Automated fluid handling system

Patent metadata

Field	Value
Publication number	US-RE47124-E
Application number	US-201015008155-A
Country	US
Kind code	E1
Filing date	Jun 4, 2010
Priority date	Jun 9, 2009
Publication date	Nov 13, 2018
Grant date	Nov 13, 2018

Abstract

Automated fluid handling system comprising a housing ( 20 ) and two or more fluid handling units ( 26 ) arranged as interchangeable modular components with an external fluidics section ( 30 ) and an internal non fluidics section ( 32 ), and wherein the housing ( 20 ) comprises a liquid handling panel ( 22 ) with two or more of component positions for receiving said interchangeable modular components ( 26 ) such that the external fluidics section ( 30 ) is separated from the non fluidics section ( 32 ) by the liquid handling panel ( 22 ).

First claim

What is claimed is:

1. Automated fluid handling system comprising a housing and two or more interchangeable fluid handling units the housing comprising a liquid handling panel including two or more component positions for receiving said interchangeable units, wherein said units are arranged as interchangeable modular components, and include:
a fluidics section; a non fluidics section comprising electronics or electrical components or control means; and a panel member arranged to separate the fluidics section from the non fluidics section and for attachment of the modular component to a component position of the liquid handling panel,
and wherein the two or more component positions of the liquid handling panel are arranged for attachment of the panel members such that said respective fluidics sections are external to the housing and said respective non fluidics sections are internal to the housing.

2. The fluid handling system of claim 1 , wherein the interchangeable modular components are sealed against the liquid handling panel by a sealing member.

3. The fluid handling system of claim 1 , comprising a master control unit wherein the interchangeable modular components are connected to the master control unit by a system bus providing electrical communication to each interchangeable modular component.

4. The fluid handling system of claim 1 , wherein all interchangeable modular components are of same size.

5. The fluid handling system of claim 1 , wherein the interchangeable modular components are of two or more sizes.

6. The fluid handling system of claim 1 , comprising at least one fluid pump, at least one sensor unit and two or more fluid control valves of at least two different configurations, wherein at least the fluid control valves comprise said interchangeable modular components.

7. The fluid handling system of claim 3 , wherein the master control unit comprises a system climate controller for controlling the climate in the housing and the interchangeable modular components.

8. The fluid handling system of claim 1 , wherein the housing comprises an internal climate panel arranged spaced from the liquid handling panel within the housing, said internal climate panel defining on one side an air inlet compartment and defining on an opposing side an air outlet compartment in the housing, the climate panel being provided with complementary component positions for receiving the internal non fluidics section of the interchangeable modular components, and wherein the non-fluidics section of at least one interchangeable modular component is provided with one or more air inlet openings located in the air inlet compartment and one or more air outlet openings located in the air outlet compartment when the interchangeable modular component is arranged in position in the component position.

9. The fluid handling system of claim 8 , further comprising a system cooling unit providing a flow of air from the air inlet compartment to the air outlet compartment, through said at least one interchangeable modular component.

10. The fluid handling system of claim 8 , wherein said at least one interchangeable modular component is provided with a local cooling unit providing a flow of air from the air inlet compartment to the air outlet compartment.

11. The fluid handling system of claim 1 , wherein the system is a liquid chromatography system arranged to provide a controlled fluid flow through a chromatography column.

12. The fluid handling system of claim 1 , wherein the system is a liquid filtration system.

13. The fluid handling system of claim 1 , wherein the system is a chemical synthesis system.

14. The fluid handling system according to claim 1 wherein the system further comprises at least one expansion housing module for accommodating additional interchangeable modular components.

15. The fluid handling system according to claim 14 , further including means for automatic detection of said module to allow automatic configuration of the system by a master control unit.

16. A liquid chromatography system arranged to provide a controlled fluid flow through a chromatography column, the system comprising a housing and two or more interchangeable fluid handling units, the housing comprising a liquid handling panel including two or more component positions for receiving said interchangeable units, wherein said units are arranged as interchangeable modular components, and include:
a fluidics section;
a non fluidics section in turn comprising electronics or electrical components or control means; and
a panel member arranged to separate the fluidics section from the non fluidics section and for attachment of the modular component to a component position of the liquid handling panel,

and wherein the liquid handling panel of the housing and the panel members are arranged such that the fluidics sections are external to the housing and respective non fluidics sections are internal to the housing.

17. The liquid chromatography system according to claim 16 , wherein the interchangeable modular components include at least one two of: an injection valve; a column valve with integrated pressure sensors; a conductivity monitor; a UV monitor; a quaternary valve; an inlet valve with integrated air sensor; a system pump; a pump pressure monitor; an inlet valve with integrated air sensor; a rising valve; a mixer; a filter; a sample inlet valve; a flow restrictor; a pH valve; an outlet valve; and or a dummy component.

18. The liquid chromatography system according to claim 17 , wherein said modular components are interconnected fluidically on the external side of the panel.

19. The liquid chromatography system of claim 16, wherein the interchangeable modular components are sealed against the liquid handling panel by a sealing member.

20. The liquid chromatography system of claim 16, comprising a master control unit wherein the interchangeable modular components are connected to the master control unit by a system bus providing electrical communication to each interchangeable modular component, and wherein each of the interchangeable modular components includes a dedicated CPU unit allowing each of the interchangeable modular components to independently perform operations in response to instructions over the bus.

21. The liquid chromatography system of claim 16, wherein all interchangeable modular components are of same size.

22. The liquid chromatography system of claim 16, wherein the interchangeable modular components are of two or more sizes.

23. The liquid chromatography system of claim 16, comprising at least one fluid pump, at least one sensor unit and two or more fluid control valves of at least two different configurations, wherein at least the fluid control valves are arranged as interchangeable modular components.

24. The liquid chromatography system of claim 20, comprising at least one fluid pump, at least one sensor unit and two or more fluid control valves of at least two different configurations, wherein at least the fluid control valves are arranged as interchangeable modular components.

25. The liquid chromatography system of claim 16 wherein the system further comprises at least one expansion housing module for accommodating additional interchangeable modular components at the liquid handling panel.

26. The liquid chromatography system of claim 16, wherein the housing includes at least four component positions.

Assignees

• Ge Healthcare Bio Sciences Ab
• Ge Healthcare Bio Science Ab

Inventors

• Blomberg Johan
• Lundkvist Mats

Classifications

• G01N30/88 Primary

  Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 · CPC title

• G01N2030/8804

  automated systems · CPC title

• Y10T137/87885

  Sectional block structure · CPC title

• B01D17/12

  Auxiliary equipment particularly adapted for use with liquid-separating apparatus, e.g. control circuits · CPC title

• G01N30/38

  Flow patterns · CPC title