Acne-removing traditional chinese medicine composition and preparation method thereof

Patent metadata

Field	Value
Publication number	US-2017348372-A1
Application number	US-201615538104-A
Country	US
Kind code	A1
Filing date	Jun 24, 2016
Priority date	Aug 28, 2015
Publication date	Dec 7, 2017
Grant date	—

Abstract

Disclosed are an acne-removing traditional Chinese medicine composition and a preparation method thereof, wherein the traditional Chinese medicine composition is made from Garcinia mangostana L pericarp, thyme and Fructus aurantii through steps of ethanol extraction and macroporous resin, and collecting the part eluted by 60%-80% ethanol. The three medicinal materials of the composition have a synergic anti-inflammation effect.

First claim

1 . An acne-removing Chinese medicine composition which is prepared from the following raw materials by weight parts:

mangosteen pericarp
60 to 80 parts

thyme
10 to 20 parts

fructus aurantii

10 to 20 parts.

2 . A method for preparing an acne-removing Chinese medicine composition, comprising the steps of: mixing 60 to 80 parts by weight of mangosteen pericarp, 10 to 20 parts by weight of thyme and 10 to 20 parts by weight of fructus aurantii ; extracting with ethanol; collecting and purifying the extraction solution.

3 . The preparation method of claim 2 , wherein ethanol extraction is performed by using 8 to 12 folds by weight of 76%-95% ethanol-water solution for heating reflux extraction for 1 h-2.5 h.

4 . The preparation method of claim 2 , wherein the purification specifically comprises the following steps:
a. extraction solution is concentrated after filtration, dissolved in ethanol-water solution and refrigerated overnight; and b. filtration is performed, and the filtrate is adsorbed by macroporous adsorption resin and eluted by elution solution.

5 . The preparation method of claim 4 , wherein in step a the concentration is conducted to a specific gravity of 1.05 to 1.1.

6 . The preparation method of claim 4 , wherein in step a the volume ratio of ethanol in the ethanol-water solution is 70%-80%.

7 . The preparation method of claim 4 , wherein in step a the refrigeration overnight is performed at 0° C. to 4° C. for 12 h-18 h.

8 . The preparation method of claim 4 , wherein in step b the elution is performed by water, 20%-40% ethanol-water solution, 60%-80% ethanol-water solution, successively, and the fragment eluted by 60%-80% ethanol-water solution is collected.

9 . A Chinese medicine composition prepared by the preparation method of claim 2 .

10 . An acne-removing preparation, characterized in that it is prepared from the Chinese medicine composition of claim 1 and acceptable excipients.

Assignees

• Infinitus China Co Ltd

Inventors

• Liu Guangrong
• Deng Wenjuan
• Tang Jian

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61K47/46

  Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts · CPC title

• A61K8/96

  containing materials, or derivatives thereof of undetermined constitution · CPC title