Dialysis precursor composition

Patent metadata

Field	Value
Publication number	US-9655922-B1
Application number	US-201715441549-A
Country	US
Kind code	B1
Filing date	Feb 24, 2017
Priority date	Jun 20, 2011
Publication date	May 23, 2017
Grant date	May 23, 2017

Abstract

The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution. The dialysis acid precursor composition consists of powder components comprising sodium chloride, at least one dry acid and at least one calcium salt, and optionally potassium salt, magnesium salt, and glucose. In an embodiment, the at least one calcium salt and the optional glucose are present as anhydrous components in the dialysis acid precursor composition.

First claim

What is claimed is:

1. A ready-for-use dialysis solution comprising:
a bicarbonate containing concentrate; and
a dialysis acid concentrate solution comprising powder components mixed with water, the powder components comprising (1) a sodium chloride powder, (2) at least one dry acid powder, and (3) an anhydrous calcium chloride powder in a quantity such that a concentration of about 30-125 mM calcium ions is provided in the dialysis acid concentrate solution.

2. The ready-for-use dialysis solution of claim 1 , wherein the at least one dry acid is selected from the group comprising lactic acid, citric acid, gluconic acid, glucono-δ-lactone, N-acetyl cysteine and α-lipoic acid.

3. The ready-for-use dialysis solution of claim 1 , wherein the powder components comprise potassium salt in a quantity such that a concentration of about 0-4 mM potassium ions is provided in the ready-for-use dialysis solution.

4. The ready-for-use dialysis solution of claim 1 , wherein the powder components comprise magnesium salt in a quantity such that a concentration of about 0.25-1 mM magnesium ions is provided in the ready-for-use dialysis solution.

5. The ready-for-use dialysis solution of claim 1 , wherein the powder components comprise anhydrous glucose in a quantity such that a concentration of about 0-2 g/l glucose is provided in the ready-for-dialysis solution.

6. The ready-for-use dialysis solution of claim 1 , wherein the sodium chloride is in a quantity such that a concentration of about 130-150 mM sodium ions is provided in the ready-for-use dialysis solution.

7. The ready-for-use dialysis solution of claim 1 , wherein the anhydrous calcium chloride is in a quantity such that a concentration of about 1-2.5 mM calcium ions is provided in the ready-for-use dialysis solution.

8. The ready-for-use dialysis solution of claim 1 , wherein the sodium chloride and the anhydrous calcium chloride are in a quantity such that a concentration of about 85-134 mM chloride ions is provided in the ready-for-use dialysis solution.

9. The ready-for-use dialysis solution of claim 1 , wherein the at least one dry acid is in a quantity such that a concentration of about 2-4 mEq/L acid is provided in the ready-for-use dialysis solution.

10. The ready-for-use dialysis solution of claim 1 , wherein the bicarbonate containing concentrate is in a quantity such that a concentration of about 20-40 mEq/L bicarbonate ions is provided in the ready-for-use dialysis solution.

11. The ready-for-use dialysis solution of claim 1 , wherein the ready-for-use dialysis solution is one selected from the group consisting of a dialysis solution, an infusion solution, a replacement solution, a rinsing solution, and a priming solution.

12. A method for forming a ready-for-use dialysis solution, the method comprising:
diluting a dialysis acid concentrate solution with a bicarbonate containing concentrate, the dialysis acid concentrate solution comprising powder components mixed with water, the powder components comprising (1) a sodium chloride powder, (2) at least one dry acid powder, and (3) an anhydrous calcium chloride powder in a quantity such that a concentration of about 30-125 mM calcium ions is provided in the dialysis acid concentrate solution.

13. The method of claim 12 , wherein the powder components comprise potassium salt in a quantity such that a concentration of about 0-4 mM potassium ions is provided in the ready-for-use dialysis solution.

14. The method of claim 12 , wherein the powder components comprise magnesium salt in a quantity such that a concentration of about 0.25-1 mM magnesium ions is provided in the ready-for-use dialysis solution.

15. The method of claim 12 , wherein the powder components comprise anhydrous glucose in a quantity such that a concentration of about 0-2 g/l glucose is provided in the ready-for-dialysis solution.

16. The method of claim 12 , wherein the sodium chloride is in a quantity such that a concentration of about 130-150 mM sodium ions is provided in the ready-for-use dialysis solution.

17. The method of claim 12 , wherein the anhydrous calcium chloride is in a quantity such that a concentration of about 1-2.5 mM calcium ions is provided in the ready-for-use dialysis solution.

18. The method of claim 12 , wherein the sodium chloride and the anhydrous calcium chloride are in a quantity such that a concentration of about 85-134 mM chloride ions is provided in the ready-for-use dialysis solution.

19. The method of claim 12 , wherein the at least one dry acid is in a quantity such that a concentration of about 2-4 mEq/L acid is provided in the ready-for-use dialysis solution.

20. The method of claim 12 , wherein the bicarbonate containing concentrate is in a quantity such that a concentration of about 20-40 mEq/L bicarbonate ions is provided in the ready-for-use dialysis solution.

Assignees

• Gambro Lundia Ab

Inventors

• Jansson Olof
• Linden Torbjorn
• Wieslander Anders

Classifications

• A61K33/10 Primary

  Carbonates; Bicarbonates · CPC title

• A61K9/0095

  Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006) · CPC title

• A61M1/1654

  Dialysates therefor · CPC title

• A61K31/7004 Primary

  Monosaccharides having only carbon, hydrogen and oxygen atoms · CPC title

• A61K31/194

  having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid · CPC title