Methodology of dental caries detection

Patent metadata

Field	Value
Publication number	US-9662276-B2
Application number	US-201615062708-A
Country	US
Kind code	B2
Filing date	Mar 7, 2016
Priority date	Jun 16, 2015
Publication date	May 30, 2017
Grant date	May 30, 2017

Abstract

Disclosed are methods for detecting demineralization of a surface of a tooth, comprising a) contacting the tooth of a subject with an orally acceptable, binding composition comprising a binding agent that binds to a demineralized surface of the tooth; b) removing unbound binding compound; c) contacting the tooth with an orally acceptable, detector composition comprising a probe compound that reacts with the binding agent to form a visually detectable reaction product; and d) detecting formation of the reaction product as an indication of the presence or extent of surface demineralization of the tooth. Systems, kits, and compositions for practicing the methods are also provided.

First claim

The invention claimed is:

1. A kit for detecting demineralization of a surface of a tooth, comprising a) a first container comprising an orally acceptable, binding composition comprising iron (III) pyrophosphate (Fe(III)-PP); b) a second container comprising an orally acceptable, detector composition comprising gallic acid or an ester thereof that reacts with the Fe(III)-PP to form a visually detectable reaction product; and c) a syringe for application of said orally acceptable, detector composition to said tooth.

2. The kit of claim 1 , wherein the binding composition comprises a dentifrice.

3. The kit of claim 2 , wherein the dentifrice is toothpaste.

4. The kit of claim 1 , wherein the binding composition, the detector composition or both the binding composition and the detector composition further comprise a flavoring agent, a coloring agent, a buffering agent, a sensate ingredient, or a combination of two or more thereof.

5. The kit of claim 1 , wherein the second container comprises propyl gallate.

6. The kit of claim 1 , further comprising printed instructions for i) contacting the tooth of a subject with the orally acceptable binding composition; ii) removing unbound Fe(III)-PP; iii) contacting the tooth with the syringe containing the orally acceptable, detector composition; and iv) detecting formation of the reaction product as an indication of the presence or extent of demineralization on the surface of the tooth.

7. A kit of claim 1 , wherein the orally acceptable, detector composition is in the form of a liquid which can be applied by the syringe.

8. The kit of claim 1 , wherein the binding composition is formulated to be applied by means of a syringe.

9. The kit of claim 1 , wherein said binding composition is formulated to be applied by means of a toothbrush.

10. The kit of claim 1 , wherein said syringe comprises a first syringe, and including a second syringe for application of said binding composition to said tooth.

11. The kit of claim 1 , including a toothbrush for application of said binding composition to said tooth.

Assignees

• Harvard College

Inventors

• Nagai Shigemi
• Nagai Masazumi

Classifications

• A61K8/24 Primary

  Phosphorous; Compounds thereof · CPC title

• A61K6/891

  Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61K6/25 Primary

  Compositions for detecting or measuring, e.g. of irregularities on natural or artificial teeth · CPC title

• A61K6/90

  Compositions for taking dental impressions · CPC title

• A61K6/887

  Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title