Method of using CT/MRI dual modality contrast agent

Patent metadata

Field	Value
Publication number	US-9339562-B2
Application number	US-201113070025-A
Country	US
Kind code	B2
Filing date	Mar 23, 2011
Priority date	Sep 28, 2010
Publication date	May 17, 2016
Grant date	May 17, 2016

Abstract

Nanoparticles are used as a contrast agent for magnetic resonance imaging and computed tomography. Each of the nanoparticles includes a metal alloy core and a plurality of hydrophilic molecules covalently bound to the surface of the metal alloy core. Also disclosed is a method for using the contrast agent.

First claim

What is claimed is:

1. A method of imaging a subject comprising:
administering to a subject an effective amount of a contrast agent,
scanning the subject with a magnetic resonance device and an X-ray computed tomography device, and
generating a magnetic resonance image and a computed tomography image of the subject from the scanning,

wherein the contrast agent contains (i) nanoparticles, each of which includes a metal alloy core and a plurality of hydrophilic molecules covalently bound to the metal alloy of the metal alloy core, the metal alloy core having an average diameter of 1-25 nm and composed of a metal alloy containing a first metal and a second metal, in which the first metal has an X-ray absorption coefficient of 6-11 cm 2 /g at 50 kiloelectron volt and the second metal is paramagnetic, and (ii) an aqueous solvent in which the nanoparticles are dispersed, wherein the nanoparticles are prepared by sonicating a mixture of the metal alloy core and the plurality of hydrophilic molecules.

2. The method of claim 1 , wherein the first metal is selected from the group consisting of Pt, Pd, Au, and Ag; and the second metal is selected from the group consisting of Fe, Co, Ni, and Mn.

3. The method of claim 2 , wherein the first metal is Pt and the second metal is Fe.

4. The method of claim 1 , wherein each of the hydrophilic molecules contains a sulfhydryl group.

5. The method of claim 4 , wherein the first metal is selected from the group consisting of Pt, Pd, Au, and Ag; and the second metal is selected from the group consisting of Fe, Co, Ni, and Mn.

6. The method of claim 1 , wherein the first metal is Pt and the second metal is Fe.

7. The method of claim 4 , wherein each of the hydrophilic molecules contains a targeting moiety.

8. The method of claim 7 , wherein the first metal is Pt, the second metal is Fe, and the targeting moiety is an antibody.

9. The method of claim 1 , wherein the metal alloy core has an average diameter of 2-4 nm; the first metal is selected from the group consisting of Pt, Pd, Au, and Ag; and the second metal is selected from the group consisting of Fe, Co, Ni, and Mn.

10. The method of claim 9 , wherein each of the hydrophilic molecules contains a sulfhydryl group.

11. The method of claim 10 , wherein each of the hydrophilic molecules further contains a targeting moiety that is an antibody.

12. The method of claim 11 , wherein the first metal is Pt and the second metal is Fe.

13. The method of claim 1 , wherein the metal alloy core has an average diameter of 5-7 nm; the first metal is selected from the group consisting of Pt, Pd, Au, and Ag; and the second metal is selected from the group consisting of Fe, Co, Ni, and Mn.

14. The method of claim 13 , wherein each of the hydrophilic molecules contains a sulfhydryl group.

15. The method of claim 14 , wherein each of the hydrophilic molecules further contains a targeting moiety that is an antibody.

16. The method of claim 15 , wherein the first metal is Pt and the second metal is Fe.

17. The method of claim 1 , wherein the metal alloy core has an average diameter of 11-15 nm; the first metal is selected from the group consisting of Pt, Pd, Au, and Ag; and the second metal is selected from the group consisting of Fe, Co, Ni, and Mn.

18. The method of claim 17 , wherein each of the hydrophilic molecules contains a sulfhydryl group.

19. The method of claim 18 , wherein each of the hydrophilic molecules further contains a targeting moiety that is an antibody.

20. The method of claim 19 , wherein the first metal is Pt and the second metal is Fe.

Assignees

• Chen Chia-Chun
• Shieh Dar-Bin
• Chou Shang-Wei
• Wu Ping-Ching
• Hsiao Yu Hong
• Yang yu sang
• Univ Nat Taiwan Normal
• Univ Nat Cheng Kung

Inventors

• Chen Chia-Chun
• Shieh Dar-Bin
• Chou Shang-Wei
• Wu Ping-Ching
• Hsiao Yu Hong
• Yang yu sang

Classifications

• B22F1/054

  Nanosized particles · CPC title

• B22F1/0553

  Complex form nanoparticles, e.g. prism, pyramid, octahedron · CPC title

• B22F1/0018

  Operations & Transport · mapped topic

• B82Y15/00

  Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors · CPC title

• C22C1/0491

  Chemistry & Metallurgy · mapped topic