Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent

Patent metadata

Field	Value
Publication number	US-9655940-B2
Application number	US-27992506-A
Country	US
Kind code	B2
Filing date	Apr 17, 2006
Priority date	Apr 30, 2002
Publication date	May 23, 2017
Grant date	May 23, 2017

Abstract

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.

First claim

The invention claimed is:

1. A composition comprised of a mixture of an extract derived from Scutellaria enriched for Free-B-ring flavonoids containing baicalin and an extract derived from Acacia enriched for flavans containing catechin or epicatechin, wherein the ratio of Free-B-ring flavonoid:flavan in the composition is about 85:15.

2. The composition of claim 1 , wherein at least 80% of the total weight of the composition comprises Free-B-ring flavonoids and flavans.

3. The composition of claim 1 , wherein the major active components of the mixture are the Free-B-ring flavonoids and the flavans.

4. The composition of claim 1 , wherein the major active ingredients of the mixture are baicalin, catechin, and epicatechin.

5. The composition of claim 1 , wherein the Free-B-ring flavonoids and the flavans are enriched from a plant part selected from the group consisting of stems, stem barks, trunks, trunk barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers and other reproductive organs, leaves and other aerial parts.

6. The composition of claim 1 , wherein the Free-B-ring flavonoids are enriched from Scutellaria baicalensis or Scutellaria orthocalyx.

7. The composition claim 1 , wherein said flavans are enriched from a plant species selected from the group consisting of the Acacia catechu, Acacia concinna, Acacia farnesiana, Acacia Senegal, Acacia speciosa, Acacia arabica, A. caesia, A. pennata, A. sinuata. A. mearnsii, A. picnantha, A. dealbata, A. auriculiformis, A. holoserecia and A. mangium.

8. The composition of claim 1 , wherein the Free-B-ring flavonoids are enriched from Scutellaria baicalensis and the flavans are enriched from Acacia catechu.

9. The composition of claim 1 , further comprising an adjuvant, excipient or carrier.

10. The composition of claim 9 , wherein the adjuvant, excipient or carrier is selected from one or more of calcium-based salts, silica, boron, histidine, glucosamine sulfate, chondroitin sulfate, copper gluconate, cellulose, dextrose, saline, water, oil, vitamin D, and shark and bovine cartilage.

Assignees

• Jia Qi
• Unigen Inc

Inventors

• Jia Qi

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P39/06

  Free radical scavengers or antioxidants · CPC title

• A61P37/02

  Immunomodulators · CPC title