Preparative separation/purification system

Patent metadata

Field	Value
Publication number	US-9259669-B2
Application number	US-68132310-A
Country	US
Kind code	B2
Filing date	Oct 2, 2007
Priority date	Oct 2, 2007
Publication date	Feb 16, 2016
Grant date	Feb 16, 2016

Abstract

Collection containers ( 17 ) are heated by head conduction from a container rack ( 18 ) with a heater ( 19 ) as the heat source. When an eluting solvent is supplied into a trap column ( 7 ) by a pump ( 5 ), an eluate containing a target compound exiting from the column ( 7 ) flows through a preparative separation passage ( 13 ) and drips from a solution nozzle ( 13 a ), and this solution is separated into fine droplets by a gas stream blowing from a gas ejection nozzle ( 15 a ). When a droplet touches an inner wall of the container ( 17 ), the volatile solvent immediately vaporizes, leaving the target compound precipitated in solid forms on the inner wall. Thus, the process of vaporizing and drying the eluate to collect the target compound is completed within a short period of time. This process can be performed online and hence is suitable for laborsaving.

First claim

The invention claimed is:

1. A preparative separation/purification system for obtaining a target component in solid forms by vaporizing a solvent in a solution containing the target component obtained by a preparative separation process, comprising:
a container rack;
a container for collecting the target component in solid forms, the container being held in the container rack;
a heating means for heating the container;
a solution nozzle and a liquid supply means for supplying the solution so that the solution is dripped or poured into the container; and
a gas ejection nozzle for producing a gas stream so as to break the solution dripped or poured from an end of the solution nozzle into fine droplets and scatter it within the container, where vaporization of the solvent in the solution is accelerated by producing the gas stream by the gas ejection nozzle so that the gas stream separates the solution into droplets and brings these droplets into contact with an inner wall of the container heated by the heating means, to obtain the target component in dry, solid forms, and for further producing a gas stream so that the gas stream is directly brought into contact with a pool of the solution formed by the droplets which flowed down on the inner wall of the container in order that vaporization of the solvent in the pool of the solution is accelerated by agitating the solution by the gas stream produced by the gas ejection nozzle and supplying heat by the heating means, to obtain the target component in dry, solid forms;
wherein an end of the solution nozzle and an end of a gas ejection port of the gas ejection nozzle are located inside the container when the solution is dripped or poured into the container and the fine droplets are scattered within the container, and
the gas injection port is located close to the end of the solution nozzle.

2. The preparative separation/purification system according to claim 1 , which is characterized by further comprising a gas-heating means for heating a gas before the gas is ejected into the container by the gas ejection nozzle.

3. The preparative separation/purification system according to claim 2 , which is characterized by further comprising a solution-heating means for heating the solution before the solution is dripped or poured into the container by the liquid supply means.

4. The preparative separation/purification system according to claim 1 , which is characterized in that the end of the solution passage and a gas ejection port of the gas ejection nozzle constitutes a multi-tube structure with two or more tubes.

5. The preparative separation/purification system according to claim 2 , which is characterized in that the end of the solution passage and a gas ejection port of the gas ejection nozzle constitutes a multi-tube structure with two or more tubes.

6. The preparative separation/purification system according to claim 3 , which is characterized in that the end of the solution passage and a gas ejection port of the gas ejection nozzle constitutes a multi-tube structure with two or more tubes.

Assignees

• Kono Yutaka
• Nishimura Masayuki
• Boughtflower Bob
• Stasica Przemyslaw
• Shimadzu Corp

Inventors

• Kono Yutaka
• Nishimura Masayuki
• Boughtflower Bob
• Stasica Przemyslaw

Classifications

• B01D15/24 Primary

  relating to the treatment of the fractions to be distributed · CPC title

• G01N30/80

  Fraction collectors · CPC title

• B01D15/00 Primary

  Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor · CPC title