Dentinal tubule sealing material

Patent metadata

Field	Value
Publication number	US-9526675-B2
Application number	US-201414909803-A
Country	US
Kind code	B2
Filing date	Aug 4, 2014
Priority date	Aug 6, 2013
Publication date	Dec 27, 2016
Grant date	Dec 27, 2016

Abstract

The present invention provides a dentinal tubule sealing material excellent in durability of dentinal tubule sealing performance (acid resistance) and also in storage stability. The present invention relates to a dentinal tubule sealing material including tetracalcium phosphate particles (A), calcium hydrogen phosphate particles (B), calcium carbonate particles (C), and a non-aqueous dispersant (D), the dentinal tubule sealing material including 5 to 75 parts by weight of the tetracalcium phosphate particles (A), 10 to 70 parts by weight of the calcium hydrogen phosphate particles (B), and 2 to 50 parts by weight of the calcium carbonate particles (C) per 100 parts by weight of the total of the tetracalcium phosphate particles (A), the calcium hydrogen phosphate particles (B), and the calcium carbonate particles (C).

First claim

The invention claimed is:

1. A dentinal tubule sealing material, comprising:
tetracalcium phosphate particles;
calcium hydrogen phosphate particles;
calcium carbonate particles; and
a non-aqueous dispersant,
wherein the dentinal tubule sealing material comprises 5 to 75 parts by weight of the tetracalcium phosphate particles, 10 to 70 parts by weight of the calcium hydrogen phosphate particles, and 2 to 50 parts by weight of the calcium carbonate particles per 100 parts by weight of the total of the tetracalcium phosphate particles, the calcium hydrogen phosphate particles, and the calcium carbonate particles.

2. The dentinal tubule sealing material according to claim 1 ,
wherein the tetracalcium phosphate particles have an average particle diameter of 0.5 to 10 μm,
the calcium hydrogen phosphate particles have an average particle diameter of 0.1 to 7.5 μm, and
the calcium carbonate particles have an average particle diameter of 0.1 to 12 μm.

3. The dentinal tubule sealing material according to claim 1 , further comprising:
silica particles, metal oxide particles, or both, having an average particle diameter of 0.002 to 0.5 μm in an amount of 0.1 to 100 parts by weight per 100 parts by weight of the total of the tetracalcium phosphate particles, the calcium hydrogen phosphate particles, and the calcium carbonate particles.

4. The dentinal tubule sealing material according to claim 1 , further comprising:
a fluorine compound in an amount calculated as fluorine ion of 0.01 to 5 parts by weight, per 100 parts by weight of the dentinal tubule sealing material.

5. The dentinal tubule sealing material according to claim 1 , further comprising:
an alkali metal phosphate in an amount of 0.5 to 15 parts by weight per 100 parts by weight of the total of the tetracalcium phosphate particles, the calcium hydrogen phosphate particles, and the calcium carbonate particles.

6. The dentinal tubule sealing material according to claim 5 , wherein the alkali metal phosphate is at least one selected from the group consisting of disodium hydrogen phosphate and sodium dihydrogen phosphate.

7. The dentinal tubule sealing material according to claim 1 , wherein the calcium hydrogen phosphate particles comprise particles of at least one selected from the group consisting of dibasic calcium phosphate anhydrous, monobasic calcium phosphate anhydrous, dibasic calcium phosphate dihydrate, and monobasic calcium phosphate monohydrate.

8. The dentinal tubule sealing material according to claim 1 , wherein the calcium hydrogen phosphate particles comprise particles of dibasic calcium phosphate anhydrous.

9. The dentinal tubule sealing material according to claim 1 , wherein the non-aqueous dispersant is at least one selected from the group consisting of glycerin, ethylene glycol, propylene glycol, diglycerin, polyethylene glycol, and polypropylene glycol.

10. The dentinal tubule sealing material according to claim 1 , wherein the non-aqueous dispersant is at least one selected from the group consisting of glycerin, ethylene glycol, propylene glycol, and polyethylene glycol.

11. The dentinal tubule sealing material according to claim 1 , wherein the non-aqueous dispersant is at least one of glycerin and polyethylene glycol.

