Methods for production of arginine biocarbonate at low pressure

Patent metadata

Field	Value
Publication number	US-9029598-B2
Application number	US-201013515827-A
Country	US
Kind code	B2
Filing date	Dec 14, 2010
Priority date	Dec 18, 2009
Publication date	May 12, 2015
Grant date	May 12, 2015

Abstract

A method of producing arginine bicarbonate is provided including reacting an arginine slurry with a source of carbon dioxide gas under elevated temperature and low pressure to form a solution of at least 50% arginine bicarbonate, and recovering arginine bicarbonate from the solution.

First claim

What is claimed is:

1. A method of producing arginine bicarbonate comprising:
contacting carbon dioxide gas a at a partial pressure of from 6895 Pa (1 psi) to 68947 Pa (10 psi) with a starting slurry containing arginine at a temperature of 60° C. to 80° C. to form a slurry or solution including arginine and bicarbonate anion;
contacting the slurry or solution with carbon dioxide until the slurry or solution forms a solution having a pH below 9; and
recovering arginine bicarbonate from the solution.

2. The method of claim 1 wherein the arginine slurry comprises arginine and a solvent wherein the slurry comprises 10% to 90% by weight arginine in free base or salt form.

3. The method of claim 1 , wherein the solvent is water.

4. The method of claim 1 , wherein the arginine water slurry is in a ratio of 60:40 w/w arginine to water.

5. The method of claim 1 , wherein the arginine is selected from the group consisting of L-arginine, D-arginine, and mixtures thereof.

6. The method of claim 1 , wherein the arginine is selected from the group consisting of arginine hydroxide, arginine hydrochloride, and mixtures thereof.

7. The method of claim 1 , wherein the carbon dioxide gas has a partial pressure from 34474 Pa (5 psi) to about 68947 Pa (10 psi).

8. The method of claim 1 , wherein the arginine slurry and carbon dioxide are maintained under said partial pressure for 90 minutes to 5 hours.

9. The method of claim 1 , wherein the arginine slurry is first heated to a temperature of from 30 C to 80 C for the duration of the reaction, then cooled to a temperature of from 0 C to 40 C after the slurry or solution has a pH below 9.0.

10. The method of claim 1 , wherein the arginine slurry is first heated a temperature of from 60 C to 80 C for the duration of the reaction, then cooled down to a temperature of from 40 C to 25 C.

11. The method of claim 1 , wherein the arginine slurry has a pH of 10 to 14.

12. The method of claim 1 , wherein the arginine bicarbonate solution has a pH of from 7 to 9.

13. The method of claim 1 , wherein the arginine bicarbonate solution has a pH from 8.3 to 8.5.

14. The method of claim 1 , wherein the arginine bicarbonate is recovered from the solution by evaporation or precipitation.

15. The method of claim 1 , wherein sodium bicarbonate is provided to the slurry.

16. The method of claim 1 , wherein the arginine bicarbonate is produced under turbulent conditions.

17. A process for producing arginine bicarbonate comprising:
contacting an arginine water slurry in a ratio of arginine to water of 60:40 with carbon dioxide at a partial pressure of from 6895 Pa (1 psi) to 68947 Pa (10 psi);
heating the arginine slurry to a temperature of from 60 C to 80 C for the duration of the reaction until a slurry or solution containing at least 50% arginine bicarbonate having a pH of less than 9 is formed; and
cooling the resulting slurry or solution to 25 C, to form a solution of arginine bicarbonate having a concentration of arginine bicarbonate of 50% by weight.

Assignees

• Garcia Joaquin Bautista
• Cabanas Robin S
• Josias Wilbens
• Wu Donghui
• Colgate Palmolive Co

Inventors

• Garcia Joaquin Bautista
• Cabanas Robin S
• Josias Wilbens
• Wu Donghui

Classifications

• C07C277/00 Primary

  Preparation of guanidine or its derivatives, i.e. compounds containing the group [IMAGE cpc-sch-C07C-0970.gif], the singly-bound nitrogen atoms not being part of nitro or nitroso groups · CPC title

• C07C279/02

  Guanidine; Salts, complexes or addition compounds thereof · CPC title

• C07C279/14

  being further substituted by carboxyl groups · CPC title