Bioeffective krill oil compositions

Patent metadata

Field	Value
Publication number	US-10010567-B2
Application number	US-201715589605-A
Country	US
Kind code	B2
Filing date	May 8, 2017
Priority date	Mar 28, 2007
Publication date	Jul 3, 2018
Grant date	Jul 3, 2018

Abstract

This disclosure discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO 2 or CO 2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO 2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

First claim

The invention claimed is:

1. Encapsulated krill oil comprising a capsule containing Euphausia superba krill oil suitable for oral administration, said krill oil comprising greater than 30% phosphatidylcholine w/w of said krill oil, less than 3% free fatty acids w/w of said krill oil and astaxanthin esters.

2. Encapsulated krill oil of claim 1 , wherein said krill oil comprises greater than 40% phosphatidylcholine w/w of said krill oil.

3. Encapsulated krill oil of claim 1 , wherein said krill oil comprises greater than 45% phosphatidylcholine w/w of said krill oil.

4. Encapsulated krill oil of claim 1 , wherein said capsule contains a phytonutrient derived from a source other than krill.

5. Encapsulated krill oil of claim 1 , wherein said krill oil further comprises from 20% to 50% w/w triglycerides.

6. Encapsulated krill oil of claim 5 , wherein said krill oil further comprises at least 20% omega-3 fatty acids as a percentage of total fatty acids in said composition.

7. Encapsulated krill oil of claim 1 , wherein said capsule is a soft gel capsule.

8. Encapsulated krill oil of claim 1 , wherein said krill oil comprises less than about 3% lysophosphatidylcholine w/w of said krill oil.

9. Encapsulated krill oil of claim 1 , wherein said krill oil comprises less than about 2% lysophosphatidylcholine w/w of said krill oil.

10. Encapsulated krill oil of claim 1 , wherein said astaxanthin esters are present in the krill oil at in an amount of at least 100 mg/kg.

11. Encapsulated krill oil of claim 1 , wherein said astaxanthin esters are present in the krill oil at in an amount of at least 200 mg/kg.

12. Encapsulated krill oil of claim 1 , wherein said krill oil comprises less than about 0.45% arachidonic acid w/w of said krill oil, wherein w/w is the weight percent of arachidonic acid as a percent of total fatty acids.

13. Encapsulated krill oil of claim 1 , wherein said krill oil comprises less than about 0.5 g/100 g total cholesterol.

14. Encapsulated krill oil of claim 1 , wherein said krill oil comprises at least 36% w/w omega-3 fatty acids, wherein w/w is the weight percent of omega-3 fatty acids as a percent of total fatty acids.

15. Encapsulated krill oil comprising a soft gel capsule containing Euphausia superba krill oil suitable for oral administration, said krill oil comprising greater than 30% phosphatidylcholine w/w of said krill oil, less than 3% free fatty acids w/w of said krill oil, less than about 3% lysophosphatidylcholine w/w of said krill oil and at least 100 mg/kg astaxanthin esters.

16. Encapsulated krill oil of claim 15 , wherein said krill oil comprises greater than 40% phosphatidylcholine w/w of said krill oil.

17. Encapsulated krill oil of claim 15 , wherein said astaxanthin esters are present in the krill oil at in an amount of at least 200 mg/kg.

18. Encapsulated krill oil of claim 15 , wherein said krill oil comprises less than about 0.45% w/w arachidonic acid, wherein w/w is the weight percent of arachidonic acid as a percent of total fatty acids.

19. Encapsulated krill oil of claim 15 , wherein said krill oil comprises less than about 0.5 g/100 g total cholesterol.

20. Encapsulated krill oil of claim 15 , wherein said krill oil comprises at least 36% w/w omega-3 fatty acids, wherein w/w is the weight percent of omega-3 fatty acids as a percent of total fatty acids.

Assignees

• Aker Biomarine Antarctic As

Inventors

• Bruheim Inge
• Tilseth Snorre
• Mancinelli Daniele

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A61K31/23

  of acids having a carboxyl group bound to a chain of seven or more carbon atoms · CPC title

• A61K9/4858

  Organic compounds · CPC title

• A61K31/575

  substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol · CPC title

• A61K31/20

  having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids · CPC title