Topical compositions comprising fermented extracts of traditional methods of making and using same

Patent metadata

Field	Value
Publication number	US-9333231-B2
Application number	US-201314043035-A
Country	US
Kind code	B2
Filing date	Oct 1, 2013
Priority date	Mar 11, 2009
Publication date	May 10, 2016
Grant date	May 10, 2016

Abstract

The present invention relates to topical compositions containing fermented extracts of Traditional Chinese Medicinal (TCM) ingredients for improving the appearance and skin condition of the user. The topical compositions of the present invention are tailored for different users of different skin compositions according to TCM principles. The fermented TCM extracts are characterized by reduced odor and/or color in comparison with unfermented TCM extracts and are therefore more suitable for use in cosmetic products.

First claim

The invention claimed is:

1. A topical composition for treating periorbital skin of a subject in need thereof, said composition comprising an effective amount of a blend of fermented extracts of an effective amount of Ligusticum chuanxiong root, Paeonia lactiflora root, Rehmannia glutinosa root, and Zizyphus jujube fruit, wherein said blend of fermented extracts is obtained by:
(i) blending Ligusticum chuanxiong root, Paeonia lactiflora root, Rehmannia glutinosa root, and Zizyphus jujube fruit to provide a blend of plant parts;
(ii) fermenting the blend of plant parts with a microorganism, wherein the microorganism is yeast cells, and culturing nutrients; or
(iii) fermenting the blend of plant parts with microorganisms, wherein said microorganisms are yeast cells, in an aqueous environment in substantial absence of additional nutrients in a low nutrient media to catabolically process the blend of plant parts;
(iv) monitoring the fermentation of (ii) or (iii) for signs of plateauing biological activity;
(v) briefly raising the temperature to rupture the yeast cells to release yeast cell contents, or disrupting the yeast cells by sonication; and
(vi) filtering to remove yeast cell debris and to recover the blend of fermented extracts, wherein the blend of fermented extracts has reduced odor and/or color, wherein the blend of fermented extracts is in the form of a fine powder, and wherein the topical composition further comprises a cosmetically or pharmaceutically acceptable carrier.

Assignees

• Cheng Jing
• Chen Chia-Wen
• Schnittger Steven Francis
• Lu Ming
• Elc Man Llc

Inventors

• Cheng Jing
• Chen Chia-Wen
• Schnittger Steven Francis
• Lu Ming

Classifications

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A61P17/10

  Anti-acne agents · CPC title

• A61K2800/85

  Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine · CPC title

• A61K36/756

  Phellodendron, e.g. corktree · CPC title

• A61K36/23

  Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin · CPC title