Method and apparatus for the fail-safe termination of in vivo drug delivery from an implantable drug delivery system
US-2018280617-A1 · Oct 4, 2018 · US
US9388916B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9388916-B2 |
| Application number | US-201113307665-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 30, 2011 |
| Priority date | Nov 30, 2011 |
| Publication date | Jul 12, 2016 |
| Grant date | Jul 12, 2016 |
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A microvalve device is provided that includes a through via located in an island structure supported on a thermally-insulating membrane supported by a frame. The through via is surrounded by a meltable sealing material. A heater element is positioned on the island structure for sealing the material over the through via by heating the sealing material.
Opening claim text (preview).
What is claimed is: 1. A microvalve device comprising: an island structure that includes a throughway located in the island structure supported on a thermally-insulating membrane supported by a frame, the throughway is surrounded by a meltable sealing material on the island structure, the meltable sealing material includes a hollow cylindrical shape that surrounds the throughway having an aspect ratio to ensure upon thermal actuation the meltable sealing material reflows into a toroid due to surface tension; and a heater element that is positioned underneath the island structure for sealing the material over the throughway by heating the sealing material, the sealing material prohibits a wetting interaction with an outer surface of the island structure driving a seal to spread towards the throughway upon melting, wherein inner edges of the toroid meet to thereby plug the throughway. 2. The microvalve device of claim 1 , wherein the thermally-insulating membrane comprises silicon nitride or a multi-layer structure of silicon nitride and silicon oxide. 3. The microvalve device of claim 1 , wherein the island structure comprises silicon, silicon carbide, glass, or metal. 4. The microvalve device of claim 1 , wherein the island structure comprises a diameter between 2 mm and 3 mm. 5. The microvalve device of claim 1 , wherein the frame comprises silicon, silicon carbide, glass, or metal. 6. The microvalve device of claim 5 , wherein the frame comprises an inner diameter between 3 mm and 4 mm. 7. The microvalve device of claim 1 , wherein the meltable sealing material comprises indium, soldering materials, or thermoplastic polymers. 8. The microvalve device of claim 7 , wherein the meltable sealing material comprises an aspect ratio approximately equal to or greater than 1:1. 9. The microvalve device of claim 1 , wherein the heater element comprises a resistive heating element. 10. A method of forming a single-use microvalve structure comprising: forming an island structure that includes a throughway located in the island structure supported on a thermally-insulating membrane supported by a frame, the throughway is surrounded by a meltable sealing material on the island structure, the meltable sealing material includes a hollow cylindrical shape that surrounds the throughway having an aspect ratio to ensure upon thermal actuation the meltable sealing material reflows into a toroid due to surface tension; and positioning a heater element underneath the island structure for sealing the material over the throughway by heating the sealing material, the sealing material prohibits a wetting interaction with an outer surface of the island structure driving a seal to spread towards the throughway upon melting, wherein inner edges of the toroid meet to thereby plug the throughway. 11. The method of claim 10 , wherein the thermally-insulating membrane comprises silicon nitride or a multi-layer structure of silicon nitride and silicon oxide. 12. The method of claim 10 , wherein the island structure comprises silicon, silicon carbide, glass, or metal. 13. The method of claim 12 , wherein the island structure comprises a diameter between 2 mm and 3 mm. 14. The method of claim 10 , wherein the frame comprises silicon, silicon carbide, glass, or metal. 15. The method of claim 14 , wherein the frame comprises an inner diameter between 3 mm and 4 mm. 16. The method of claim 10 , wherein the meltable sealing material comprises indium, soldering materials, or thermoplastic polymers. 17. The method of claim 16 , wherein the meltable sealing material comprises an aspect ratio approximately equal to or greater than 1:1. 18. The method of claim 10 , wherein the heater elements comprises a resistive heating element.
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