Multipart fluid system and a system for regional citrate anticoagulation in an extracorporeal blood circuit

Patent metadata

Field	Value
Publication number	US-9486570-B2
Application number	US-201414553417-A
Country	US
Kind code	B2
Filing date	Nov 25, 2014
Priority date	Mar 31, 2009
Publication date	Nov 8, 2016
Grant date	Nov 8, 2016

Abstract

A method of treating blood withdrawn from patient including: simultaneously withdrawing blood and infusing withdrawn blood from and to the patient by flowing the withdrawn blood through an extracorporeal dialysis circuit including a dialyzer having a semi-permeable dialysis membrane and a dialysate side adjacent the membrane; feeding a dialysate containing 1 to 5 mM total calcium and 2 to 8 mM citrate to the dialysate side of the dialyzer, and introducing an anticoagulation fluid including at least 8 mM citrate into the arterial blood line.

First claim

The invention claimed is:

1. A multipart fluid system for treating extracorporeal blood comprising:
an extracorporeal blood passage including an inlet configured to receive blood withdrawn from a patient and an outlet configured to discharge treated blood to be infused into the patient;
a pump configured to be coupled to the extracorporeal blood passage to simultaneously withdraw blood from the patient, pass withdrawn blood through the blood passage and infuse treated blood into the patient;
a first fluid source configured to be in fluid communication with the extracorporeal blood passage, wherein the first fluid source contains an anticoagulation fluid including at least 8 mM citrate, and
a second fluid source configured to be in fluid communication with the extracorporeal blood passage, wherein the second fluid source contains a blood treatment fluid comprising 2-8mM citrate and 1 to 5 mM total calcium.

2. The multipart fluid system according to claim 1 wherein the anticoagulation fluid further comprises 1.5-4 mM total calcium.

3. The multipart fluid system according to claim 1 wherein the anticoagulation fluid comprises 8-50 mM citrate.

4. The multipart fluid system according to claim 1 wherein the anticoagulation fluid comprises 10-50 mM citrate.

5. The multipart fluid system according to claim 1 wherein the anticoagulation fluid comprises 17-50 mM citrate.

6. The multipart fluid system according to claim 1 wherein the anticoagulation fluid comprises 2-3 mM total calcium.

7. The multipart fluid system according to claim 1 wherein the anticoagulation fluid comprises 2.2-2.6 mM total calcium.

8. The multipart fluid system according to claim 1 wherein the anticoagulation fluid further comprises 0-1.5 mM magnesium, 0-5.0 mM potassium, 0-11 mM glucose, 130-150 mM sodium and 0 140 mM chloride.

9. The multipart fluid system according to claim 1 wherein the blood treatment fluid comprises 2.0-7.0 mM citrate and 1.8-2.4 mM total calcium.

10. The multipart fluid system according to claim 1 wherein the blood treatment fluid comprises 3.0-5.0 mM citrate and 1.8-2.4 mM total calcium.

11. The multipart fluid system according to claim 1 wherein the blood treatment fluid further comprises 0-1.5 mM magnesium, 0-5.0 mM potassium, 0-11 mM glucose, 130 -150 mM sodium and 80-150 mM chloride, and 0-2.8 mM phosphate.

12. The multipart fluid system according to claim 1 wherein the blood treatment fluid further comprises a physiological buffer.

13. The multipart fluid system according to claim 12 wherein the physiological buffer includes bicarbonate.

14. The multipart fluid system according to claim 13 wherein the blood treatment fluid comprises no more than 3.1 mM bicarbonate.

15. The multipart fluid system according to claim 9 wherein the blood treatment fluid further comprises 0.1-3.0 mM gluconic acid.

16. The multipart fluid system according to claim 1 wherein the blood treatment fluid includes the infusion fluid which is to be used as post infusion fluid.

17. The multipart fluid system according to claim 1 which is devoid of a post infusion fluid comprising at least 6 mM total calcium.

18. The multipart fluid system according to claim 1 wherein the anticoagulation fluid comprises 2.4 mM total calcium.

Assignees

• Gambro Lundia Ab

Inventors

• Sternby Jan

Classifications

• A61P7/08

  Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock (artificial tears A61P27/04) · CPC title

• A61K31/194 Primary

  having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid · CPC title

• A61K31/7004

  Monosaccharides having only carbon, hydrogen and oxygen atoms · CPC title

• A61K33/20

  Elemental chlorine; Inorganic compounds releasing chlorine · CPC title

• A61K33/10

  Carbonates; Bicarbonates · CPC title