3 )(CO 2 − ) and n is 1 or 2, or NHR 3 ; and R 3 is H or R 2 , and R 2 is H, OH or C 1 -C 6 alkyl.

8. The method of claim 3 wherein the P-metal modulating compound comprises one or two nitrogen atoms and one to six carbon atoms.

9. The method of claim 4 wherein the P-metal modulating compound is of general formula I

wherein R 1 is C 1 -C 6 alkyl, —(CH 2 ) n CH( + NH 3 )(CO 2 − ) and n is 1 or 2, or NHR 3 ; and R 3 is H or R 2 , and R 2 is H, OH or C 1 -C 6 alkyl.

10. The method of claim 4 wherein the P-metal modulating compound comprises one or two nitrogen atoms and one to six carbon atoms.

11. The method of claim 1 wherein the P-metal modulating compound is an amino acid or a compound derived from an amino acid.

12. The method of claim 11 wherein the amino acid is present in the solution from 0.05 wt. % to 0.4 wt. %.

13. The method of claim 1 wherein the disinfection solution further comprises a polyoxyethylene/polyoxypropylene condensation polymer surfactant.

14. The method of claim 3 wherein the disinfection solution further comprises a polyoxyethylene/polyoxypropylene condensation polymer surfactant.

15. The method of claim 4 wherein the disinfection solution further comprises a polyoxyethylene/polyoxypropylene condensation polymer surfactant.

16. The method of claim 5 , wherein R 1 is NHR 3 and R 2 and R 3 are H, and the molar concentration of the P-metal modulating compound is less than the molar concentration of the hydrogen peroxide in the disinfection solution.

17. The method of claim 7 , wherein R 1 is NHR 3 and R 2 and R 3 are H, and the molar concentration of the P-metal modulating compound is less than the molar concentration of the hydrogen peroxide in the disinfection solution.

18. The method of claim 9 , wherein R 1 is NHR 3 and R 2 and R 3 are H, and the molar concentration of the P-metal modulating compound is less than the molar concentration of the hydrogen peroxide in the disinfection solution.

19. The method of claim 1 , wherein the catalytic element attached to the lens assembly comprises a platinum disk.

20. The method of claim 3 , wherein the catalytic element attached to the lens assembly comprises a platinum disk.

21. The method of claim 4 , wherein the catalytic element attached to the lens assembly comprises a platinum disk.

22. The method of claim 1 , wherein the solution is under conditions at or about ambient temperature while the lens is submerged therein.

23. The method of claim 3 , wherein the solution is under

Assignees

• Bausch & Lomb

Inventors

• Millard Kimberly Anne
• Xia Erning
• Groemminger Suzanne F
• Kilbury Jenilee

Classifications

• C11D3/3947

  Liquid compositions · CPC title

• C11D7/3218

  Alkanolamines or alkanolimines · CPC title

• C11D7/3272

  Urea, guanidine or derivatives thereof · CPC title

• C11D3/0078 Primary

  Compositions for cleaning contact lenses, spectacles or lenses · CPC title

• C11D7/3245

  Aminoacids · CPC title