Automated fluid handling system

Patent metadata

Field	Value
Publication number	US-9709589-B2
Application number	US-201615165876-A
Country	US
Kind code	B2
Filing date	May 26, 2016
Priority date	Jun 9, 2009
Publication date	Jul 18, 2017
Grant date	Jul 18, 2017

Abstract

Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel.

First claim

The invention claimed is:

1. An automated liquid chromatography system comprising a housing unit and at least four modular fluid handling units,
wherein the housing unit
comprises on one external side of the housing unit a plurality of receiving positions, each receiving position adapted to receive the modular fluid handling units therein such that a fluid handling section thereof is on the external side of the housing unit, the receiving positions being arranged in a two dimensional array,

wherein each modular fluid handling unit
is configured for insertion into the receiving positions of the housing unit,
is readily interchangeable amongst similarly sized and shaped receiving positions of the housing unit, such that positioning of the modular fluid handling unit with respect to other modular fluid handling units permits a fluid flow path to be readily modified, wherein the fluid flow path is formed by fluidic connections between the modular fluid handling units, and
includes a CPU for independently performing fluid control operations in response to instructions over a system BUS.

2. The automatic liquid chromatography system of claim 1 , wherein the modular fluid handling units are each connected to the system BUS.

3. The automatic liquid chromatography system of claim 1 , wherein the modular fluid handling units include a double piston pump, a sample pump, an inlet valve for selecting inlet fluid to a respective pump, an injection valve for injecting a sample onto a column connected to the flow fluid path of the liquid chromatography system, a column valve for connecting one of a plurality of columns to the flow fluid path, a UV-monitor, a mixer, a pH valve with an integrated flow cell for in-line monitoring of pH levels, a quaternary valve for automatic buffer preparation for formation of quaternary gradients, or any combination thereof.

4. The automatic liquid chromatography system of claim 1 , further comprising an expansion housing unit that includes a plurality of receiving positions, each receiving position being adapted to receive the modular fluid handling units.

5. The automatic liquid chromatography system of claim 1 , wherein the CPU automatically configures the modular fluid handling unit within the liquid chromatography system upon insertion into the receiving positions of the housing unit.

6. An automated liquid chromatography system comprising a housing unit and at least four freely arrangeable modular fluid handling units that control fluid flow through at least one chromatography column when fluidically interconnected to form a fluid flow path, wherein:
the housing unit is adapted to receive the modular fluid handling units;
the modular fluid handling units are adapted to fit into receiving positions of the housing unit, and each modular fluid handling unit includes a CPU for performing fluid control operations independently irrespective of the location within the housing unit; and
a master control unit arranged to communicate through a system BUS to each fluid handling unit.

7. The automatic liquid chromatography system of claim 6 , wherein said housing unit is adapted to accommodate at least one pump, at least one sensor unit and at least two fluid control valves of different configurations, of which at least two of the pump, the sensor unit, and the fluid control valves are freely arrangeable modular fluid handling units.

8. The automatic liquid chromatography system of claim 1 , wherein the housing unit is adapted to accommodate at least one pump, at least one sensor unit and at least two fluid control valves of different configurations, of which at least two of the pump, the sensor unit, and the fluid control valves are arranged as modular fluid handling units.

9. The automatic liquid chromatography system of claim 8 , wherein the at least two fluid control valves include an injection valve, a column valve with integrated pressure sensors, a quaternary valve, an inlet valve, a sample inlet valve, a pH valve, and an outlet valve.

10. The automatic liquid chromatography system of claim 1 , wherein the fluid handling section of the modular fluid handling unit is sealed from an internal side of the housing unit when received in a receiving position of the housing unit.

11. The automatic liquid chromatography system of claim 1 , wherein the modular fluid handling units are of the same size.

12. The automatic liquid chromatography system of claim 1 , wherein the modular fluid handling units are of two or more sizes.

13. The automatic liquid chromatography system of claim 1 , wherein the automatic liquid chromatography system further comprises a pH electrode that is external to the housing unit, and
wherein the pH electrode is connected to a pH valve arranged as a modular fluid handling unit.

14. The automatic liquid chromatography system of claim 13 , wherein the pH valve includes an integrated flow cell for in-line monitoring of pH levels.

15. The automatic liquid chromatography system of claim 1 , wherein the modular fluid handling units include two double piston pumps, one injection valve for injecting sample onto a column connecting a flow path of the liquid chromatography system, a UV monitor, and a mixer.

16. The automatic liquid chromatography system of claim of claim 15 , wherein the automatic liquid chromatography system further includes a column valve comprising pressure sensors integrated into inlet an outlet ports of the column valve for measuring the actual pressure over the connected column.

17. The automatic liquid chromatography system of claim of claim 15 , wherein the automatic liquid chromatography system further includes a sample inlet valve.

18. The automatic liquid chromatography system of claim of claim 15 , wherein the automatic liquid chromatography system further includes a conductivity monitor.

19. The automatic liquid chromatography system of claim 7 , wherein the at least two fluid control valves include an injection valve, a column valve with integrated pressure sensors, a quaternary valve, an inlet valve, a sample inlet valve, a pH valve, and an outlet valve.

20. The automatic liquid chromatography system of claim 6 , wherein the modular fluid handling unit includes one or more fluid connectors for connecting the modular fluid handling unit to the fluid path and wherein all fluid connectors are on an external side of the housing unit when the modular fluid handling unit is fitted into a receiving position of the housing unit.

21. The automatic liquid chromatography system of claim 20 , wherein the fluid handling section of the modular fluid handling unit is sealed from an internal side of the housing unit when fitted in a receiving position of the housing unit.

22. The automatic liquid chromatography system of claim 6 , wherein the modular fluid handling units are of the same size.

23. The automatic liquid chromatography system of claim 6 , wherein the modular fluid handling units are of two or more sizes.

24. The automatic liquid chromatography system of claim 6 , wherein the automatic liquid chromatography system further comprises a pH electrode that is external to the housing unit, and
wherein the pH electrode is connected to a pH valve arranged as a modular fluid handling unit.

25. The automatic liquid chromatography system of claim 24 , wherein the pH valve includes an integrated flow cell for in-line monitoring of pH levels.

26. The automa

Assignees

• Ge Healthcare Bio Sciences Ab

Inventors

• Blomberg Johan
• Lundkvist Mats

Classifications

• Y10T137/85986

  Pumped fluid control · CPC title

• Y10T137/6851

  With casing, support, protector or static constructional installations · CPC title

• Y10T137/6525

  Air heated or cooled [fan, fins, or channels] · CPC title

• G01N2030/8804

  automated systems · CPC title

• G01N30/24

  Automatic injection systems · CPC title