Anti-obesity and anti-dyslipidemic effects of oil palm phenolics in treating atherosclerosis and cardiovascular disease

Patent metadata

Field	Value
Publication number	US-2018185433-A1
Application number	US-201815898477-A
Country	US
Kind code	A1
Filing date	Feb 17, 2018
Priority date	Jan 7, 2010
Publication date	Jul 5, 2018
Grant date	—

Abstract

A composition comprising extracts containing oil palm phenolics in an amount effective for use in a method of reducing cholesterol biosynthesis and thus preventing obesity. The composition up regulates fatty acid beta oxidation and down regulates cholesterol biosynthesis in livers. The composition is useful for prevention of obesity associated diseases. The composition delays the onset of obesity and attenuates the inflammatory response of atherogenic diet, whereby the composition aids to suppress the inflammatory response thereby ameliorating artherosclerosis. The composition delays weight gain or obesity thereby preventing the effects of dyslipidemia.

First claim

We claim:

1 . A composition comprising extracts containing oil palm phenolics in an amount effective for use in a method of reducing cholesterol biosynthesis and thus preventing obesity.

2 . The composition as claimed in claim 1 wherein the composition up regulates fatty acid beta oxidation and down regulates cholesterol biosynthesis in livers,

3 . The composition as claimed in claim 1 wherein the composition is useful for prevention of obesity associated diseases.

4 . The composition as claimed in claim 1 wherein composition is useful for preventing oxidative stress caused by atherogenic diet and thus reducing the inflammatory effects of an atherogenic diet.

5 . The composition as claimed in claim in 5 wherein the composition delays the onset of obesity and attenuates the inflammatory response of atherogenic diet, whereby the composition aids to suppress the inflammatory response thereby ameliorating artherosclerosis.

6 . The composition as claimed in claim 1 wherein the composition delays weight gain or obesity thereby preventing the effects of dyslipidemia.

7 . The composition as claimed in claim 1 wherein the composition is further useful in suppression of liver fat and visceral fat accumulation by was of up-regulating the fatty acid beta oxidation.

8 . The composition as claimed in claim 1 wherein the composition is further useful in preventing alcohol-induced liver damage.

9 . The composition as claimed in claim 1 wherein the composition is further useful in up-regulating unfolded protein response, thus eliminating the proteins that cannot be re-folded.

10 . The composition as claimed in claim 1 wherein composition is further useful in down-regulating antigen presentation.

11 . The composition as claimed in claim 1 wherein the composition is further useful in reducing damaged proteins caused by artherogenic diet.

12 . The composition as claimed in claim 1 wherein the extracts are ernst is obtained from any part of palm on.

13 . The composition as claimed in claim 1 wherein the extract is obtained from palm oil mill vegetation liquor.

14 . Use of a pharmaceutically acceptable amount of a composition comprising extracts containing oil palm phenolics in the preparation of a medicament for preventing obesity and reducing cholesterol biosynthesis in a patient in need thereof.

15 . The use as claimed in claim 19 , effective for up regulating fatty acid beta oxidation and down regulating cholesterol biosynthesis in livers.

16 . The use as claimed in claim 19 , effective for attenuating the effects of atherogenic diet or for providing anti-dyslipidemic properties.

17 . The use as claimed in claim 19 wherein the medicament is provided in solid dosage, liquid dosage or solution form.

18 . The use as claimed in claim 19 wherein the medicament is provided in a pharmaceutically effective form.

19 . The use as claimed in claim 19 wherein the medicament is provided in nutraceutical nutritional supplementary form.

20 . The use as claimed in claim 19 wherein the medicament is provided in a form suitable for oral administration.

Assignees

• Malaysian Palm Oil Board

Inventors

• Leow Soon Sen
• Sambanthamurthi Ravigadevi
• Tan Yew Ai
• P Manickam Kalyana Sundram
• Wahid Mohd Basri

Classifications

• A61K36/889 Primary

  Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto · CPC title

• A61P3/06

  Antihyperlipidemics · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61K31/05

  Phenols {(cannabinoids A61K31/658)} · CPC title