Oral care compositions

Patent metadata

Field	Value
Publication number	US-9717662-B2
Application number	US-201314770142-A
Country	US
Kind code	B2
Filing date	Mar 15, 2013
Priority date	Mar 15, 2013
Publication date	Aug 1, 2017
Grant date	Aug 1, 2017

Abstract

Described herein are oral care compositions comprising an effective amount of aluminum chlorohydrate suspended in a carrier for preventing, reducing or inhibiting dentinal hypersensitivity, the aluminum chlorohydrate exhibiting a SEC chromatogram having a SEC Peak 4 to Peak 3 intensity ratio of at least 7 and a Peak 4 intensity greater than a Peak 5 intensity; and methods of using the same.

First claim

We claim:

1. An oral care composition comprising:
an effective amount of aluminum chlorohydrate suspended in a carrier for preventing, reducing or inhibiting dentinal hypersensitivity;
wherein the aluminum chlorohydrate has an aluminum to chloride molar ratio of from about 0.5:1 to about 3:1, and
wherein the aluminum chlorohydrate exhibits a size exclusion chromatography (“SEC”) chromatogram having an SEC Peak 4 to Peak 3 intensity ratio of at least 7:1, and an SEC Peak 4 intensity greater than an SEC Peak 5 intensity.

2. The composition of claim 1 , wherein the composition is substantially anhydrous.

3. The composition of claim 1 , wherein the carrier is hydrophobic.

4. The composition claim 3 , wherein the hydrophobic carrier comprises an ingredient selected from: a fatty acid ester of glycerol; an oil selected from a vegetable oil, a synthetic oil or a mineral oil; a wax; a silicone oil or fluid; an alkylene glycol; a polyalkylene glycol; and a combination of two or more thereof.

5. The composition of claim 3 , wherein the hydrophobic carrier comprises a C 6-12 fatty acid ester of glycerol.

6. The composition of claim 1 , further comprising at least one buffer selected from glycine and betaine.

7. The composition of claim 1 , wherein the aluminum chlorohydrate is present in an amount of from 0.01 wt. % to 20 wt. % of a total weight of the composition.

8. The composition of claim 1 , wherein the aluminum chlorohydrate has an SEC Peak 4 area of at least 50% of a total area of Peaks 1, 2, 3, 4, 5, and 6 in the SEC chromatogram.

9. The composition of claim 1 , wherein the aluminum chlorohydrate has an SEC Peak 3 area of less than about 10% of a total area of Peaks 1, 2, 3, 4, 5, and 6 in the SEC chromatogram.

10. The composition of claim 1 , wherein the aluminum chlorohydrate has an SEC Peak 5 area of less than about 30% of a total area of Peaks 1, 2, 3, 4, 5, and 6 in the SEC chromatogram.

11. The composition of claim 1 , wherein the aluminum chlorohydrate has an SEC Peak 1 area of less than about 10% of a total area of Peaks 1, 2, 3, 4, 5, and 6 in the SEC chromatogram, and an SEC Peak 2 area of less than about 10% of the total area of Peaks 1, 2, 3, 4, 5, and 6 in the SEC chromatogram.

12. The composition of claim 1 , wherein the aluminum chlorohydrate has an SEC Peak 4 area of 95% to 100% of a total area of Peaks 1, 2, 3, 4, 5, and 6 in the SEC chromatogram, no SEC Peak 3 area in the SEC chromatogram, and no SEC Peak 5 area in the SEC chromatogram.

13. The composition of claim 1 , wherein the composition is a mouthrinse, a mouthwash, or a toothpaste.

14. A method of preventing, reducing or inhibiting dentinal hypersensitivity, the method comprising:
applying an effective amount of the composition of claim 1 to an oral cavity of a subject in need thereof.

15. A method of occluding dentin tubules, the method comprising administering the composition of claim 1 to a subject in need thereof.

16. An oral care care composition, comprising:
an effective amount of aluminum chlorohydrate suspended in a carrier for preventing, reducing, or inhibiting dentinal hypersensitivity;
wherein the aluminum chlorohydrate is formed from an aluminum salt, a buffer comprising glycine or betaine, and an inorganic base, and
wherein the aluminum chlorohydrate exhibits a size exclusion chromatography (“SEC”) chromatogram having an SEC Peak 4 to Peak 3 intensity ratio of at least 7:1, and an SEC Peak 4 intensity greater than an SEC Peak 5 intensity.

17. The composition of claim 16 , wherein the aluminum chlorohydrate has an aluminum to chloride molar ratio of about 0.3:1.

18. The composition of claim 16 , wherein the aluminum chlorohydrate has an aluminum to chloride molar ratio of about 0.4:1.

19. An oral care composition, comprising:
an effective amount of aluminum chlorohydrate suspended in a carrier for preventing, reducing, or inhibiting dentinal hypersensitivity;
wherein the aluminum chlorohydrate is formed from an aqueous solution of an aluminum salt, a buffer, and in inorganic base, so that the aqueous solution has an OH:Al molar ratio of about 2:1 to about 2.6:1, and
wherein the aluminum chlorohydrate exhibits a size exclusion chromatography (“SEC”) chromatogram having an SEC Peak 4 to Peak 3 intensity ratio of at least 7:1, and an SEC Peak 4 intensity greater than an SEC Peak 5 intensity.

20. The composition of claim 19 , wherein the buffer comprises glycine.

21. The composition of claim 19 , wherein the buffer comprises betaine.

Assignees

• Colgate Palmolive Co

Inventors

• Pan Long
• Maloney Venda Porter
• Reale Kristen
• Chopra Suman
• Masters James G
• Yuan Shaotang
• Du-Thumm Laurence

Classifications

• A61P1/00

  Drugs for disorders of the alimentary tract or the digestive system · CPC title

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title

• A61K6/70

  comprising inorganic additives · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K8/44

  Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof · CPC title