Bioreactor including a rocking device

Patent metadata

Field	Value
Publication number	US-9738863-B2
Application number	US-201213984887-A
Country	US
Kind code	B2
Filing date	Feb 21, 2012
Priority date	Feb 23, 2011
Publication date	Aug 22, 2017
Grant date	Aug 22, 2017

Abstract

The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray ( 4 ) for holding said at least one bag, a rocking device for limited rocking motions of the tray ( 4 ) around a rocking axis ( 2 ). According to the invention the bioreactor comprises a device ( 6,7,8,9 ) for enabling swinging of the tray ( 4 ) around a second axis ( 7 ) parallel to and distanced from the rocking axis ( 2 ).

First claim

The invention claimed is:

1. A bioreactor device, comprising:
a tray having a free end;
an intermediate plate being detachably connected to the tray;
a platform having a free end and an end that is pivotally connected to an end of the intermediate plate the connection between the intermediate plate and the platform forming a first axis;
a housing device comprising a pivoting mechanism for pivoting the platform;
wherein the housing device is arranged parallel to the platform;
wherein a center of the housing device is pivotally connected to a center of the platform, the connection between the platform and the housing device forming a second axis;
wherein (i) the first axis enables the tray free end to pivot upwardly from the platform free end and (ii) the second axis enables the free end of the platform to pivot upwardly from the housing device; and
wherein, the first axis and the second axis together enable the tray to pivotally extend to an upright position.

2. The bioreactor device of claim 1 , wherein the intermediate platform comprises at least one gas spring damper.

3. The bioreactor device of claim 2 , further comprising one of (i) a set of spring dampers for releasably locking the tray in set positions.

4. The bioreactor device of claim 2 , wherein the tray is detachably attached to the intermediate plate which is attached to the rocking platform by a hinge connection located at a distance from a first axis and to which one end of at least one gas spring damper is pivotally attached.

5. The bioreactor device of claim 1 , wherein the tray is pivotable around an axis being substantially perpendicular to a plane of the tray.

6. The bioreactor device of claim 4 , wherein a yoke in one end is pivotally attached to the intermediate plate, and an opposite end of the yoke is insertable into one of (i) a set of spring dampers provided on the rocking platform for locking the intermediate plate in one or more set positions.

7. The bioreactor device of claim 2 , wherein the intermediate platform is configured to pivot the tray at an angle with respect to a plane parallel to a first axis.

8. The bioreactor device of claim 7 , wherein when the tray is pivoted at the angle, an at least one reactor vessel remains claimed to the tray.

9. The bioreactor device of claim 1 , wherein the second axis further enables the platform free end and the platform end attached to the tray to pivot between an angle of +alpha and an angle of −alpha with respect to a horizontal line.

10. The bioreactor device of claim 1 , wherein the first axis and second axis together enable the tray to extend upright at an angle of about 72 degrees with respect to a horizontal line.

11. A bioreactor, comprising:
a first device configured to provide a rocking motion for a platform mounted thereto, the rocking motion characterized by ends of the platform being moved back and forth and above and below a horizontal line perpendicular to a first axis; and
a second device configured to adjust a position of a tray to a set position;
wherein the tray is detachably connected to an intermediate plate, the intermediate plate being mounted on one of the platform ends;
wherein the set a position; with respect to the platform, is characterized by a second axis by which the tray is pivoted at an angle against a pivot point disposed at the end of the platform;
wherein, the first axis and the second axis together enable the tray to pivotally extend to an upright position.

12. A device for use of a bioreactor, comprising: a tray being detachably connected to an intermediate plate;
wherein an end of the intermediate plate is pivotally connected to an end of a platform;
wherein a position of the tray with respect to the platform is adjustable to a first angle defined by a first axis;
wherein the platform is disposed around a second axis and movable according to a rocking motion characterized by each end of the platform being moveable to a second angle, which is defined by the second axis, either above or below a horizontal line perpendicular to the second axis; and
wherein, the first axis and the second axis together enable the first angle and the second angle to pivotally extend the tray to an upright position.

Assignees

• Andersson Andreas
• Carlsson Johan L
• Elnegard Christian
• Eriksson Henrik K
• Falkman Thomas
• Fricking Patric
• Pauler Linnea
• Petterson Claes
• Ge Healthcare Bio Sciences Ab

Inventors

• Andersson Andreas
• Carlsson Johan L
• Elnegard Christian
• Eriksson Henrik K
• Falkman Thomas
• Fricking Patric
• Pauler Linnea
• Petterson Claes

Classifications

• C12M23/14

  Bags · CPC title

• C12M27/16 Primary

  Vibrating; Shaking; Tilting · CPC title

• C12M23/50

  Means for positioning or orientating the apparatus (C12M41/08 takes precedence) · CPC title

• B01F11/0017

  Operations & Transport · mapped topic

• B01F15/0085

  Operations & Transport · mapped topic