Series of Skin Whitening (Lightening) Compounds
US-2017275224-A1 · Sep 28, 2017 · US
Compositions of polyhydroxylated benzophenones and methods of treatment of neurodegenerative disorders
US2018290960A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2018290960-A1 |
| Application number | US-201816010030-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jun 15, 2018 |
| Priority date | Dec 17, 2015 |
| Publication date | Oct 11, 2018 |
| Grant date | — |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
The present invention relates to polyhydroxylated benzophenone compounds useful in the treatment of neurodegenerative, neurological, psychiatric, and cognitive diseases, in particular those associated with a deficiency in HDAC1 deacetylase activity.
First claim
Opening claim text (preview).
1 . A compound of formula I: or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, isomer, or tautomer thereof, wherein: R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are each independently H, PO(OR x ) 2 , C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), CO(C 3 -C 8 cycloalkyl), CO(3 to 8-membered heterocyclyl), CO(aryl), CO(heteroaryl), CON(R y ) 2 , COO(C 1 -C 6 alkyl), COO(C 2 -C 6 alkenyl), COO(C 2 -C 6 alkynyl), COO(C 3 -C 8 cycloalkyl), COO(3 to 8-membered heterocyclyl), or COO(aryl), COO(heteroaryl) wherein each PO(OR x ) 2 , C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), CO(C 3 -C 8 cycloalkyl), CO(3 to 8-membered heterocyclyl), CO(aryl), CO(heteroaryl), CON(R y ) 2 , COO(C 1 -C 6 alkyl), COO(C 2 -C 6 alkenyl), COO(C 2 -C 6 alkynyl), COO(C 3 -C 8 cycloalkyl), COO(3 to 8-membered heterocyclyl), COO(aryl) or COO(heteroaryl) is optionally substituted with one or more substituents selected from the group consisting of halogen, OH, NH 2 , CN, C 1 -C 6 alkyl, aryl, heteroaryl and C 1 -C 6 alkoxy; R x is independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), CO(C 3 -C 8 cycloalkyl), CO(3 to 8-membered heterocyclyl), CO(aryl), or CO(heteroaryl) wherein each C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), CO(C 3 -C 8 cycloalkyl), CO(3 to 8-membered heterocyclyl), CO(aryl), or CO(heteroaryl) is optionally substituted with one or more substituents selected from the group consisting of halogen, OH, NH 2 , CN, C 1 -C 6 alkyl, aryl, heteroaryl and C 1 -C 6 alkoxy; R y is independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), CO(C 3 -C 8 cycloalkyl), CO(3 to 8-membered heterocyclyl), CO(aryl), or CO(heteroaryl) wherein each C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), CO(C 3 -C 8 cycloalkyl), CO(3 to 8-membered heterocyclyl), CO(aryl), or CO(heteroaryl) is optionally substituted with one or more substituents selected from the group consisting of halogen, OH, NH 2 , CN, C 1 -C 6 alkyl, aryl, heteroaryl and C 1 -C 6 alkoxy; provided that the compound is not: 2 . The compound of claim 1 having the formula Ia: wherein: R 1 is PO(OR x ) 2 , C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), CO(C 3 -C 8 cycloalkyl), CO(3 to 8-membered heterocyclyl), CO(aryl), CO(heteroaryl), CON(R y ) 2 , COO(C 1 -C 6 alkyl), COO(C 2 -C 6 alkenyl), COO(C 2 -C 6 alkynyl), COO(C 3 -C 8 cycloalkyl), COO(3 to 8-membered heterocyclyl), COO(aryl), or COO(heteroaryl), wherein each PO(OR x ) 2 , C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), CO(C 3 -C 8 cycloalkyl), CO(3 to 8-membered heterocyclyl), CO(aryl), CO(heteroaryl), CON(R y ) 2 , COO(C 1 -C 6 alkyl), COO(C 