CT contrast medium for detecting thrombus, comprising fibrin-targeted peptide sequence-conjugated glycol chitosan-gold nanoparticles

Patent metadata

Field	Value
Publication number	US-9717807-B2
Application number	US-201314402214-A
Country	US
Kind code	B2
Filing date	May 13, 2013
Priority date	May 23, 2012
Publication date	Aug 1, 2017
Grant date	Aug 1, 2017

Abstract

The present invention relates to a CT contrast agent for detecting a thrombus, comprising fibrin-targeted peptide sequence-conjugated glycol chitosan-gold nanoparticles. The CT contrast agent for detecting a thrombus according to an embodiment of the present invention may allow rapid and repeated acquisition of CT image information related to the size and location of a thrombus in cardio-cerebral vascular thrombosis, and also enables the imaging monitoring of cerebral thrombus.

First claim

The invention claimed is:

1. A CT contrast agent for detecting a thrombus, comprising a glycol chitosan-gold nanoparticle, to which fibrin-targeted peptide sequences represented by Formula 1 are conjugated;

2. A method of thrombus monitoring using CT imaging, comprising:
1) a step of injecting a CT contrast agent for detecting a thrombus, which comprises glycol chitosan-gold nanoparticles to which fibrin-targeted peptide sequences represented by Formula 1 are conjugated, into an animal but not a human, which has thrombosis; and
2) a step of obtaining a CT image using micro CT;

3. The method of claim 2 , wherein the animal is one type or more selected from the group consisting of dogs, mice, cats, monkeys, sheep, goats, cows, horses, and pigs.

4. The method of claim 2 , wherein the thrombosis is one type or more selected from the group consisting of cerebral thrombosis, cardiovascular thrombosis, and peripheral vascular thrombosis.

5. The method of claim 2 , further comprising a step of 3D-reconstruction of the CT image after step 2).

Assignees

• Dongguk Univ Industry-Academic Coop Found
• Snu R&Db Foundation
• Korea Inst Sci & Tech
• Snu R & Db Found

Inventors

• Kim Dong Eog
• Kim Jeong Yeon
• Sun In Cheol
• Park Sung Kyung
• Ahn Cheol Hee
• Kim Kwang Meyung

Classifications

• G06T12/00

  Tomographic reconstruction from projections · CPC title

• G06T11/003

  Physics · mapped topic

• A61K49/04 Primary

  X-ray contrast preparations · CPC title

• A61K49/0428 Primary

  Surface-modified nanoparticles, e.g. immuno-nanoparticles · CPC title

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title