Methods for Reducing the Occurrence of Hot Flashes

Patent metadata

Field	Value
Publication number	US-2016166535-A1
Application number	US-201414906695-A
Country	US
Kind code	A1
Filing date	Jul 22, 2014
Priority date	Jul 22, 2013
Publication date	Jun 16, 2016
Grant date	—

Abstract

The present invention provides methods to reduce the number and severity of hot flashes utilizing tocotrienols. In particular, symptoms of perimenopause and menopause may be treated using the present methods. The present invention also provides methods to increase tissue concentrations of tocotrienols.

First claim

1 . (canceled)

2 . (canceled)

3 . (canceled)

4 . A method to ameliorate the symptoms of perimenopause, menopause, and/or ameliorate hot flashes in a subject receiving androgen deprivation therapy, comprising:
a) administering to the subject having symptoms of perimenopause at least one tocotrienol selected from the group consisting of: d-alpha-tocotrienol; d-beta-tocotrienol; d-gamma-tocotrienol; and d-delta-tocotrienol; and b) ameliorating the symptoms of perimenopause in the subject.

5 . (canceled)

6 . (canceled)

7 . The method of claim 4 , wherein the tocotrienol is administered according to a dose of at least one of: Table A; Table B; Table C; Table D; and Table E.

8 . The method of claim 4 , which further comprises administering an additional pharmaceutical composition.

9 . The method of claim 4 , which further comprises administering a composition selected from the group consisting of: progesterone; and estrogen.

10 . The method of claim 4 , wherein the tocotrienol administered comprises tocopherol, by weight percent of total, less than a percent selected from the group consisting of: 50%; 40%; 30%; 20%; 15%; 10%; 5%; and 1%.

11 . The method of claim 4 , wherein the tocotrienol is substantially free of tocopherol.

12 . (canceled)

13 . (canceled)

14 . (canceled)

15 . The method of claim 4 , wherein the tocotrienol is 400 mg to 800 mg per day of Tocovid SupraBio.

16 . (canceled)

17 . The method of claim 4 , comprising: a.) administering at least one daily 400 mg to 800 mg dose of tocotrienol formulation to a subject with hot flashes, wherein the tocotrienol formulation comprises approximately 123 mg to approximately 146 mg d-alpha tocotrienol; approximately 16 mg to approximately 32 mg d-beta tocotrienol; approximately 225 mg to approximately 450 mg d-gamma tocotrienol; and approximately 51 mg to approximately 102 mg d-delta tocotrienol; and b.) reducing the severity of hot flashes in the subject.

18 . (canceled)

19 . The method of claim 4 , comprising: a.) administering at least one daily 400 mg to 800 mg dose of tocotrienol formulation to a subject with hot flashes, wherein the tocotrienol formulation comprises approximately 123 mg to approximately 146 mg d-alpha tocotrienol; approximately 16 mg to approximately 32 mg d-beta tocotrienol; approximately 225 mg to approximately 450 mg d-gamma tocotrienol; and approximately 51 mg to approximately 102 mg d-delta tocotrienol; and b.) ameliorating the symptoms of perimenopause in the subject.

20 . The method of claim 4 , comprising: a.) administering at least one daily 400 mg to 800 mg dose of tocotrienol formulation to a subject with hot flashes, wherein the tocotrienol formulation comprises approximately 123 mg to approximately 146 mg d-alpha tocotrienol; approximately 16 mg to approximately 32 mg d-beta tocotrienol; approximately 225 mg to approximately 450 mg d-gamma tocotrienol; and approximately 51 mg to approximately 102 mg d-delta tocotrienol; and b.) ameliorating the symptoms of menopause in the subject.

Assignees

• Ohio State Innovation Foundation

Inventors

• Sen Chandan K
• Roy Sashwati
• Khanna Savita
• Rink Cameron

Classifications

• A61K9/4858

  Organic compounds · CPC title

• A61K9/4875

  Compounds of unknown constitution, e.g. material from plants or animals (oils, fats, waxes, shellac A61K9/4858) · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K9/107

  Emulsions {; Emulsion preconcentrates; Micelles (composition of emulsions A61K47/00)} · CPC title

• A61K9/4866

  Organic macromolecular compounds · CPC title