Process for preparing guanidino acetic acid
US-10844009-B2 · Nov 24, 2020 · US
Method for preparing guanidino acetic acid
US11795142B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11795142-B2 |
| Application number | US-202118043572-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 18, 2021 |
| Priority date | Sep 1, 2020 |
| Publication date | Oct 24, 2023 |
| Grant date | Oct 24, 2023 |
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- Title
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Abstract
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A modified method for preparing guanidino acetic acid (GAA) involves reacting cyanamide with an excess molar amount of glycine in an aqueous reaction mixture, in the presence of a base. The method avoids high molar amounts of base or acid for pH control, and maintains the reaction selectivity and product yields.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for preparing guanidino acetic acid (GAA) from cyanamide and glycine, the method comprising: continuously adding the cyanamide and the glycine to a pre-mixed aqueous solution comprising the glycine and a base, wherein a rate of addition of the cyanamide and the glycine is adjusted such that a molar ratio of base to glycine within a reaction mixture is kept constant at 0.1 to 0.4 over an entire reaction period. 2. The method of claim 1 , wherein the cyanamide is reacted with an overall equimolar amount of the glycine, and wherein subsequently, a remaining molar amount of the cyanamide without glycine is continuously added to a glycine containing reaction mixture while maintaining a pH of the reaction mixture below 10 by adding an acid. 3. The method of claim 1 , wherein the cyanamide and the glycine are simultaneously added to the reaction mixture in a form of a mixture comprising both the cyanamide and the glycine.
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Classifications
- C07C279/14Primary
being further substituted by carboxyl groups · CPC title
- C07C277/00Primary
Preparation of guanidine or its derivatives, i.e. compounds containing the group [IMAGE cpc-sch-C07C-0970.gif], the singly-bound nitrogen atoms not being part of nitro or nitroso groups · CPC title
- C07C277/02Primary
of guanidine from cyanamide, calcium cyanamide or dicyandiamides · CPC title
of substituted guanidines · CPC title
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- What does patent US11795142B2 cover?
- A modified method for preparing guanidino acetic acid (GAA) involves reacting cyanamide with an excess molar amount of glycine in an aqueous reaction mixture, in the presence of a base. The method avoids high molar amounts of base or acid for pH control, and maintains the reaction selectivity and product yields.
- Who is the assignee on this patent?
- Evonik Operations Gmbh
- What technology area does this patent fall under?
- Primary CPC classification C07C279/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 24 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).