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Botanical extract from the aqueous stream of the palm oil milling process for the prevention and inhibition of oxidative stress and haemolysis in human red blood cells
US9669065B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9669065-B2 |
| Application number | US-201414158606-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 17, 2014 |
| Priority date | Sep 11, 2007 |
| Publication date | Jun 6, 2017 |
| Grant date | Jun 6, 2017 |
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- Title
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Abstract
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The invention provides a composition for the prevention and inhibition of oxidative stress and hemolysis in human red blood cell wherein said composition compounds obtained from the aqueous stream of palm oil milling (palm oil vegetation liquor), in particular from vegetative liquor from the milling of palm oil fruit.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for inhibition of hemolysis in human red blood cells, said method comprising contacting red blood cells with an effective amount of a composition comprising phenolic acids and flavonoids obtained from palm oil vegetation liquor to inhibit hemolysis in the red blood cells, wherein the effective amount of the composition is between 0.025 and 0.1 mM. 2. The method of claim 1 , wherein the composition is able to delay 2,2′-azobis-(2-amidinopropane) dihydrocloride (AAPH) induced hemolysis in the red blood cells. 3. The method of claim 2 , wherein the composition is sufficient to reduce the percentage of hemolysis to 10% after 300 minutes of exposure to 50 mM AAPH. 4. A method for inhibition of oxidative stress in human red blood cells, said method comprising contacting red blood cells with a composition comprising an effective amount of phenolic acids and flavonoids obtained from palm oil vegetation liquor to inhibit oxidative stress in the red blood cells, wherein the effective amount of the composition is between 0.025 and 0.1 mM.
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Classifications
Free radical scavengers or antioxidants · CPC title
- A61K36/889Primary
Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto · CPC title
Drugs for disorders of the blood or the extracellular fluid · CPC title
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Frequently asked questions
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- What does patent US9669065B2 cover?
- The invention provides a composition for the prevention and inhibition of oxidative stress and hemolysis in human red blood cell wherein said composition compounds obtained from the aqueous stream of palm oil milling (palm oil vegetation liquor), in particular from vegetative liquor from the milling of palm oil fruit.
- Who is the assignee on this patent?
- Malaysian Palm Oil Board
- What technology area does this patent fall under?
- Primary CPC classification A61K36/889. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jun 06 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).