Copolymers having polyisobutylene and biodegradable polymer segments

Patent metadata

Field	Value
Publication number	US-9631042-B2
Application number	US-201414539449-A
Country	US
Kind code	B2
Filing date	Nov 12, 2014
Priority date	Dec 31, 2008
Publication date	Apr 25, 2017
Grant date	Apr 25, 2017

Abstract

The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages.

First claim

The invention claimed is:

1. A medical article, comprising:
a tubular member including a polymeric region, the polymeric region including a copolymer comprising a plurality of polyisobutylene segments having a number average molecular weight of 20,000 or less and a plurality of hard biodegradable polymer segments; and
wherein the copolymer includes one or more linkages comprising a 1,2,3-triazole moiety.

2. The medical article of claim 1 , wherein the hard segments comprise a plurality of diisocyanate residues, a plurality of urethane linkages, a plurality of urea linkages, or a combination thereof.

3. The medical article of claim 1 , wherein the hard segments comprise a plurality of diisocyanate residues and wherein the diisocyanate residues comprise non-aromatic diisocyanate residues.

4. The medical article of claim 1 , wherein the hard segments comprise a plurality of diisocyanate residues wherein the diisocyanate residues comprise aromatic diisocyanate residues.

5. The medical article of claim 1 , wherein the hard segments comprise a plurality of diisocyanate residues wherein the diisocyanate residues comprise residues of an aromatic diisocyanate selected from 4,4′-methylenediphenyl diisocyanate, toluene diisocyanate, 1,5-naphthalene diisocyanate, para-phenylene diisocyanate, 3,3′-tolidene-4,4′diisocyanate, 3,3′-dimethyl-diphenylmethane-4,4′-diisocyanate, and combinations thereof.

6. The medical article of claim 1 , further comprising a plurality of chain extender residues.

7. The medical article of claim 6 , wherein the chain extender residues are selected from aliphatic diol residues, aromatic diol residues, aliphatic diamine residues and aromatic diamine residues.

8. The medical article of claim 6 , wherein the chain extender residues are selected from alpha,omega-C 1-C 10-alkane diol residues.

9. The medical article of claim 1 , comprising from 2 to 50 polyisobutylene segments.

10. The medical article of claim 1 , comprising from 2 to 50 biodegradable polymer segments.

11. The medical article of claim 1 , wherein the tubular member is a stent, a catheter, a lead, an orthopedic screw, a suture, a venous valve, a cardiac valve, a graft, an aneurysm coil, an adhesion prevention coating, a pelvic mesh, a hernia mesh, or a spinal disc replacement.

12. The medical article of claim 1 , wherein the polymeric region further comprises a therapeutic agent.

13. The medical article of claim 12 , wherein the therapeutic agent is an antirestenotic agent.

14. An implantable medical devices, comprising:
a stent having a polymeric region, the polymeric region including a copolymer comprising a plurality of polyisobutylene segments having a number average molecular weight of 20,000 or less and a plurality of hard biodegradable polymer segments; and
wherein the copolymer includes one or more linkages comprising a 1,2,3-triazole moiety.

Assignees

• Boston Scient Scimed Inc
• Univ Massachusetts Lowell
• The Univ Of Massachusetts Lowell

Inventors

• Boden Mark
• Schwarz Marlene C
• Strickler Frederick H
• Faust Rudolf
• Ojha Umaprasana
• Higashihara Tomoya

Classifications

• C08F299/04 Primary

  from polyesters · CPC title

• A61L27/165 Primary

  Rubbers · CPC title

• C08G69/08

  derived from amino-carboxylic acids · CPC title

• A61L27/54

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title

• A61L29/16

  Biologically active materials, e.g. therapeutic substances {(A61L29/048 takes precedence)} · CPC title