2 -C 6 alkenyl), COO(C 2 -C 6 alkynyl), COO(C 3 -C 8 cycloalkyl), COO(3 to 8-membered heterocyclyl), COO(aryl) or COO(heteroaryl) is optionally substituted with one or more substituents selected from the group consisting of halogen, OH, NH 2 , CN, C 1 -C 6 alkyl, aryl, heteroaryl and C 1 -C 6 alkoxy; R 2 , R 3 , R 4 , R 5 and R 6 are each independently H, PO(OR x ) 2 , C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), CO(C 3 -C 8 cycloalkyl), CO(3 to 8-membered heterocyclyl), CO(aryl), CO(heteroaryl), CON(R y ) 2 , COO(C 1 -C 6 alkyl), COO(C 2 -C 6 alkenyl), COO(C 2 -C 6 alkynyl), COO(C 3 -C 8 cycloalkyl), COO(3 to 8-membered heterocyclyl), COO(aryl), COO(heteroaryl) wherein each PO(OR x ) 2 , C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), CO(C 3 -C 8 cycloalkyl), CO(3 to 8-membered heterocyclyl), CO(aryl), CO(heteroaryl), CON(R y ) 2 , COO(C 1 -C 6 alkyl), COO(C 2 -C 6 alkenyl), COO(C 2 -C 6 alkynyl), COO(C 3 -C 8 cycloalkyl), COO(3 to 8-membered heterocyclyl), COO(aryl) or COO(heteroaryl) is optionally substituted with one or more substituents selected from the group consisting of halogen, OH, NH 2 , CN, C 1 -C 6 alkyl, aryl, heteroaryl and C 1 -C 6 alkoxy; provided that the compound is not: 3 . The compound of claim 1 having the formula Ib: wherein: R 1 is H, PO(OR x ) 2 , C 2 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), CO(C 3 -C 8 cycloalkyl), CO(3 to 8-membered heterocyclyl), CO(aryl), CO(heteroaryl), CON(R y ) 2 , COO(C 1 -C 6 alkyl), COO(C 2 -C 6 alkenyl), COO(C 2 -C 6 alkynyl), COO(C 3 -C 8 cycloalkyl), COO (3 to 8-membered heterocyclyl), COO(aryl), or COO(heteroaryl), wherein each PO(OR x ) 2 , C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), CO(C 3 -C 8 cycloalkyl), CO(3 to 8-membered heterocyclyl), CO(aryl), CO(heteroaryl), CON(R y ) 2 , COO(C 1 -C 6 alkyl), COO(C 2 -C 6 alkenyl), COO(C 2 -C 6 alkynyl), COO(C 3 -C 8 cycloalkyl), COO(3 to 8-membered heterocyclyl), COO(aryl) or COO(heteroaryl) is optionally substituted with one or more substituents selected from the group consisting of halogen, OH, NH 2 , CN, C 1 -C 6 alkyl, aryl, heteroaryl and C 1 -C 6 alkoxy; R 2 , R 3 , R 4 , R 5 and R 6 are each independently H, PO(OR x ) 2 , C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), CO(C 3 -C 8 cycloalkyl), CO(3 to 8-membered heterocyclyl), CO(aryl), CO(heteroaryl), CON(R y ) 2 , COO(C 1 -C 6 alkyl), COO(C 2 -C 6 alkenyl), COO(C 2 -C 6 alkynyl), COO(C 3 -C 8 cycloalkyl), COO(3 to 8-membered heterocyclyl), COO(aryl), or COO(heteroaryl), wherein each PO(OR x ) 2 , C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, 3 to 8-membered heterocyclyl, aryl, heteroaryl, CO(C 1 -C 6 alkyl), CO(C 2 -C 6 alkenyl), CO(C 2 -C 6 alkynyl), C
Assignees
Inventors
Classifications
- C07C49/83Primary
polycyclic · CPC title
Ketones · CPC title
polycyclic · CPC title
Nose · CPC title
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US2018290960A1 cover?
- The present invention relates to polyhydroxylated benzophenone compounds useful in the treatment of neurodegenerative, neurological, psychiatric, and cognitive diseases, in particular those associated with a deficiency in HDAC1 deacetylase activity.
- Who is the assignee on this patent?
- Massachusetts Inst Technology
- What technology area does this patent fall under?
- Primary CPC classification C07C49/83. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu Oct 11 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).