Genetically encoded calcium indicators
US-9518980-B2 · Dec 13, 2016 · US
Genetically encoded calcium indicators and methods of use
US9945844B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9945844-B2 |
| Application number | US-201615342295-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 3, 2016 |
| Priority date | Oct 10, 2012 |
| Publication date | Apr 17, 2018 |
| Grant date | Apr 17, 2018 |
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Abstract
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Genetically encoded calcium indicator (GECI) polypeptides and the nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides in methods of screening for agonists or antagonists of G-protein coupled receptor (GPCR) or ion channels and methods of monitoring neural activity also are provided.
First claim
Opening claim text (preview).
What is claimed is: 1. A nucleic acid molecule encoding a genetically encoded calcium indicator (GECI) polypeptide, wherein the GECI polypeptide comprises an amino acid sequence having at least 99% sequence identity to the sequence as set forth in SEQ ID NO: 10. 2. The nucleic acid molecule of claim 1 , wherein the GECI comprises SEQ ID NO:10. 3. The nucleic acid molecule of claim 1 , wherein the nucleic acid molecule comprises the sequence as set forth in SEQ ID NO:9. 4. A vector comprising the nucleic acid molecule of claim 1 . 5. An isolated cell comprising the vector of claim 4 . 6. An isolated cell comprising the nucleic acid molecule of claim 1 . 7. A GECI polypeptide, wherein the polypeptide comprises an amino acid sequence having at least 99% sequence identity to the sequence shown in SEQ ID NO:10. 8. The polypeptide of claim 7 , wherein the polypeptide comprises the amino acid sequence shown in SEQ ID NO:10. 9. A cell comprising a polypeptide of claim 7 .
Assignees
Inventors
Classifications
- G01N33/5041Primary
involving analysis of members of signalling pathways · CPC title
Calcium binding proteins, e.g. calmodulin · CPC title
Calcium binding proteins, e.g. calmodulin · CPC title
involving cells · CPC title
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof · CPC title
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- What does patent US9945844B2 cover?
- Genetically encoded calcium indicator (GECI) polypeptides and the nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides in methods of screening for agonists or antagonists of G-protein coupled receptor (GPCR) or ion channels and methods of monitoring neural activity also are provided.
- Who is the assignee on this patent?
- Hughes Howard Med Inst
- What technology area does this patent fall under?
- Primary CPC classification G01N33/5041. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Apr 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).