Mass spectrometer

Patent metadata

Field	Value
Publication number	US-2017287691-A1
Application number	US-201415511332-A
Country	US
Kind code	A1
Filing date	Sep 17, 2014
Priority date	Sep 17, 2014
Publication date	Oct 5, 2017
Grant date	—

Abstract

In a mass spectrometer according to the present invention, when MRM measurements for a plurality of MRM transitions need to be performed within one cycle, a measurement order rearranger determines an analysis sequence by sorting the measurement in ascending order of the absolute value of an optimum application voltage (an application voltage which gives the highest ionization efficiency) to the nozzle of the ESI probe. An analysis controller performs the analysis by controlling the high-voltage power source and other relevant units according to the determined analysis sequence. Since the voltage applied to the nozzle within one cycle has no period in which the voltage is changed in the decreasing direction with the same polarity, the cycle time becomes shorter than in a conventional device.

First claim

1 . A mass spectrometer including: an ion source for ionizing a compound in a sample; a mass separation unit for separating ions originating from a compound according to their mass-to-charge ratios; and a detection unit for detecting ions separated according to their mass-to-charge ratios, the mass spectrometer capable of repeatedly performing a cycle of performing a plurality of selected ion monitoring (SIM) measurements with different target ions or a plurality of multiple reaction monitoring (MRM) measurements with different MRM transitions which are combinations of a precursor ion and a product ion to be subjected to a measurement, and the mass spectrometer further comprising:
a) an information collector for collecting information concerning the target ions of the plurality of SIM measurements or the target MRM transitions of the plurality of MRM measurements performed in one cycle within an arbitrary measurement time range; and b) a measurement order determiner for determining an order in which the SIM measurements for the different ions or the MRM measurements for the different MRM transitions are performed within one cycle, the measurement order determiner configured to organize the measurements for the target ions of the plurality of SIM measurements or the target MRM transitions of the plurality of MRM measurements within one cycle collected by the information collector, into groups with respect to each suitable polarity of an application voltage to the ion source for each of the ions or MRM transitions, and to determine the order of the measurements within one cycle by sorting the measurements by an absolute value of the application voltage within each group of the same polarity.

2 . The mass spectrometer according to claim 1 , wherein the measurement order determiner sorts the measurements in ascending order of the absolute value of the application voltage within the group of the same polarity.

3 . The mass spectrometer according to claim 1 , further comprising a control unit for controlling each relevant unit so as to perform the SIM or MRM measurements according to the order of the measurements determined by the measurement order determiner.

4 . The mass spectrometer according to claim 1 , wherein the information collector further comprises an information specifier for allowing an analysis operator to specify a plurality of SIM measurement target ions or a plurality of MRM transitions to be performed within one cycle.

5 . The mass spectrometer according to claim 1 , wherein the ion source is an ion source which employs an electrospray ionization (ESI) method and includes a nozzle for spraying a sample solution while electrically charging this solution, and the application voltage is a voltage applied to the nozzle.

6 . The mass spectrometer according to claim 2 , further comprising a control unit for controlling each relevant unit so as to perform the SIM or MRM measurements according to the order of the measurements determined by the measurement order determiner.

7 . The mass spectrometer according to claim 2 , wherein the information collector further comprises an information specifier for allowing an analysis operator to specify a plurality of SIM measurement target ions or a plurality of MRM transitions to be performed within one cycle.

8 . The mass spectrometer according to claim 3 , wherein the information collector further comprises an information specifier for allowing an analysis operator to specify a plurality of SIM measurement target ions or a plurality of MRM transitions to be performed within one cycle.

9 . The mass spectrometer according to claim 6 , wherein the information collector further comprises an information specifier for allowing an analysis operator to specify a plurality of SIM measurement target ions or a plurality of MRM transitions to be performed within one cycle.

10 . The mass spectrometer according to claim 2 , wherein the ion source is an ion source which employs an electrospray ionization (ESI) method and includes a nozzle for spraying a sample solution while electrically charging this solution, and the application voltage is a voltage applied to the nozzle.

11 . The mass spectrometer according to claim 3 , wherein the ion source is an ion source which employs an electrospray ionization (ESI) method and includes a nozzle for spraying a sample solution while electrically charging this solution, and the application voltage is a voltage applied to the nozzle.

12 . The mass spectrometer according to claim 4 , wherein the ion source is an ion source which employs an electrospray ionization (ESI) method and includes a nozzle for spraying a sample solution while electrically charging this solution, and the application voltage is a voltage applied to the nozzle.

13 . The mass spectrometer according to claim 6 , wherein the ion source is an ion source which employs an electrospray ionization (ESI) method and includes a nozzle for spraying a sample solution while electrically charging this solution, and the application voltage is a voltage applied to the nozzle.

14 . The mass spectrometer according to claim 7 , wherein the ion source is an ion source which employs an electrospray ionization (ESI) method and includes a nozzle for spraying a sample solution while electrically charging this solution, and the application voltage is a voltage applied to the nozzle.

15 . The mass spectrometer according to claim 8 , wherein the ion source is an ion source which employs an electrospray ionization (ESI) method and includes a nozzle for spraying a sample solution while electrically charging this solution, and the application voltage is a voltage applied to the nozzle.

16 . The mass spectrometer according to claim 9 , wherein the ion source is an ion source which employs an electrospray ionization (ESI) method and includes a nozzle for spraying a sample solution while electrically charging this solution, and the application voltage is a voltage applied to the nozzle.

Assignees

• Shimadzu Corp

Inventors

• Asano Natsuyo

Classifications

• H01J49/42

  Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons · CPC title

• H01J49/167 Primary

  Capillaries and nozzles specially adapted therefor; (electrostatic spraying per se B05B5/00) · CPC title

• H01J49/0031 Primary

  Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence) · CPC title

• H01J49/0095

  Particular arrangements for generating, introducing or analyzing both positive and negative analyte ions (ion/ion reactions H01J49/0072) · CPC title

• H01J49/165

  Electrospray ionisation · CPC title