Vaccines and diagnostics for the ehrlichioses
US-10131705-B2 · Nov 20, 2018 · US
US9850295B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9850295-B2 |
| Application number | US-201715440958-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 23, 2017 |
| Priority date | Jan 10, 2008 |
| Publication date | Dec 26, 2017 |
| Grant date | Dec 26, 2017 |
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The present invention concerns VLPT immunoreactive compositions for E. chaffeensis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. chaffeensis VLPT are disclosed.
Opening claim text (preview).
What is claimed is: 1. An isolated antibody that recognizes and immunologically binds to a polypeptide consisting of SEQ ID NO: 3; SEQ ID NO: 4; SEQ ID NO: 8; SEQ ID NO: 9; SEQ ID NO: 10; or SEQ ID NO: 11, or an amino acid sequence that is at least 95% identical thereto, wherein the antibody is either bound to a solid support or a detectable label. 2. The antibody of claim 1 , wherein the antibody is a monoclonal antibody, is comprised in polyclonal antisera, or is an antibody fragment. 3. The antibody of claim 2 , wherein the antibody is a monoclonal antibody. 4. The antibody of claim 2 , wherein the antibody is comprised in polyclonal antisera. 5. The antibody of claim 1 , wherein the polypeptide consists of SEQ ID NO:3. 6. The antibody of claim 1 , wherein the polypeptide consists of SEQ ID NO:4. 7. The antibody of claim 1 , wherein the polypeptide consists of SEQ ID NO:8. 8. The antibody of claim 1 , wherein the polypeptide consists of SEQ ID NO:9. 9. The antibody of claim 1 , wherein the polypeptide consists of SEQ ID NO:10. 10. The antibody of claim 1 , wherein the polypeptide consists of SEQ ID NO:11. 11. The antibody of claim 1 , wherein the detectable label is a radioactive label, a fluorescent label, a chemiluminescent label, an enzyme label, or a paramagnetic label.
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