Composition for treating atopic dermatitis comprising extracts of bamboo and scutellaria

Patent metadata

Field	Value
Publication number	US-9623068-B2
Application number	US-201414288138-A
Country	US
Kind code	B2
Filing date	May 27, 2014
Priority date	Oct 12, 2006
Publication date	Apr 18, 2017
Grant date	Apr 18, 2017

Abstract

The present invention relates to a composition comprised of a plant extract as an active component, specifically, Bamboo extract and Scutellaria extract, for the treatment and prevention of atopic dermatitis. The present invention is a natural ingredient can be obtained from a plant. The present invention can control immune responses by inhibiting the release of histamine and leukotrien, and thus, has effect in the treatment or prevention of allergic diseases, inflammatory diseases and skin diseases, specifically atopic dermatitis. The present invention has been proven safe and beneficial effecting the treatment of atopic dermatitis through clinical trials, and thus, can be used for the treatment and prevention of atopic dermatitis.

First claim

The invention claimed is:

1. A method for inhibiting release of histamine, leukotriene or both, in a human subject in need thereof comprising administering to the subject a composition comprising effective amounts of a Bamboo extract and a Scutellaria extract, wherein the weight ratio of the Bamboo extract to the Scutellaria extract ranges from 1:3 to 3:1, and wherein the composition inhibits release of histamine, leukotriene or both in the subject.

2. The method according to claim 1 , wherein the Bamboo extract is from a Bamboo genus selected from Phyllostachys, Sasa, Pseudosasa , or a combination thereof.

3. The method according to claim 2 , wherein the Phyllostachys is Phyllostachys bambusoides, Phyllostachys comprossa, Phyllostachys edulis, Phyllostachys pubescence, Phyllostachys nigra, Phyllostachys nigra var. henonis , or Phyllostachys nigra for punctate.

4. The method according to claim 2 , wherein the Sasa is Sasa coreana Nakai, Sasa coreana, Sasa kurilensis, Sasa queipaertensis, Sasa borealis, Sasa borealis var. chiisanensis , or Sasa borealis var. gracilis.

5. The method according to claim 2 , wherein the Pseudosasa is Pseudosasa japonica or Pseudosasa japonica var. purpurascens.

6. The method according to claim 1 , wherein the Bamboo extract is a water-insoluble fraction of a 50-90% ethanol extract.

7. The method according to claim 6 , wherein the Scutellaria extract is obtained by extraction with water, methanol, ethanol or a mixture thereof.

8. The method according to claim 1 , wherein the Bamboo extract is an ethanol-soluble fraction of a hot water extract.

9. The method according to claim 8 , wherein the Scutellaria extract is obtained by extraction with water, methanol, ethanol or a mixture thereof.

10. The method according to claim 1 , wherein inhibiting release of histamine, leukotriene, or both reduces an allergic reaction.

11. The method according to claim 1 , wherein inhibiting release of histamine, leukotriene, or both treats atopic dermatitis.

12. The method according to claim 1 , wherein inhibiting release of histamine, leukotriene, or both treats erythema, edema, papulation, oozing, crust, excoriation, lichenification or skin dryness.

13. The method according to claim 1 , wherein inhibiting release of histamine, leukotriene, or both treats decreases transdermal moisture loss.

14. The method according to claim 1 , wherein the composition is formulated with a pharmaceutically acceptable carrier or excipient.

15. The method according to claim 1 , wherein the composition is administered topically.

16. The method according to claim 1 , wherein the composition is prepared as a gel, ointment, or emulsion.

17. The method according to claim 16 , wherein the composition is administered topically.

Assignees

• Unigen Inc

Inventors

• Woo Sung-Sick
• Kim Dong-Seon
• Lee Young-Chul
• Son Eunjung

Classifications

• A61P37/02

  Immunomodulators · CPC title

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61K36/899 Primary

  Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane · CPC title

• A61K36/539

  Scutellaria (skullcap) · CPC title