Antimicrobial and antiviral treatments of materials

Patent metadata

Field	Value
Publication number	US-2023284629-A1
Application number	US-202118247028-A
Country	US
Kind code	A1
Filing date	Sep 28, 2021
Priority date	Sep 28, 2020
Publication date	Sep 14, 2023
Grant date	—

Abstract

Disclosed are methods of forming an antimicrobial and/or antiviral metal coating on a substrate comprising surface groups that bond to a metal alkoxide to form a 3-dimensional metal oxide/alkoxide adhesion layer. The methods include A) soaking or spraying a substrate comprising a 3-dimensional metal oxide/alkoxide layer with a solution of a transition metal salt, and reduction of the transition metal salt to form a continuous network of transition metal within the 3-D layer, or B) soaking or spraying a substrate comprising a 3-dimensional metal oxide/alkoxide layer with a solution of a post-transition metal salt, sintering at high temperature to form a continuous post-transition metal network within the 3-D layer, and electrolyzing to replace post-transition metal with a transition metal.

First claim

1 . A method of forming an antimicrobial and/or antiviral metal coating on a metal substrate, comprising the steps of:
a) contacting an oxidized surface of a metal substrate with a metal alkoxide solution to form a metal alkoxide layer on the metal substrate surface; b) subjecting the metal alkoxide layer to conditions sufficient to form a 3-dimensional metal oxide/alkoxide adhesion layer on the metal substrate surface; c) infiltrating said 3-dimensional metal oxide/alkoxide adhesion layer with a salt solution of one or more transition metals selected from the group consisting of the transition metals of Groups 4-12 within Periods 4 and 5 of the periodic table; and d) reducing said transition metal salt with a reducing agent solution to form a continuous network of transition metal within said 3-dimensional metal oxide/alkoxide adhesion layer and provide a continuously adherent 3-dimensional coating; wherein said oxidized metal substrate is a metal comprising an oxidized surface.

2 . A method of forming an antimicrobial and/or antiviral metal coating on a metal substrate, comprising the steps of:
a) contacting an oxidized surface of a metal substrate with a metal alkoxide solution to form a metal alkoxide layer on the metal substrate surface; b) subjecting the metal alkoxide layer to conditions sufficient to form a 3-dimensional metal oxide/alkoxide adhesion layer on the metal substrate surface; c) infiltrating said 3-dimensional metal oxide/alkoxide adhesion layer with a salt solution of a post-transition metal selected from the group consisting of aluminum, zinc, gallium, cadmium, indium and tin to form a substrate having an infiltrated adhesion layer; d) sintering said substrate having an infiltrated adhesion layer at a temperature of about 150° C. to about 550° C. to deposit the post-transition metal atoms within the 3-dimensional metal oxide/alkoxide adhesion layer thereby forming a sintered substrate; and e) electrolyzing said sintered substrate in the presence of a salt solution of one or more transition metals selected from the group consisting of the transition metals of Groups 4-12 within Periods 4 and 5 of the periodic table, thereby replacing the deposited post-transition metal atoms with transition metal atoms and forming a continuous transition metal network within said 3-dimensional metal oxide/alkoxide adhesion layer to provide a substrate containing a continuously adherent 3-dimensional coating; wherein said oxidized metal substrate is a metal comprising an oxidized surface.

3 . The method of claim 1 , wherein said oxidized surface is a native oxide surface.

4 . A method of forming an antimicrobial and/or antiviral metal coating on a polymer surface, comprising the steps of:
a) contacting a surface of a polymer substrate with a metal alkoxide solution to form a metal alkoxide layer on the polymer substrate surface; b) subjecting the metal alkoxide layer to conditions sufficient to form a 3-dimensional metal oxide/alkoxide adhesion layer on the polymer substrate surface; c) infiltrating said 3-dimensional metal oxide/alkoxide adhesion layer with a salt solution of a transition metal selected from the group consisting of the transition metals of Groups 4-12 within Periods 4 and 5 of the periodic table; and d) reducing said transition metal salt with a reducing agent solution to form a continuous network of transition metal within said 3-dimensional metal oxide/alkoxide adhesion layer and provide a continuously adherent 3-dimensional coating; wherein said polymer comprises surface groups that bond to the metal alkoxide in the metal alkoxide solution to form said metal alkoxide layer.

