Neisseria meningitidis compositions and methods thereof
US-9561269-B2 · Feb 7, 2017 · US
Neisseria meningitidis composition and methods thereof
US9724402B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9724402-B2 |
| Application number | US-201615237005-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 15, 2016 |
| Priority date | Mar 9, 2012 |
| Publication date | Aug 8, 2017 |
| Grant date | Aug 8, 2017 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
In one aspect, the invention relates to an isolated polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 71 in another aspect, the invention relates to an immunogenic composition including an isolated non-lipidated, non-pyruvylated ORF2086 polypeptide from Neisseria meningitidis serogroup B, and at least one conjugated capsular saccharide from a meningococcal serogroup.
First claim
Opening claim text (preview).
What is claimed is: 1. An isolated non-lipidated and non-pyruvylated polypeptide comprising an amino acid sequence set forth as SEQ ID NO: 68, wherein an N-terminal cysteine at position 1 is deleted, as compared to SEQ ID NO: 15. 2. An isolated non-lipidated and non-pyruvylated polypeptide comprising an amino acid sequence set forth as SEQ ID NO: 68, wherein an N-terminal cysteine at position 1 is substituted, as compared to SEQ ID NO: 15. 3. The polypeptide according to claim 1 , wherein the polypeptide is immunogenic. 4. The polypeptide according to claim 1 , wherein the polypeptide does not exhibit a mass shift of about +70 Da compared to the corresponding non-lipidated polypeptide as measured by mass spectrometry. 5. The isolated polypeptide according to claim 1 , wherein the amino acid sequence consists of the sequence set forth in SEQ ID NO: 68. 6. The isolated polypeptide according to claim 5 , wherein the polypeptide is encoded by the nucleic acid sequence SEQ ID NO: 69. 7. The isolated polypeptide according to claim 1 wherein the amino acid sequence consists of the sequence set forth as SEQ ID NO: 64. 8. The isolated polypeptide according to claim 7 , wherein the polypeptide is encoded by the nucleic acid sequence SEQ ID NO: 63. 9. An immunogenic composition comprising the polypeptide as in any of claims 1 , 3 , 4 , 5 , 6 , 7 , and 6 . 10. The composition according to claim 9 , further comprising an adjuvant.
Assignees
Inventors
Classifications
Antibacterial agents · CPC title
Immunostimulants · CPC title
Neisseriaceae (F) · CPC title
Saponins; Quil A; QS21; ISCOMS · CPC title
Lipids, e.g. in lipopeptides · CPC title
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- What does patent US9724402B2 cover?
- In one aspect, the invention relates to an isolated polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 71 in another aspect, the invention relates to an immunogenic composition including an isolated non-lipidated, non-pyruvylated ORF2086 polypeptide from Neisseria meningitidis serogroup B, and at least one conjugated capsular saccharide from a meningoco…
- Who is the assignee on this patent?
- Pfizer
- What technology area does this patent fall under?
- Primary CPC classification C07K14/22. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 08 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 7 related publications on this page (citations in our corpus or others sharing the same primary CPC).