Automated fluid handling system

Patent metadata

Field	Value
Publication number	US-9404902-B2
Application number	US-201414463039-A
Country	US
Kind code	B2
Filing date	Aug 19, 2014
Priority date	Jun 9, 2009
Publication date	Aug 2, 2016
Grant date	Aug 2, 2016

Abstract

Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel.

First claim

The invention claimed is:

1. An automated liquid chromatography system comprising:
a housing;
a master control unit connected to a system bus; and
two or more fluid handling units arranged as interchangeable modular components comprising with (i) an external fluidics section, (ii) an internal fluidics section including a bus connector for directly connecting the modular component with the system bus, and (iii) a panel member arranged to separate the fluidics section from the non-fluidics section, and
wherein the housing comprises a liquid handling panel with two or more component positions adapted to receive said interchangeable modular components such that, when inserted, the fluidics section is external to the housing and the non fluidics section is internal to the housing,
wherein each component position includes a complementary connector for connecting the bus connector of the interchangeable modular component inserted therein to said system bus and wherein each modular component includes a dedicated CPU unit allowing the modular component to independently perform operations in response to instructions over the system bus,
wherein the master control unit is arranged to automatically identify interchangeable modular components,
wherein said housing is adapted to accommodate at least one pump, at least one sensor unit and at least two fluid control valves of different configurations, of which at least two of the pump, the sensor unit, and the fluid control valves are modular components, and
wherein the system is capable of performing automated liquid chromatography.

2. The chromatography system of claim 1 , wherein the interchangeable modular components are sealed against the liquid handling panel by a sealing member.

3. The chromatography system of claim 1 , wherein all interchangeable modular components are of same size.

4. The chromatography system of claim 1 , wherein the interchangeable modular components are of two or more sizes.

5. The chromatography system of claim 1 , wherein the at least two fluid control valves are arranged as interchangeable modular components.

6. The chromatography system of claim 1 , wherein said interchangeable modular components further comprises a local cooling unit.

7. The chromatography system of claim 1 , wherein the housing includes at least four component positions.

8. The chromatography system of claim 1 , wherein the system includes at least one dummy component arranged in a component position not occupied by any one of said interchangeable modular components.

9. The chromatography system of claim 1 , wherein the system includes at least two fluid pumps.

10. The chromatography system of claim 1 , wherein the component positions are arranged in a two dimensional array.

11. The chromatography system of claim 7 , wherein the at least four component positions are arranged in a two dimensional array.

12. The chromatography system of claim 1 , wherein the system further comprises a pH electrode that is external to the housing.

13. The chromatography system of claim 1 , wherein the fluidics section of each interchangeable modular component comprises one or fluid connectors for connecting the fluid handling unit to a liquid chromatography fluid path and wherein all fluid connectors are on a wet side of the panel member.

14. The chromatography system of claim 13 , wherein the liquid chromatography fluid path is reconfigurable by moving the interchangeable modular components freely between the component positions.

15. The chromatography system of claim 1 , wherein the system further comprises at least one expansion housing module arranged to be attached to the housing and for accommodating additional interchangeable modular components at the liquid handling panel.

16. The chromatography system of claim 15 , wherein the master control unit is arranged to automatically detect said at least one expansion housing module and to perform automatic configuration of the system.

17. The chromatography system of claim 1 comprising
two double piston pumps,
one injection valve for injecting sample onto a column connecting a flow path of the liquid chromatography system
a UV monitor, and
a mixer.

18. The chromatography system of claim 17 wherein the pumps, valve, monitor, and mixer are interchangeable modular components.

19. The chromatography system of claim 17 , wherein the pumps are configured to provide a flow rate between 0.001 ml/min and 25 ml/min.

20. The chromatography system of claim 17 , wherein the system further comprises a column valve comprising pressure sensors integrated into inlet and outlet ports of the column valve for measuring the actual pressure over the connected column.

21. The chromatography system of claim 17 , which further comprises a sample inlet valve.

22. The chromatography system of claim 17 , which further comprises a conductivity monitor.

23. The chromatography system of claim 17 , which further comprises at least one expansion housing module arranged to be attached to the housing and for accommodating additional interchangeable modular components at the liquid handling panel.

24. The chromatography system according to claim 23 , wherein the master control unit is arranged to automatically detect said at least one expansion housing module and to perform automatic configuration of the system.

25. The chromatography system according to claim 1 , wherein the at least two fluid control valves include an injection valve, a column valve with integrated pressure sensors, a quaternary valve, an inlet valve, a sample inlet valve, a pH valve, or an outlet valve.

26. The chromatography system according to claim 5 , wherein the at least two fluid control valves include an injection valve, a column valve with integrated pressure sensors, a quaternary valve, an inlet valve, a sample inlet valve, a pH valve, or an outlet valve.

27. The chromatography system according to claim 11 , wherein the system includes at least two fluid pumps.

28. The chromatography system according to claim 17 , wherein the at least two fluid control valves include an injection valve, a column valve with integrated pressure sensors, a quaternary valve, an inlet valve, a sample inlet valve, a pH valve, or an outlet valve.

29. The chromatograph system according to claim 12 , wherein the pH electrode is connected to a pH valve formed as an interchangeable modular component.

30. The chromatography system according to claim 29 , wherein the pH valve includes an integrated flow cell for in-line monitoring of pH levels.

31. The chromatography system of claim 1 , wherein the system includes
two double piston pumps,
one injection valve for injecting a sample onto a column connected to a flow path of the liquid chromatography system,
a UV monitor,
a mixer,
a pH-valve with an integrated flow cell for in-line monitoring of pH levels, and
a quaternary valve for automatic buffer preparation and formation of quaternary gradients.

32. The chromatography system of claim 31 , wherein the pumps, injection valve, monitor, mixer, pH valve, and quaternary valve are interchangeable modular components.

33. A automated liquid chromatography system comprising
a housing;
a master control unit connected to a system bus; and
two or more fluid handl

Assignees

• Ge Healthcare Bio Sciences Ab

Inventors

• Blomberg Johan
• Lundkvist Mats

Classifications

• B01D2201/54

  Computerised or programmable systems · CPC title

• G01N2030/8881

  Modular construction, specially adapted therefor · CPC title

• B01D15/08

  Selective adsorption, e.g. chromatography · CPC title

• Y10T137/87885

  Sectional block structure · CPC title

• Y10T137/85986

  Pumped fluid control · CPC title