Sample analysis systems and methods of use thereof

Patent metadata

Field	Value
Publication number	US-9704700-B2
Application number	US-201515317801-A
Country	US
Kind code	B2
Filing date	Jun 16, 2015
Priority date	Jun 16, 2014
Publication date	Jul 11, 2017
Grant date	Jul 11, 2017

Abstract

The invention generally relates to sample analysis systems and methods of use thereof. In certain aspects, the invention provides a system for analyzing a sample that includes an ion generator configured to generate ions from a sample. The system additionally includes an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas, and a detector that receives and detects the separated ions.

First claim

What is claimed is:

1. A system for analyzing a sample, the system comprising:
an ion generator configured to generate ions from a sample;
an ion separator configured to separate at or above atmospheric pressure the ions received from the ion generator without use of laminar flowing gas; and
a detector that receives and detects the separated ions.

2. The system according to claim 1 , wherein the ion generator comprises:
an ionization source; and
an ion injector configured to interface with the ionization source such that ions produced by the ionization source are received by the ion injector.

3. The system according to claim 2 , wherein the ionization source is out-of-line with the detector.

4. The system according to claim 2 , wherein the ion injector is maintained at or above atmospheric pressure.

5. The system according to claim 2 , wherein the ion injector comprises a cavity and one or more wire meshes that receive the ions produced by the ionization source.

6. The system according to claim 2 , wherein the ion injector receive the ions produced by the ionization source and transmits them as a focused beam to the ion separator.

7. The system according to claim 2 , wherein the ion separator comprises a chamber and a plurality of electrodes that are configured such that upon application of voltage to the electrodes, ions received from the ion injector are separated as they travel through the chamber.

8. The system according to claim 7 , wherein the plurality of electrodes are three curved electrodes.

9. The system according to claim 8 , wherein each of the three curved electrodes are separated from each other by non-conductive spacer.

10. The system according to claim 9 , wherein at least one of the three curved electrodes comprises an opening through which a probe may be inserted.

11. The system according to claim 1 , wherein the detector is a mass spectrometer or a miniature mass spectrometer.

12. A method for analyzing a sample, the method comprising:
generating ions from a sample at or above atmospheric pressure;
separating the ions at or above atmospheric pressure without use of laminar flowing gas; and
detecting the separated ions, thereby analyzing the sample.

13. The method according to claim 12 , wherein the detecting step is at or above atmospheric pressure.

14. The method according to claim 12 , wherein the detecting step is below atmospheric pressure.

15. The method according to claim 12 , wherein detecting comprises receiving the ions into a mass spectrometer or a miniature mass spectrometer.

16. The method according to claim 12 , wherein the sample is selected from the group consisting of: a mammalian sample, a food sample, and a drug product sample.

17. The method according to claim 12 , wherein the separating step comprises transferring the ions into an ion separator that comprises a chamber and a plurality of electrodes that are configured such that upon application of voltage to the electrodes, the ions are separated as they travel through the chamber.

18. The method according to claim 17 , wherein the plurality of electrodes are three curved electrodes.

19. The method according to claim 18 , wherein each of the three curved electrodes are separated from each other by non-conductive spacer.

20. A method for detecting a reaction product, the method comprising generating ions at or above atmospheric pressure;
separating the ions at or above atmospheric pressure without use of laminar flowing gas;
introducing neutral molecules to the separated ions;
reacting a portion of the separated ions with the neutral molecules to produce a reaction product; and
detecting the reaction product.

Assignees

• Purdue Research Foundation

Inventors

• Cooks Robert Graham
• Baird Zane
• Wei Pu

Classifications

• G01N27/622

  Ion mobility spectrometry · CPC title

• H01J49/142

  using a solid target which is not previously vapourised · CPC title

• H01J49/061

  Ion deflecting means, e.g. ion gates · CPC title

• H01J49/24 Primary

  Vacuum systems, e.g. maintaining desired pressures · CPC title

• G01N27/623

  combined with mass spectrometry · CPC title