12. The dentinal tubule sealing material according to claim 1 , wherein the dentinal tubule sealing material comprises 10 to 60 parts by weight of the tetracalcium phosphate particles, 10 to 70 parts by weight of the calcium hydrogen phosphate particles, and 2 to 40 parts by weight of the calcium carbonate particles per 100 parts by weight of the total of the tetracalcium phosphate particles, the calcium hydrogen phosphate particles, and the calcium carbonate particles.

13. The dentinal tubule sealing material according to claim 1 ,
wherein the tetracalcium phosphate particles have an average particle diameter of 1.0 to 10 μm,
the calcium hydrogen phosphate particles have an average particle diameter of 0.5 to 5.0 μm, and
the calcium carbonate particles have an average particle diameter of 0.5 to 12 μm.

14. The dentinal tubule sealing material according to claim 12 ,
wherein the calcium hydrogen phosphate particles comprise particles of dibasic calcium phosphate anhydrous having an average particle diameter of 0.5 to 5.0 μm,
the non-aqueous dispersant is at least one of glycerin and polyethylene glycol,
the tetracalcium phosphate particles have an average particle diameter of 1.0 to 10 μm, and
the calcium carbonate particles have an average particle diameter of 0.5 to 12 μm.

15. The dentinal tubule sealing material according to claim 4 , wherein the fluorine compound comprises at least one compound selected from the group consisting of sodium fluoride, potassium fluoride, ammonium fluoride, lithium fluoride, cesium fluoride, magnesium fluoride, calcium fluoride, strontium fluoride, barium fluoride, copper fluoride, zirconium fluoride, aluminum fluoride, tin fluoride, sodium monofluorophosphate, potassium monofluorophosphate, hydrofluoric acid, titanium sodium fluoride, titanium potassium fluoride, hexylamine hydrofluoride, laurylamine hydrofluoride, glycine hydrofluoride, alanine hydrofluoride, fluorosilane, and diamine silver fluoride.

16. The dentinal tubule sealing material according to claim 4 , wherein the fluorine compound comprises at least one compound selected from the group consisting of sodium fluoride, sodium monofluorophosphate, and tin fluoride.

17. The dentinal tubule sealing material according to claim 5 , wherein the alkali metal phosphate has an average particle diameter of 1.0 to 12 μm.

18. The dentinal tubule sealing material according to claim 1 , further comprising:
silica particles having an average particle diameter of 0.002 to 0.5 μm in an amount of 0.1 to 100 parts by weight per 100 parts by weight of the total of the tetracalcium phosphate particles, the calcium hydrogen phosphate particles, and the calcium carbonate particles.

19. The dentinal tubule sealing material according to claim 1 , further comprising:
silica particles having an average particle diameter of 0.002 to 0.5 μm in an amount of 0.1 to 100 parts by weight per 100 parts by weight of the total of the tetracalcium phosphate particles, the calcium hydrogen phosphate particles, and the calcium carbonate particles;
at least one of sodium fluoride, sodium monofluorophosphate, and tin fluoride, in an amount calculated as fluorine ion of 0.01 to 5 parts by weight, per 100 parts by weight of the dentinal tubule sealing material; and
at least one of disodium hydrogen phosphate and sodium dihydrogen phosphate, in an amount of 0.5 to 15 parts by weight per 100 parts by weight of the total of the tetracalcium phosphate particles, the calcium hydrogen phosphate particles, and the calcium carbonate particles.

20. The dentinal tubule sealing material according to claim 10 , wherein the non-aqueous dispersant is included in an amount of 20 to 90 parts by weight per 100 parts by weight of the dentinal tubule sealing material.

Assignees

• Kuraray Noritake Dental Inc

Inventors

• Hatanaka Kenji
• Ishihara Shumei

Classifications

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title

• A61K6/54

  Filling; Sealing · CPC title

• A61K6/17

  Particle size · CPC title

• A61K6/70 Primary

  comprising inorganic additives · CPC title

• A61K8/24 Primary

  Phosphorous; Compounds thereof · CPC title