Phosphate binder formulation for simple dosing

Patent metadata

Field	Value
Publication number	US-2016243160-A1
Application number	US-201615144138-A
Country	US
Kind code	A1
Filing date	May 2, 2016
Priority date	Oct 13, 2010
Publication date	Aug 25, 2016
Grant date	—

Abstract

The invention relates to a pharmaceutical composition in the form of pourable granules or a chewable tablet containing at least one phosphate binding substance and at least one effervescent agent. The composition may be taken orally without adding water.

First claim

1 - 19 . (canceled)

20 : A pharmaceutical composition for treating a renally insufficient patient having hyperphosphatemia comprising untableted granules containing at least one effervescent agent and, at a weight ratio of 1:1 to 4:1, calcium acetate and magnesium carbonate.

21 : The composition of claim 20 wherein the granules have an average particle size of 100-3500 μm with a taste-masking coating thereon, wherein the taste masking coating comprises at least one phosphate binding substance and at least one effervescent agent containing a carbonate and a solid organic edible acid or the acidic salt thereof.

22 : The composition of claim 21 , wherein the carbonate is an alkali or alkaline earth carbonate or an alkali or alkaline earth bicarbonate.

23 : The composition of claim 21 , wherein the phosphate-binding substance is a calcium salt, a magnesium salt, an ion exchanger polymer, a lanthanum compound, or an iron compound.

24 : The composition of claim 21 , wherein the phosphate binding substance is calcium acetate.

25 : The composition of claim 21 , wherein the coating is a spray coating.

26 : The composition of claim 21 , wherein the coating is a melt coating.

27 : The composition of claim 21 , wherein the coating is a spray coating of suspensions and/or solutions.

28 : The composition of claim 21 , wherein the carbonate is magnesium carbonate.

29 : The composition of claim 21 , wherein the granules further contain at least one sugar alcohol.

30 : The composition of claim 21 , wherein the phosphate-binding substance constitutes 15-80% of the weight of the composition.

31 : The composition of claim 21 , wherein the effervescent agent constitutes 3-60% of the weight of the composition.

32 : The composition of claim 21 in the form of a unit dose containing 0.5-5 g of the granules.

33 : The composition of claim 21 , in the form of a stickpack containing 0.5-4 g of the granules.

Assignees

• Fresenius Medical Care Deutschland Gmbh

Inventors

• Strothmann Kai
• Schulze Friedrich
• Bartholomaeus Johannes
• Fries-Schaffner Eva
• Oppermann Astrid

Classifications

• A61K9/0056

  Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals · CPC title

• A61K33/06

  Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay} · CPC title

• A61K9/0007

  Effervescent (A61K9/0065 takes precedence) · CPC title

• A61K31/225

  Polycarboxylic acids · CPC title

• A61K9/1635

  obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates · CPC title