Neisseria meningitidis compositions and methods thereof
US-8986710-B2 · Mar 24, 2015 · US
Neisseria meningitidis compositions and methods thereof
US9561269B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9561269-B2 |
| Application number | US-201514604620-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 23, 2015 |
| Priority date | Mar 9, 2012 |
| Publication date | Feb 7, 2017 |
| Grant date | Feb 7, 2017 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
In one aspect, the invention relates to an isolated polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 71. In another aspect, the invention relates to an immunogenic composition including an isolated non-lipidated, non-pyruvylated ORF2086 polypeptide from Neisseria meningitidis serogroup B, and at least one conjugated capsular saccharide from a meningococcal serogroup.
First claim
Opening claim text (preview).
What is claimed is: 1. An isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 76. 2. The isolated polypeptide according to claim 1 , wherein the polypeptide is lipidated. 3. The isolated polypeptide according to claim 1 , wherein the polypeptide is non-lipidated. 4. The isolated polypeptide according to claim 1 , wherein the polypeptide is immunogenic. 5. An isolated polypeptide comprising the sequence set forth in SEQ ID NO: 76, wherein the cysteine at position 1 is deleted. 6. The isolated polypeptide according to claim 5 , wherein the polypeptide does not exhibit a mass shift of about +70 Da compared to the corresponding non-lipidated polypeptide as measured by mass spectrometry. 7. An isolated polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 76. 8. The isolated polypeptide according to claim 7 , wherein the polypeptide is lipidated. 9. The isolated polypeptide according to claim 7 , wherein the polypeptide is non-lipidated. 10. The isolated polypeptide according to claim 7 , wherein the polypeptide is immunogenic. 11. An immunogenic composition comprising the polypeptide as in any one of claims 1 - 10 . 12. The composition of claim 11 , further comprising an adjuvant.
Assignees
Inventors
Classifications
Immunostimulants · CPC title
Antibacterial agents · CPC title
Neisseriaceae (F) · CPC title
Lipids, e.g. in lipopeptides · CPC title
- C07K14/22Primary
from Neisseriaceae (F) · CPC title
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Frequently asked questions
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- What does patent US9561269B2 cover?
- In one aspect, the invention relates to an isolated polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 71. In another aspect, the invention relates to an immunogenic composition including an isolated non-lipidated, non-pyruvylated ORF2086 polypeptide from Neisseria meningitidis serogroup B, and at least one conjugated capsular saccharide from a meningoc…
- Who is the assignee on this patent?
- Pfizer
- What technology area does this patent fall under?
- Primary CPC classification C07K14/22. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 07 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).