Fungal proteases
US-2016333329-A1 · Nov 17, 2016 · US
Protease variants
US9040280B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9040280-B2 |
| Application number | US-201013510076-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 10, 2010 |
| Priority date | Dec 11, 2009 |
| Publication date | May 26, 2015 |
| Grant date | May 26, 2015 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present invention relates to proteases having at least 75% identity to a protease derived from Thermoascus aurantiacus and comprises at least one modification in the amino acid sequence thereof. These protease variants have improved thermostability. The invention also relates to DNA encoding these proteases, methods of their production, as well as the use thereof.
First claim
Opening claim text (preview).
The invention claimed is: 1. An isolated polypeptide comprising an amino acid sequence having at least 95% sequence identity to residues 1-177 of SEQ ID NO: 2 and a substitution at position 142 of SEQ ID NO: 2, wherein the amino acid sequence has the protease specificity of the amino acid sequence of 1-177 of SEQ ID NO: 2 and has, at 80° C.-95° C., improved thermostability compared to the amino acids sequence of SEQ ID NO: 1-177 of SEQ ID NO: 2. 2. The isolated polypeptide of claim 1 , wherein the substitution at position 142 is D142L. 3. The isolated polypeptide of claim 1 , wherein the amino acid sequence has at least 99% identity to residues 1-177 of SEQ ID NO: 2. 4. The isolated polypeptide of claim 3 , wherein the substitution at position 142 is D142L.
Assignees
Inventors
Classifications
substrate containing cellulosic material · CPC title
Ethanol, i.e. non-beverage · CPC title
Metalloendopeptidases (3.4.24) · CPC title
- C12N9/58Primary
derived from fungi · CPC title
Biofuels, e.g. bio-diesel · CPC title
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Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9040280B2 cover?
- The present invention relates to proteases having at least 75% identity to a protease derived from Thermoascus aurantiacus and comprises at least one modification in the amino acid sequence thereof. These protease variants have improved thermostability. The invention also relates to DNA encoding these proteases, methods of their production, as well as the use thereof.
- Who is the assignee on this patent?
- Matsui Tomoko, Noergaard Allan, Poulsen Thomas Agersten, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C12N9/58. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 26 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).