Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent

Patent metadata

Field	Value
Publication number	US-9849152-B2
Application number	US-201615186113-A
Country	US
Kind code	B2
Filing date	Jun 17, 2016
Priority date	Apr 30, 2002
Publication date	Dec 26, 2017
Grant date	Dec 26, 2017

Abstract

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.

First claim

What is claimed is:

1. A composition, comprising a mixture of an enriched Scutellaria extract comprising Free-B-ring flavonoids containing baicalin, and an enriched Uncaria extract comprising flavans containing catechin and/or epicatechin,
wherein the Scutellaria extract is from Scutellaria baicalensis or Scutellaria orthocalyx,
wherein the Uncaria extract is from Uncaria gambir, Uncaria tomentosa , or Uncaria africana , and
wherein the ratio of Free-B-ring flavonoids to flavans in the composition ranges from 70:30 to 90:10.

2. The composition of claim 1 , wherein the ratio of Free-B-ring flavonoids to flavans in the composition ranges from 80:20 to 85:15.

3. The composition of claim 1 , wherein at least 80% of the total weight of the composition comprises Free-B-ring flavonoids and flavans.

4. The composition of claim 1 , wherein the major active components of the composition are the Free-B-ring flavonoids and the flavans.

5. The composition of claim 1 , wherein the major active ingredients of the composition are baicalin, catechin, and epicatechin.

6. The composition of claim 1 , wherein the Free-B-ring flavonoids and the flavans are extracted from a plant part selected from the group consisting of stems, stem barks, trunks, trunk barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers, and leaves.

7. The composition of claim 1 , wherein each extract is enriched from a hot water extract.

8. The composition of claim 1 , wherein each extract is enriched from an alcohol extract.

9. The composition of claim 1 , wherein the Scutellaria extract is from Scutellaria baicalensis , and the Uncaria extract is from Uncaria gambir.

10. The composition of claim 9 , wherein each extract is enriched from a hot water extract.

11. The composition of claim 10 , wherein the ratio of Free-B-ring flavonoids to flavans in the composition ranges from 80:20 to 85:15.

12. The composition of claim 11 , further comprising an adjuvant, excipient or carrier.

13. The composition of claim 12 , wherein the adjuvant, excipient or carrier is selected from one or more of calcium-based salts, silica, boron, histidine, glucosamine sulfate, chondroitin sulfate, copper gluconate, cellulose, dextrose, saline, water, oil, vitamin D, and shark and bovine cartilage.

14. The composition of claim 9 , wherein each extract is enriched from an alcohol extract.

15. The composition of claim 1 , further comprising an adjuvant, excipient or carrier.

16. The composition of claim 15 , wherein the adjuvant, excipient or carrier is selected from one or more of calcium-based salts, silica, boron, histidine, glucosamine sulfate, chondroitin sulfate, copper gluconate, cellulose, dextrose, saline, water, oil, vitamin D, and shark and bovine cartilage.

Assignees

• Unigen Inc

Inventors

• Jia Qi

Classifications

• A61P37/02

  Immunomodulators · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title