Apparatus for coded aperture X-ray scatter imaging and method therefor

Patent metadata

Field	Value
Publication number	US-9335281-B2
Application number	US-201214350073-A
Country	US
Kind code	B2
Filing date	Oct 4, 2012
Priority date	Oct 7, 2011
Publication date	May 10, 2016
Grant date	May 10, 2016

Abstract

A system and method for producing images of the structure and composition of an object based on measurements of the low-angle x-ray diffraction properties of the object. The imaging system includes a coded aperture that encodes spatial and spectral features onto radiation scattered from image points within the object. The radiation is detected at a two-dimensional array of detectors, whose output is deconvolved and processed to estimate a three-dimensional image having molecular specificity.

First claim

What is claimed is:

1. A system for providing an image of a region of an object, the region including a plurality of object elements, and the region defining a longitudinal axis, the system comprising:
a source of radiation operable for interrogating the object with a first radiation signal having energy within an energy passband that ranges from approximately 30 keV to approximately 69.5 keV;
a coded aperture operable for modulating a second radiation signal received from the object, the second radiation signal being based on the first radiation signal;
a detector comprising a two-dimensional arrangement of pixels, the detector operable for detecting a modulated image based on the modulated second signal; and
a processor operable for computing an estimate of the composition of the region based on the modulated image and a longitudinal forward model of the system.

2. The system of claim 1 wherein the second radiation signal comprises x-ray radiation scattered by at least one of the plurality of object elements.

3. The system of claim 1 wherein the source is operable for providing the first radiation signal such that it is substantially collimated.

4. The system of claim 1 wherein the source is operable for providing the first radiation signal such that it is substantially fan-shaped.

5. The system of claim 1 wherein the source is operable for providing the first radiation signal such that it is substantially cone-shaped.

6. The system of claim 1 wherein the second radiation signal comprises a fluorescent signal from at least one of the plurality of object elements.

7. The system of claim 1 wherein the coded aperture is operable for modulating the second radiation signal with a periodic function.

8. The system of claim 7 wherein the processor is further operable for demodulating the modulated image to determine the position along the longitudinal axis of at least one of the plurality of object elements.

9. The system of claim 1 wherein the coded aperture comprises an arrangement of apertures that modulates the second radiation signal with a scale-dependent code.

10. The system of claim 9 wherein the processor is further operable for demodulating the scale-dependent code to determine the position along the longitudinal axis of at least one of the plurality of object elements.

11. The system of claim 1 wherein the processor is further operable for processing the modulated image to compute a scatter spectrum for each of at least two of the plurality of object elements.

12. The system of claim 1 wherein the processor is further operable for (1) processing the modulated image to estimate a momentum transfer profile for at least one of the plurality of object elements and (2) determining the composition of the at least one of the plurality of object elements.

13. The system of claim 1 , wherein the processor is further operable for computing the estimate based on polar downsampling.

14. The system of claim 1 wherein the coded aperture is radially symmetric about a center point.

15. The system of claim 1 wherein the coded aperture is radially asymmetric about a center point.

16. The system of claim 1 wherein the coded aperture comprises a plurality of apertures that is in an arrangement that collectively defines a periodic code, and wherein the processor is further operable to independently estimate (1) object density and (2) scatter angle versus position along the longitudinal axis for the plurality of object elements based on the periodic code.

17. A method for estimating the composition of a region of an object, the region including a plurality of object elements, and the region defining a longitudinal axis, the method comprising:
interrogating the region with an input signal comprising x-ray radiation having an energy within an energy passband that ranges from approximately 30 keV to approximately 69.5 keV;
providing a first radiation signal by encoding radiance information on a second radiation signal from the plurality of object elements, wherein the second radiation signal is based on the input signal;
receiving a modulated image at a detector comprising a plurality of irradiance pixels, the modulated image being based on the first radiation signal;
providing an output signal from the detector, the output signal being based on the modulated image; and
computing an estimate of (1) the position along the longitudinal axis and (2) the scatter properties of each of the plurality of object elements based on the output signal and a longitudinal forward model of the system.

18. The method of claim 17 wherein the second radiation signal comprises energy of the input signal scattered by object elements in the region.

19. The method of claim 17 further comprising providing the second radiation signal by stimulating fluorescence at each of the plurality of object points.

20. The method of claim 17 wherein the first radiation signal is encoded by modulating the second radiation signal with a coded aperture that is dimensioned and arranged to modulate the second radiation signal with a periodic function.

21. The method of claim 20 further comprising demodulating the modulated image to determine the position along the longitudinal axis of at least one of the plurality of object elements.

22. The method of claim 17 wherein the first radiation signal is encoded by modulating the second radiation signal with a coded aperture having a plurality of apertures, the plurality of apertures being dimensioned and arranged to modulate the second radiation signal with a scale-dependent code.

23. The method of claim 22 further comprising demodulating the scale-dependent code to determine the position along the longitudinal axis of at least one of the plurality of object elements.

24. The method of claim 17 wherein the radiance information is encoded on the second radiation signal by modulating it with a coded aperture that includes a plurality of apertures arranged in an arrangement that is periodic in at least one dimension.

25. The method of claim 17 wherein the radiance information is encoded on the second radiation signal by modulating it with a coded aperture that includes a plurality of apertures are arranged in an arrangement that is radially symmetric about a center point.

26. The method of claim 17 wherein the radiance information is encoded on the second radiation signal by modulating it with a coded aperture that includes a plurality of apertures are arranged in an arrangement that is radially asymmetric about a center point.

27. The method of claim 17 wherein the estimate of the scatter properties of each of the plurality of object elements is computed based on polar downsampling.

28. The method of claim 17 further comprising:
processing the modulated image to estimate a momentum transfer profile for at least one of the plurality of object elements; and
determining the composition of the at least one of the plurality of object elements.

29. The method of claim 17 further comprising:
providing a coded aperture comprising a plurality of apertures that is in an arrangement that collectively defines a periodic code, wherein the radiance information is encoded on the second radiation signal via the coded aperture;
estimating object density for the plurality of object elements based on the periodic code; and
estimating scatter

Assignees

• Univ Duke

Inventors

• Marks Daniel
• Brady David Jones

Classifications

• G01N23/201 Primary

  by measuring small-angle scattering · CPC title

• G21K2207/005

  Methods and devices obtaining contrast from non-absorbing interaction of the radiation with matter, e.g. phase contrast · CPC title

• G01N23/20008

  Constructional details of analysers, e.g. characterised by X-ray source, detector or optical system; Accessories therefor; Preparing specimens therefor (monochromators for X- rays using crystals G21K1/06) · CPC title

• G01N23/207 Primary

  Diffractometry using detectors, e.g. using a probe in a central position and one or more displaceable detectors in circumferential positions · CPC title