Use of polypeptides with calcium indicator activity for identifying the activity of insecticidal proteins
US-2024426834-A1 · Dec 26, 2024 · US
Genetically encoded calcium indicators
US9518980B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9518980-B2 |
| Application number | US-201313801120-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 13, 2013 |
| Priority date | Oct 10, 2012 |
| Publication date | Dec 13, 2016 |
| Grant date | Dec 13, 2016 |
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Abstract
Official abstract text for this publication.
Genetically encoded calcium indicator (GECI) polypeptides and the nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides in methods of screening for agonists or antagonists of G-protein coupled receptor (GPCR) or ion channels and methods of monitoring neural activity also are provided.
First claim
Opening claim text (preview).
What is claimed is: 1. An isolated nucleic acid molecule encoding a genetically encoded calcium indicator (GECI) polypeptide, wherein the GECI polypeptide comprises an amino acid sequence having at least 99% sequence identity to the sequence as set forth in SEQ ID NO: 6. 2. The isolated nucleic acid molecule of claim 1 , wherein the GECI comprises SEQ ID NO:6. 3. A vector comprising the isolated nucleic acid molecule of claim 1 . 4. An isolated cell comprising the vector of claim 3 . 5. An isolated cell comprising the nucleic acid molecule of claim 1 .
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Classifications
Calcium binding proteins, e.g. calmodulin · CPC title
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof · CPC title
involving cells · CPC title
containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP] · CPC title
Calcium binding proteins, e.g. calmodulin · CPC title
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- What does patent US9518980B2 cover?
- Genetically encoded calcium indicator (GECI) polypeptides and the nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides in methods of screening for agonists or antagonists of G-protein coupled receptor (GPCR) or ion channels and methods of monitoring neural activity also are provided.
- Who is the assignee on this patent?
- Hughes Howard Med Inst
- What technology area does this patent fall under?
- Primary CPC classification G01N33/5041. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Dec 13 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).