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Phosphate binder formulation for simple dosing
US9974805B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9974805-B2 |
| Application number | US-201615144138-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 2, 2016 |
| Priority date | Oct 13, 2010 |
| Publication date | May 22, 2018 |
| Grant date | May 22, 2018 |
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- Title
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- Abstract
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Abstract
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The invention relates to a pharmaceutical composition in the form of pourable granules or a chewable tablet containing at least one phosphate binding substance and at least one effervescent agent. The composition may be taken orally without adding water.
First claim
Opening claim text (preview).
The invention claimed is: 1. A pharmaceutical composition for treating a renally insufficient patient having hyperphosphatemia comprising untableted granules having a phosphate binding core with a taste-masking coating thereon, a) the coating containing at least one effervescent agent comprising magnesium carbonate and a solid organic edible acid or acidic salt thereof, wherein the solid organic edible acid is selected from the group consisting of citric acid, tartaric acid, malic acid, adipic acid, succinic acid, fumaric acid, ascorbic acid, and maleic acid, and b) the core containing, at a weight ratio of 1:1 to 4:1, calcium acetate and magnesium carbonate as phosphate binding substance, wherein calcium acetate and magnesium carbonate combined constitute 15-80% of the weight of the composition, wherein the granules have an average particle size of 100-3500 μm. 2. The composition of claim 1 , wherein the coating is a spray coating. 3. The composition of claim 1 , wherein the coating is a melt coating. 4. The composition of claim 1 , wherein the coating is a spray coating of suspensions and/or solutions. 5. The composition of claim 1 , wherein the granules further contain at least one sugar alcohol. 6. The composition of claim 1 , wherein the effervescent agent constitutes 3-60% of the weight of the composition. 7. The composition of claim 1 in the form of a unit dose containing 0.5-5 g of the granules. 8. The composition of claim 1 , in the form of a stickpack containing 0.5-4 g of the granules.
Assignees
Inventors
Classifications
Polycarboxylic acids · CPC title
Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals · CPC title
of the kidneys · CPC title
Organic compounds, e.g. phospholipids, fats · CPC title
Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60) · CPC title
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Frequently asked questions
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- What does patent US9974805B2 cover?
- The invention relates to a pharmaceutical composition in the form of pourable granules or a chewable tablet containing at least one phosphate binding substance and at least one effervescent agent. The composition may be taken orally without adding water.
- Who is the assignee on this patent?
- Fresenius Medical Care Deutschland Gmbh
- What technology area does this patent fall under?
- Primary CPC classification A61K33/10. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 22 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).