Method for manufacturing fluid handling discs with porous mesh plates for use in ultrasonic mesh nebulizers

Patent metadata

Field	Value
Publication number	US-9303330-B2
Application number	US-201313912678-A
Country	US
Kind code	B2
Filing date	Jun 7, 2013
Priority date	Jun 7, 2013
Publication date	Apr 5, 2016
Grant date	Apr 5, 2016

Abstract

The present disclosure relates to methods for manufacturing porous mesh plates for use in ultrasonic mesh nebulizers, and the porous mesh plates manufactured by those methods. Cone-shaped dimples are first drilled in a substrate (e.g. a plate), but do not penetrate the bottom of the substrate. Next, the substrate (e.g. a plate) is subject to an electrochemical process to remove a layer of material from the surface of the substrate. Enough material is removed to allow the dimples to penetrate the substrate, thereby creating holes in the substrate. The size of the holes can be controlled by the conditions of the electrochemical process.

First claim

What is claimed is:

1. A method for making fluid handling discs as used for drug delivery using mesh nebulizers, comprising:
providing a fluid handling disc having a top surface and a bottom surface;
drilling dimples in the top surface of the disc, wherein the dimples do not penetrate the bottom surface of the disc, and wherein each dimple has a diameter greatest at the top surface and converges to a smaller diameter at the lowest point of the dimple;
patterning channels into the disc the channels attaching fluid flow to deliver liquid to be atomized to the dimples and to carry excess fluid from the dimples out of the disc;
etching the disc via electrochemical etching to remove a layer of material from the bottom surface of the disc, wherein removal of a layer of material from the bottom surface of the disc is sufficient to cause the dimples to penetrate the bottom surface of the disc, thereby creating holes in the disc, and wherein the resulting fluid handling discs are suitable for aerosolizing a liquid;
machining the disc via electrochemical machining to remove a layer of material from the bottom surface of the disc; and
wherein the holes are uniform and have a diameter of less than about 4 μm to allow for the generation of finely atomized aerosol to deliver therapeutic agents and wherein the electrochemical machining removes material from the disc at a higher rate than the electrochemical etching.

2. The method of claim 1 , further comprising etching the disc via electrochemical etching to remove a layer of material from the top surface of the disc.

3. The method of claim 1 , wherein the disc has an initial height of between 50 and 250 μm.

4. The method of claim 1 , wherein the disc is made of stainless steel.

5. The method of claim 1 , wherein the electrochemical etching is carried out at constant current.

6. The method of claim 1 , wherein the electrochemical etching is carried out in a solution comprising phosphoric acid, sulfuric acid, and water.

7. The method of claim 1 , wherein the electrochemical etching is carried out in a solution comprising sodium chloride.

8. The method of claim 1 , wherein the electrochemical etching is carried out in a solution comprising sodium nitrate.

9. The method of claim 1 , wherein the electrochemical etching is carried out in a solution comprising sodium chloride and sodium nitrate in a ratio from 1:50 to 50:1.

10. The method of claim 1 , wherein the dimples are drilled with laser drilling.

11. The method of claim 1 , wherein the dimples are drilled with ion/e-beam drilling.

12. The method of claim 1 , wherein the dimples are conical.

13. The method of claim 1 , wherein 0.5 to 10 microns of material is removed via electrochemical etching.

14. A method for making fluid handling discs as used for drug delivery using mesh nebulizers, comprising:
providing a fluid handling disc having a top surface and a bottom surface;
drilling dimples in the top surface of the handling disc, wherein the dimples do not penetrate the bottom surface of the disc, and wherein each dimple has a diameter greatest at the top surface and converges to a smaller diameter at the lowest point of the dimple;
patterning channels into the fluid handling disc, the channels attaching fluid flow to deliver liquid to be atomized to the dimples and to carry excess fluid from the dimples out of the disc; and
machining the disc via electrochemical machining to remove a layer of material of material from the bottom surface of the disc, wherein removal of a layer of material from the bottom surface of the disc is sufficient to cause the dimples to penetrate the bottom surface of the disc, thereby creating holes in the disc, and wherein the resulting fluid handling discs are suitable for aerosolizing a liquid;
etching the disc via electrochemical etching to remove a layer of material from the bottom surface of the disc;
wherein the holes are uniform and have a diameter of less than about 4 μm to allow for the generation of finely atomized aerosol to deliver therapeutic agents and wherein the electrochemical machining removes material from the disc at a higher rate than the electrochemical etching.

15. The method of claim 14 , wherein the step of etching the disc via electrochemical etching removes a layer of material from the top of the disc.

16. The method of claim 14 , wherein the disc has an initial height of between 50 and 250 μm.

17. The method of claim 14 , wherein the disc is made of stainless steel.

18. The method of claim 15 , wherein the electrochemical etching is carried out at constant current.

19. The method of claim 15 , wherein the electrochemical etching is carried out in a solution comprising phosphoric acid, sulfuric acid, and water.

20. The method of claim 15 , wherein the electrochemical etching is carried out in a solution comprising sodium chloride.

21. The method claim 15 , wherein the electrochemical etching is carried out in a solution comprising sodium nitrate.

22. The method of claim 15 , wherein the electrochemical etching is carried out in a solution comprising sodium chloride and sodium nitrate in a ratio 1:50 to 50:1.

23. The method of claim 14 , wherein the dimples are drilled with laser drilling.

24. The method of claim 14 , wherein the dimples are drilled with ion/e-beam drilling.

25. The method of claim 14 , wherein the dimples are conical.

26. The method of claim 15 , wherein 0.5 to 10 microns of material is removed via electrochemical etching.

Assignees

• Gen Electric

Inventors

• Sundararajan Guruprasad
• Baller Marko Klaus
• Addepalli Swarnagowri
• Seshadri Satyanarayanan
• Rakwal Dinesh R
• Dasgupta Subhashish
• Haveri Heikki

Classifications

• B23H9/00

  Machining specially adapted for treating particular metal objects or for obtaining special effects or results on metal objects (heat treatment by cathodic discharge C21D1/38) · CPC title

• B23H3/08

  Working media · CPC title

• B23H3/00

  Electrochemical machining, i.e. removing metal by passing current between an electrode and a workpiece in the presence of an electrolyte · CPC title

• B23H9/14

  Making holes · CPC title

• B05B17/0638

  spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices · CPC title