5 . A method of forming an antimicrobial and/or antiviral metal coating on an emulsion surface, comprising the steps of:
a) coating at least one surface of a substrate with a polymer emulsion film to form an exposed polymer emulsion film; b) contacting the exposed polymer emulsion film with a metal alkoxide solution to form a metal alkoxide layer on the surface of the polymer emulsion film; c) subjecting the metal alkoxide layer to conditions sufficient to form a 3-dimensional metal oxide/alkoxide adhesion layer on the polymer emulsion film surface; d) infiltrating said 3-dimensional metal oxide/alkoxide adhesion layer with a salt solution of a transition metal selected from the group consisting of the transition metals of Groups 4-12 within Periods 4 and 5 of the periodic table; and e) reducing said transition metal salt with a reducing agent solution to form a continuous network of transition metal within said 3-dimensional metal oxide/alkoxide adhesion layer and provide a continuously adherent 3-dimensional coating; wherein said emulsion polymer film comprises surface groups that bond to the metal alkoxide in the metal alkoxide solution to form said metal alkoxide layer.

6 . A method of forming an antimicrobial and/or antiviral metal coating on a textile surface, comprising the steps of:
a) contacting a surface of a textile substrate with a metal alkoxide solution to form a metal alkoxide layer on the textile surface; b) subjecting the metal alkoxide layer to conditions sufficient to form a 3-dimensional metal oxide/alkoxide adhesion layer on the textile substrate surface; c) infiltrating said 3-dimensional metal oxide/alkoxide adhesion layer with a salt solution a transition metal selected from the group consisting of the transition metals of Groups 4-12 within Periods 4 and 5 of the periodic table; and d) reducing said transition metal salt with a reducing agent solution to form a continuous network of transition metal within said 3-dimensional metal oxide/alkoxide adhesion layer and provide a continuously adherent 3-dimensional coating; wherein said textile substrate comprises surface groups that bond to the metal alkoxide in the metal alkoxide solution to form said metal alkoxide layer.

7 . The method of claim 1 , wherein the transition metal is selected from the group consisting of Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zr, Nb, Mo, Ru, Rh, Pd and Ag.

8 . The method of claim 7 , wherein the transition metal is copper.

9 . The method of claim 2 , wherein the post-transition metal is zinc.

10 . The method of claim 9 , wherein the transition metal is copper.

11 . The method of claim 1 , wherein said step of reducing said transition metal salt comprises reducing said transition metal salt with a borohydride reducing agent.

12 . The method of claim 11 , wherein said borohydride reducing agent comprises an aqueous borohydride solution.

13 . The method of claim 1 , wherein said transition metal is copper.

14 . The method of claim 1 , wherein the oxidized metal surface is a native oxide, or a metal surface that has been prepared for treatment by oxidation.

15 . An antimicrobial and/or antiviral metal coating on a metal substrate prepared by the method of claim 1 .

16 . An antimicrobial and/or antiviral metal coating on a substrate prepared by the method of claim 4 .

17 . The method of claim 5 , wherein said polymer emulsion film is a paint coating.

18 . The method of claim 17 , wherein said paint coating is over a month old.

19 . The method of claim 17 , wherein said paint coating is over a year old.

20 - 23 . (canceled)

24 . A kit for forming an antimicrobial and/or antiviral metal coating on a substrate, said kit comprising:
one or more containers of metal alkoxide solution; one or more containers of transition metal salt solution; and optionally, one or

Assignees

• Univ Princeton
• Orthobond Corp

Inventors

• Schwartz Jeffrey
• Caicedo-Carvajal Carlos E
• Lutz Gregorg E
• Yang Siyang

Classifications

• C23C18/1658 Primary

  with two steps starting with metal deposition followed by addition of reducing agent · CPC title

• D06M16/00

  Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic · CPC title

• C23C18/1648

  Porous product · CPC title

• C23C18/1644

  porous substrates · CPC title

• C23C18/1692

  Heat-treatment · CPC title