Normally closed valve for microfluidic components of a polymeric layer system and method

Patent metadata

Field	Value
Publication number	US-9664304-B2
Application number	US-201414219086-A
Country	US
Kind code	B2
Filing date	Mar 19, 2014
Priority date	Mar 27, 2013
Publication date	May 30, 2017
Grant date	May 30, 2017

Abstract

A normally closed valve for microfluidic components includes a polymer substrate and a polymer membrane film arranged on the polymer substrate. The polymer substrate has a first chamber, a second chamber, and a fluidic barrier element configured to separate the first chamber from the second chamber. The first chamber is fluidically coupled to the second chamber by the polymer membrane film, and, in an initial configuration, a connection of the polymer membrane film to the fluidic barrier element prevents a fluidic communication of the first chamber to the second chamber. The first chamber is at least partially filled with a substance in the initial configuration, and a transfer of the substance from the first chamber into the second chamber takes place by applying a pressure to the substance. The pressure is chosen to be great enough to disconnect the connection of the polymer membrane film to the fluidic barrier element.

First claim

What is claimed is:

1. A normally closed valve for microfluidic components, comprising:
a polymer substrate defining a first chamber and a second chamber and including a fluidic barrier element separating the first chamber from the second chamber; and
a polymer membrane film arranged on the polymer substrate and configured to control a fluid coupling between the first chamber and the second chamber,
wherein, in an initial configuration, a connection of the polymer membrane film to the fluidic barrier element closes the fluid coupling between the first chamber and the second chamber, the connection being formed by a first wax layer that is materially bonded to the polymer membrane film and the fluidic barrier element, and
wherein the first chamber is at least partially filled with a substance in the initial configuration and configured such that applying a pressure to the substance greater than a breaking pressure threshold disconnects the first wax layer from one of the polymer membrane film and the fluidic barrier element so as to open the fluid coupling between the first chamber and the second chamber to transfer the substance from the first chamber into the second chamber.

2. The normally closed valve according to claim 1 , wherein the connection of the first wax layer to the polymer membrane film and the fluidic barrier element is a material-bonded connection produced by one of soldering, welding, and adhesive bonding.

3. The normally closed valve according to claim 2 , wherein the material-bonded connection of the polymer membrane film to the fluidic barrier element is formed with a welded connection of the first wax layer to the polymer membrane film and the fluidic barrier element, the first wax layer having breaking resistance that is overcome at the breaking pressure threshold.

4. The normally closed valve according to claim 1 , wherein in the initial configuration the polymer membrane film includes a first side connected to the fluidic barrier via the first wax layer and a second opposite side, and the polymer membrane film is coated on the second side directly opposite from the fluidic barrier element with a second wax layer of a predetermined thickness.

5. The normally closed valve according to claim 4 , wherein at least one of the first wax layer and the second wax layer is formed from paraffin.

6. The normally closed valve according to claim 1 , wherein the fluidic barrier element is formed as a web and forms a valve seat of the normally closed valve.

7. The normally closed valve according to claim 1 , wherein the connection of the polymer membrane film to the fluidic barrier element is configured such that heat applied to an interface between the polymer membrane film and the fluidic barrier element reduces the breaking pressure threshold at which the connection of the polymer membrane film to the fluidic barrier element disconnects.

8. The normally closed valve according to claim 1 , wherein the valve is configured to close again after an actuation.

9. The normally closed valve according to claim 1 , wherein the polymer membrane film is formed from one of an elastomer, a thermoplastic elastomer, thermoplastics, a heat-sealing film, and composite TPE films with high battier properties.

10. The normally closed valve according to claim 1 , wherein a thickness of the polymer membrane film is between 5 μm and 300 μm.

11. The normally closed valve according to claim 1 , wherein the breaking pressure threshold greater than or equal to 10 kPa and less than or equal to 1000 kPa.

12. A method for operating a normally closed valve, comprising:
preventing, in an initial configuration, a fluidic communication of a first chamber of a polymer substrate with a second chamber of a polymer substrate via a connection of a polymer membrane film arranged on the polymer substrate to a fluidic barrier element of the substrate, which separate the first chamber from the second chamber, the connection being formed by a wax layer that is materially bonded to the polymer membrane film and the fluidic barrier element; and
applying a pressure greater than a breaking pressure threshold to a substance in the first chamber so as to disconnect the wax layer from one of the polymer membrane film and the fluidic barrier element to enable the fluid communication with the second chamber to transfer the substance from the first chamber into the second chamber.

13. The method according to claim 12 , wherein the breaking pressure threshold is greater than or equal to 10 kPa and less than or equal to 1000 kPa.

14. A normally closed valve for microfluidic components, comprising:
a polymer substrate defining a first chamber and a second chamber and including a fluidic barrier element separating the first chamber from the second chamber; and
a polymer membrane film arranged on the polymer substrate and configured to control a fluid coupling between the first chamber and the second chamber,
wherein, in an initial configuration, a connection of the polymer membrane film to the fluidic barrier element closes the fluid coupling between the first chamber and the second chamber,
wherein the first chamber is at least partially filled with a substance in the initial configuration and configured such that applying a pressure to the substance greater than a breaking pressure threshold disconnects the connection of the polymer membrane film to the fluidic barrier element and opens the fluid coupling between the first chamber and the second chamber to transfer the substance from the first chamber into the second chamber, and
wherein, in the initial configuration, the polymer membrane film includes a first side connected to the fluidic barrier element via the connection and a second side opposite the first side, and the polymer membrane film is coated with a wax layer on the second side directly opposite from the connection with the fluidic barrier element; wherein the material-bonded connection of the polymer membrane film to the fluidic barrier element is formed with a second wax layer between the polymer membrane film and the fluidic barrier element.

15. The normally closed valve according to claim 14 , wherein a surface of the second side of the polymer membrane film is coated with the wax layer directly opposite from the connection with the fluidic barrier element.

Assignees

• Bosch Gmbh Robert

Inventors

• Laermer Franz
• Rupp Jochen
• Czurratis Daniel
• Gumbel Tim

Classifications

• B01L2400/0638

  membrane valves, flap valves · CPC title

• B01L3/502738

  characterised by integrated valves (throttle valves in microfluidic sample containers B01L3/502746) · CPC title

• F16K99/003

  Valves for single use only · CPC title

• F16K2099/0084

  Chemistry or biology, e.g. "lab-on-a-chip" technology · CPC title

• B01L2400/0683

  mechanically breaking a wall or membrane within a channel or chamber · CPC title