Porous material and methods related thereto

Patent metadata

Field	Value
Publication number	US-2017291980-A1
Application number	US-201615096882-A
Country	US
Kind code	A1
Filing date	Apr 12, 2016
Priority date	Apr 12, 2016
Publication date	Oct 12, 2017
Grant date	—

Abstract

Disclosed herein is an aerogel made from a polyhydroxy benzene compound crosslinked with formaldehyde. The aerogel is dry and has a first volume and wherein the aerogel can be exposed to a liquid and be re-dried in a gas while retaining at least 70% of the first volume.

First claim

1 . An aerogel comprising a polyhydroxy benzene compound crosslinked with formaldehyde, wherein the aerogel is dry and has a first volume, wherein the aerogel can be exposed to a liquid and be re-dried in a gas while retaining at least 70% of the first volume.

2 . The aerogel of claim 1 , wherein the aerogel is hydrophilic.

3 . The aerogel of claim 1 , wherein the aerogel is hydrophobic.

4 . The aerogel of claim 1 , wherein the aerogel is a functionalized aerogel.

5 . The aerogel of claim 4 , wherein the functionalized aerogel comprises the aerogel and a chemical linker.

6 . The aerogel of claim 4 , wherein the chemical linker comprises a reactive moiety.

7 . The aerogel of claim 4 , wherein the chemical linker comprises an amine, an amide, a silane, an azide, an alkane, an alkene, an alkyne, or a thiol.

8 . The aerogel of claim 4 , wherein the functionalized aerogel comprises the aerogel, a chemical linker, and a signaling moiety, wherein the chemical linker is bound to both the signaling moiety and the aerogel.

9 . The aerogel of claim 8 , wherein the signaling moiety comprises a detection portion and a target binding portion.

10 . The aerogel of claim 1 , wherein the polyhydroxy benzene compound is resorcinol.

11 . The aerogel of claim 1 , wherein the molar ratio of the polyhydroxy benzene compound to formaldehyde in the aerogel is from about 1:1 to about 1:4.

12 . The aerogel of claim 1 , wherein the aerogel can be exposed to a liquid and be re-dried in air while retaining at least 90% of the first volume.

13 . A method of making the aerogel of claim 1 comprising the steps of:
a) crosslinking a polyhydroxy benzene compound with formaldehyde in the presence of an aluminum catalyst, thereby forming a gel having a first volume; and
b) drying the gel in gas, thereby forming an aerogel having a second volume.

14 . The method of claim 13 , wherein the aluminum catalyst is an aluminum salt catalyst.

15 . The method of claim 14 , wherein the aluminum salt catalyst comprises aluminum acetate.

16 . An aerogel produced by the method of claim 13 .

17 . (canceled)

18 . A method comprising
a) incubating a sample obtained from a subject with the aerogel of claim 9 ; and b) determining the presence or absence of a biomarker for a biological condition in the sample using the signaling moiety of the aerogel, wherein the presence of the biomarker indicates the subject has a biological condition, wherein the absence of the biomarker indicates the subject does not have a biological condition.

19 . A method of detecting comprising the steps of:
a) incubating a sample with the aerogel of claim 8 ; and b) detecting the presence or absence of a biomarker for a biological condition in the sample using the signaling moiety of the aerogel.

20 . A device comprising the aerogel of claim 1 .

Assignees

• Southern Res Inst

Inventors

• CAIN Andrew Wayne
• Parks William Madison
• Boohaker Rebecca J
• Pathak Ashish
• Chakraborty Saibal

Classifications

• B01J13/0091

  Preparation of aerogels, e.g. xerogels · CPC title

• C12Q1/6816

  characterised by the detection means (C12Q1/6804 takes precedence) · CPC title

• C08G8/22 Primary

  Resorcinol · CPC title

• C12Q1/6818

  involving interaction of two or more labels, e.g. resonant energy transfer · CPC title